Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   ACJWMC_RS11190 Genome accession   NZ_CP177181
Coordinates   2358081..2358269 (-) Length   62 a.a.
NCBI ID   WP_002892439.1    Uniprot ID   J7SHM9
Organism   Streptococcus salivarius strain MRD1919     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2356687..2421268 2358081..2358269 within 0


Gene organization within MGE regions


Location: 2356687..2421268
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMC_RS11185 - 2357173..2357964 (-) 792 WP_002892438.1 hypothetical protein -
  ACJWMC_RS11190 prx 2358081..2358269 (-) 189 WP_002892439.1 hypothetical protein Regulator
  ACJWMC_RS11195 - 2358376..2358534 (-) 159 WP_002892441.1 hypothetical protein -
  ACJWMC_RS11200 - 2358547..2359173 (-) 627 WP_037598719.1 hypothetical protein -
  ACJWMC_RS11205 - 2359194..2359547 (-) 354 WP_002892445.1 hypothetical protein -
  ACJWMC_RS11210 - 2359592..2360143 (-) 552 WP_002892446.1 hypothetical protein -
  ACJWMC_RS11215 - 2360258..2360437 (-) 180 WP_002892449.1 hypothetical protein -
  ACJWMC_RS11220 - 2360440..2360889 (-) 450 WP_224111189.1 GNAT family N-acetyltransferase -
  ACJWMC_RS11225 - 2360919..2361419 (-) 501 WP_002892451.1 hypothetical protein -
  ACJWMC_RS11230 - 2361435..2362082 (-) 648 WP_002892453.1 RadC family protein -
  ACJWMC_RS11235 - 2362101..2362277 (-) 177 WP_002892455.1 hypothetical protein -
  ACJWMC_RS11240 - 2362290..2362598 (-) 309 WP_037598721.1 hypothetical protein -
  ACJWMC_RS11245 - 2362667..2362846 (-) 180 WP_037598723.1 hypothetical protein -
  ACJWMC_RS11250 - 2363025..2363270 (-) 246 WP_037598725.1 hypothetical protein -
  ACJWMC_RS11255 - 2363322..2364308 (-) 987 WP_002892460.1 ERF family protein -
  ACJWMC_RS11260 - 2364364..2365212 (-) 849 WP_037598726.1 PD-(D/E)XK nuclease-like domain-containing protein -
  ACJWMC_RS11265 ssb 2365295..2365723 (-) 429 WP_002892464.1 single-stranded DNA-binding protein -
  ACJWMC_RS11270 - 2365738..2366106 (-) 369 WP_002892465.1 hypothetical protein -
  ACJWMC_RS11275 - 2366123..2366443 (-) 321 WP_037598727.1 hypothetical protein -
  ACJWMC_RS11280 - 2367424..2368716 (-) 1293 WP_002892469.1 hypothetical protein -
  ACJWMC_RS11285 - 2368832..2369140 (-) 309 WP_002892471.1 hypothetical protein -
  ACJWMC_RS11290 - 2369154..2369576 (-) 423 WP_002892473.1 hypothetical protein -
  ACJWMC_RS11295 - 2369653..2369937 (-) 285 WP_002892475.1 hypothetical protein -
  ACJWMC_RS11300 - 2370079..2370738 (-) 660 WP_002892476.1 hypothetical protein -
  ACJWMC_RS11305 - 2370900..2371679 (-) 780 WP_002892477.1 hypothetical protein -
  ACJWMC_RS11310 - 2371698..2372270 (-) 573 WP_002892478.1 hypothetical protein -
  ACJWMC_RS11315 - 2372462..2373418 (-) 957 WP_037598729.1 hypothetical protein -
  ACJWMC_RS11320 - 2374087..2374254 (-) 168 WP_155115618.1 hypothetical protein -
  ACJWMC_RS11325 - 2375293..2378184 (-) 2892 WP_002892482.1 SEC10/PgrA surface exclusion domain-containing protein -
  ACJWMC_RS11330 - 2378473..2379234 (-) 762 WP_002892483.1 macro domain-containing protein -
  ACJWMC_RS11335 - 2379231..2381078 (-) 1848 WP_037598730.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
  ACJWMC_RS11340 - 2381470..2382162 (-) 693 WP_002892487.1 hypothetical protein -
  ACJWMC_RS11345 - 2382156..2382788 (-) 633 WP_002892490.1 hypothetical protein -
  ACJWMC_RS11350 - 2382788..2383585 (-) 798 WP_002892493.1 thioredoxin family protein -
  ACJWMC_RS11355 - 2383726..2384088 (-) 363 WP_037598731.1 hypothetical protein -
  ACJWMC_RS11360 - 2384106..2385014 (-) 909 WP_155115619.1 replication-relaxation family protein -
  ACJWMC_RS11365 - 2385915..2386223 (+) 309 WP_002892500.1 hypothetical protein -
  ACJWMC_RS11370 - 2386264..2389092 (-) 2829 WP_238538620.1 hypothetical protein -
  ACJWMC_RS11375 - 2389314..2389802 (-) 489 WP_002887147.1 hypothetical protein -
  ACJWMC_RS11380 - 2389877..2391208 (-) 1332 WP_050989618.1 hypothetical protein -
  ACJWMC_RS11385 - 2391645..2392478 (-) 834 WP_371748860.1 DNA/RNA non-specific endonuclease -
  ACJWMC_RS11390 - 2392669..2393652 (-) 984 WP_002892509.1 tyrosine-type recombinase/integrase -
  ACJWMC_RS11395 - 2393843..2395306 (-) 1464 WP_002892510.1 replication initiation protein -
  ACJWMC_RS11400 - 2395969..2396493 (-) 525 WP_037598734.1 hypothetical protein -
  ACJWMC_RS11405 - 2396477..2397307 (-) 831 WP_037598735.1 ParA family protein -
  ACJWMC_RS11410 - 2398970..2400298 (+) 1329 WP_002892518.1 DUF3854 domain-containing protein -
  ACJWMC_RS11415 - 2400329..2400931 (+) 603 WP_002892520.1 GTP pyrophosphokinase -
  ACJWMC_RS11420 - 2401069..2402532 (+) 1464 WP_037598738.1 hypothetical protein -
  ACJWMC_RS11425 - 2402546..2403319 (+) 774 WP_037598740.1 ATPase, T2SS/T4P/T4SS family -
  ACJWMC_RS11430 - 2403339..2403845 (+) 507 WP_002892526.1 Cas9 inhibitor AcrIIA9 family protein -
  ACJWMC_RS11435 - 2403904..2405454 (+) 1551 WP_002892528.1 PcfJ domain-containing protein -
  ACJWMC_RS11440 - 2405566..2405913 (+) 348 WP_141760023.1 hypothetical protein -
  ACJWMC_RS11445 - 2405924..2406619 (+) 696 WP_002892532.1 hypothetical protein -
  ACJWMC_RS11450 - 2406677..2412199 (+) 5523 WP_002892534.1 SNF2-related protein -
  ACJWMC_RS11455 - 2412776..2412931 (+) 156 WP_002887181.1 type A2 lanthipeptide -
  ACJWMC_RS11460 salM 2413015..2415849 (+) 2835 WP_032491806.1 salivaricin biosynthesis lanthionine synthetase SalM -
  ACJWMC_RS11465 - 2415827..2417971 (+) 2145 WP_032491807.1 peptidase domain-containing ABC transporter -
  ACJWMC_RS11470 - 2417968..2418705 (+) 738 WP_002892541.1 ABC transporter ATP-binding protein -
  ACJWMC_RS11475 - 2418707..2420614 (+) 1908 WP_002887185.1 ABC transporter permease -

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7131.29 Da        Isoelectric Point: 5.1186

>NTDB_id=1085979 ACJWMC_RS11190 WP_002892439.1 2358081..2358269(-) (prx) [Streptococcus salivarius strain MRD1919]
MMTFDEVMEAINRGFIKGDKISIVRRNGKIHDYVLPGEKVEPGEIVTEEKVEKVLDELKISR

Nucleotide


Download         Length: 189 bp        

>NTDB_id=1085979 ACJWMC_RS11190 WP_002892439.1 2358081..2358269(-) (prx) [Streptococcus salivarius strain MRD1919]
ATGATGACATTTGATGAAGTAATGGAAGCGATAAACAGAGGGTTTATCAAGGGTGATAAAATCAGTATTGTCCGACGAAA
TGGTAAAATCCATGATTATGTCTTACCAGGAGAGAAAGTAGAGCCTGGAGAAATAGTGACAGAGGAAAAAGTGGAGAAAG
TTCTTGATGAGTTGAAAATAAGTAGGTGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7SHM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

62.069

93.548

0.581
  prx Streptococcus pyogenes MGAS8232

60.345

93.548

0.565
  prx Streptococcus pyogenes MGAS315

56.897

93.548

0.532
  prx Streptococcus pyogenes MGAS315

53.448

93.548

0.5
  prx Streptococcus pyogenes MGAS315

56.25

77.419

0.435
  prx Streptococcus pyogenes MGAS315

61.905

67.742

0.419
  prx Streptococcus pyogenes MGAS315

62.5

64.516

0.403

Multiple sequence alignment