Detailed information NTG1111751

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: HMPREF9425_RS05530
• Genome accession: NZ_GL831112
• Coordinates: 1125941..1126615 (-)
• Length: 224 a.a.
• NCBI ID: WP_003093839.1
• Uniprot ID: -
• Organism: Streptococcus vestibularis ATCC 49124
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1120941..1131615

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF9425_RS05505 (HMPREF9425_1155)	-	1121146..1122423 (-)	1278	WP_003097398.1	pyrimidine-nucleoside phosphorylase	-
HMPREF9425_RS05510 (HMPREF9425_1156)	-	1122420..1123010 (-)	591	WP_003093879.1	class I SAM-dependent methyltransferase	-
HMPREF9425_RS05515 (HMPREF9425_1157)	coaA	1123225..1124145 (+)	921	WP_037621505.1	type I pantothenate kinase	-
HMPREF9425_RS05520 (HMPREF9425_1158)	rpsT	1124214..1124449 (+)	236	Protein_1124	30S ribosomal protein S20	-
HMPREF9425_RS05525 (HMPREF9425_1159)	ciaH	1124536..1125951 (-)	1416	WP_003097403.1	sensor histidine kinase	Regulator
HMPREF9425_RS05530 (HMPREF9425_1160)	ciaR	1125941..1126615 (-)	675	WP_003093839.1	response regulator transcription factor	Regulator
HMPREF9425_RS05535 (HMPREF9425_1161)	-	1126810..1128480 (-)	1671	WP_003097405.1	formate--tetrahydrofolate ligase	-
HMPREF9425_RS05540 (HMPREF9425_1162)	-	1128675..1129358 (+)	684	WP_003094310.1	phosphopantothenate--cysteine ligase	-
HMPREF9425_RS05545 (HMPREF9425_1163)	coaC	1129351..1129914 (+)	564	WP_003097406.1	phosphopantothenoylcysteine decarboxylase	-
HMPREF9425_RS05550 (HMPREF9425_1164)	-	1129907..1130479 (+)	573	WP_037621508.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25408.04 Da
• Isoelectric Point: 4.2405

>NTDB_id=1111751 HMPREF9425_RS05530 WP_003093839.1 1125941..1126615(-) (ciaR) [Streptococcus vestibularis ATCC 49124]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1111751 HMPREF9425_RS05530 WP_003093839.1 1125941..1126615(-) (ciaR) [Streptococcus vestibularis ATCC 49124]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCAAACTCAGTTTTTGATTTTTTAGATGACTTTGCGGATGT
GATGCAAGTATTTGATGGAGATGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTCTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGAGAGCAAGGAATAACGACTCCTGTTCTTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTCGAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAAGCACTTTTGAAACGTTCTGGTAAATTTGACCAAAATACTCTTTCTTTTGGAGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTATGTAGGCGATAAAGAAGTAGAACTTCTTGGTAAAGAATTTGATTTATTGGTCTAC
TTCCTACAAAATCAAAACGTTATCTTGCCTAAGTCGCAAATTTTTGATCGTCTTTGGGGATTTGATAGTGACACTACTAT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACAGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	88.341	99.554	0.879
ciaR	Streptococcus pneumoniae D39	88.341	99.554	0.879
ciaR	Streptococcus pneumoniae R6	88.341	99.554	0.879
ciaR	Streptococcus pneumoniae TIGR4	88.341	99.554	0.879
ciaR	Streptococcus mutans UA159	87.5	100	0.875
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.333	100	0.375
vicR	Streptococcus mutans UA159	35.146	100	0.375
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362