Detailed information NTG1097436

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACM3H0_RS10525
• Genome accession: NZ_CP180685
• Coordinates: 2016818..2017570 (-)
• Length: 250 a.a.
• NCBI ID: WP_001019932.1
• Uniprot ID: A0A5N0LPK2
• Organism: Streptococcus agalactiae strain M14
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2011818..2022570

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACM3H0_RS10495 (ACM3H0_10495)	-	2011876..2012367 (-)	492	WP_000632643.1	PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB	-
ACM3H0_RS10500 (ACM3H0_10500)	-	2012384..2012809 (-)	426	WP_000823120.1	PTS mannose transporter subunit IIA	-
ACM3H0_RS10505 (ACM3H0_10505)	-	2013056..2014090 (-)	1035	WP_000369172.1	hypothetical protein	-
ACM3H0_RS10510 (ACM3H0_10510)	-	2014319..2015473 (-)	1155	WP_000623419.1	ABC transporter permease subunit	-
ACM3H0_RS10515 (ACM3H0_10515)	-	2015479..2016327 (-)	849	WP_000926588.1	ABC transporter ATP-binding protein	-
ACM3H0_RS10520 (ACM3H0_10520)	-	2016450..2016749 (-)	300	WP_000002567.1	GHKL domain-containing protein	-
ACM3H0_RS10525 (ACM3H0_10525)	comE/blpR	2016818..2017570 (-)	753	WP_001019932.1	response regulator transcription factor	Regulator
ACM3H0_RS10530 (ACM3H0_10530)	-	2017847..2018662 (-)	816	WP_001029868.1	endonuclease/exonuclease/phosphatase family protein	-
ACM3H0_RS10535 (ACM3H0_10535)	-	2018716..2020899 (-)	2184	WP_000795063.1	PTS transporter subunit IIBC	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29726.20 Da
• Isoelectric Point: 6.4980

>NTDB_id=1097436 ACM3H0_RS10525 WP_001019932.1 2016818..2017570(-) (comE/blpR) [Streptococcus agalactiae strain M14]
MNIFILEDDFVQQAHFEKIIKEIRVQYNLHFKTVETFAKPVQLLESIYEIGLHNLFFLDIEIKNDEQMGLEVAKQIRQVD
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEEFSQRIEEVLLYVDGICNKPLVENSFYFKSRYSQVQLPFNDLLY
IETSSRSHRVVLYTEKDRMEFTATLGDILKQEPRLFQCHRSFLVNPLNIFKVDRIDRLVYFQNGTTCLVSRNKVRDIVSI
VDKYQKDRKR

Nucleotide

• Length: 753 bp

>NTDB_id=1097436 ACM3H0_RS10525 WP_001019932.1 2016818..2017570(-) (comE/blpR) [Streptococcus agalactiae strain M14]
GTGAATATTTTTATACTTGAGGATGATTTTGTTCAACAAGCCCATTTTGAAAAAATCATTAAAGAGATTAGAGTACAGTA
CAATCTGCATTTCAAAACAGTAGAAACGTTTGCTAAACCAGTTCAATTATTGGAATCAATTTATGAAATAGGTTTACATA
ATTTATTTTTCTTAGATATTGAAATAAAAAATGATGAGCAGATGGGCTTAGAGGTAGCAAAACAAATTAGACAAGTTGAT
CCATATGCTCAGATTGTTTTTGTTACAACTCATTCAGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGAGTTTAGCCAAAGGATTGAGGAAGTATTGTTGTACGTAGATGGCATTTGCA
ATAAGCCCTTAGTGGAAAATTCATTCTACTTTAAGTCGCGTTACAGCCAGGTACAATTACCTTTTAACGATCTTCTTTAT
ATAGAAACATCCTCAAGATCACATAGAGTTGTCCTTTATACTGAAAAAGATAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTCATCGCTCTTTTTTAGTAAATCCCTTAAATATTTTTAAAGTGGATA
GGATAGATAGATTAGTTTACTTCCAAAATGGAACGACTTGTCTGGTTTCACGCAATAAAGTGAGAGATATAGTATCTATA
GTGGATAAATATCAAAAGGATAGAAAAAGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-238)

3D structure

• AlphaFold DB: A0A5N0LPK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.479	96.8	0.508
comE/comE1	Streptococcus equinus JB1	41.564	97.2	0.404
comE	Streptococcus infantis strain Atu-4	37.052	100	0.372
comE	Streptococcus mitis NCTC 12261	36.653	100	0.368
comE	Streptococcus mitis SK321	36.653	100	0.368
comE	Streptococcus pneumoniae R6	36.694	99.2	0.364
comE	Streptococcus pneumoniae TIGR4	36.694	99.2	0.364
comE	Streptococcus pneumoniae Rx1	36.694	99.2	0.364
comE	Streptococcus pneumoniae D39	36.694	99.2	0.364