Detailed information NTG0109793

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: ABXG87_RS04110
• Genome accession: NZ_AP031488
• Coordinates: 912553..913227 (+)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus salivarius strain NBRC 13956
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 907553..918227

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABXG87_RS04090 (Ssa13956_07500)	-	908668..909240 (-)	573	WP_353551988.1	ECF transporter S component	-
ABXG87_RS04095 (Ssa13956_07510)	coaC	909269..909814 (-)	546	WP_084871335.1	phosphopantothenoylcysteine decarboxylase	-
ABXG87_RS04100 (Ssa13956_07520)	-	909807..910490 (-)	684	WP_084871336.1	phosphopantothenate--cysteine ligase	-
ABXG87_RS04105 (Ssa13956_07530)	-	910684..912354 (+)	1671	WP_084871337.1	formate--tetrahydrofolate ligase	-
ABXG87_RS04110 (Ssa13956_07540)	ciaR	912553..913227 (+)	675	WP_049546057.1	response regulator transcription factor	Regulator
ABXG87_RS04115 (Ssa13956_07550)	ciaH	913217..914632 (+)	1416	WP_004182392.1	HAMP domain-containing sensor histidine kinase	Regulator
ABXG87_RS04120 (Ssa13956_07560)	rpsT	914710..914946 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
ABXG87_RS04125 (Ssa13956_07570)	coaA	915016..915936 (-)	921	WP_004182393.1	type I pantothenate kinase	-
ABXG87_RS04130 (Ssa13956_07580)	-	916049..916639 (+)	591	WP_004182394.1	class I SAM-dependent methyltransferase	-
ABXG87_RS04135 (Ssa13956_07590)	-	916636..917913 (+)	1278	WP_004182395.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=109793 ABXG87_RS04110 WP_049546057.1 912553..913227(+) (ciaR) [Streptococcus salivarius strain NBRC 13956]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=109793 ABXG87_RS04110 WP_049546057.1 912553..913227(+) (ciaR) [Streptococcus salivarius strain NBRC 13956]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
TATGCAGGTATTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGACAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGCCACGGCTTTGAACTTGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTCTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362