Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACJWMC_RS06150 Genome accession   NZ_CP177181
Coordinates   1238208..1238882 (-) Length   224 a.a.
NCBI ID   WP_002891134.1    Uniprot ID   J7TS49
Organism   Streptococcus salivarius strain MRD1919     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1233208..1243882
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMC_RS06125 - 1233514..1234791 (-) 1278 WP_002891129.1 pyrimidine-nucleoside phosphorylase -
  ACJWMC_RS06130 - 1234788..1235378 (-) 591 WP_002891130.1 class I SAM-dependent methyltransferase -
  ACJWMC_RS06135 coaA 1235492..1236412 (+) 921 WP_037597889.1 type I pantothenate kinase -
  ACJWMC_RS06140 rpsT 1236482..1236718 (+) 237 WP_037597891.1 30S ribosomal protein S20 -
  ACJWMC_RS06145 ciaH 1236803..1238218 (-) 1416 WP_002891133.1 sensor histidine kinase Regulator
  ACJWMC_RS06150 ciaR 1238208..1238882 (-) 675 WP_002891134.1 response regulator transcription factor Regulator
  ACJWMC_RS06155 - 1239081..1240751 (-) 1671 WP_002891135.1 formate--tetrahydrofolate ligase -
  ACJWMC_RS06160 - 1240946..1241629 (+) 684 WP_002891136.1 phosphopantothenate--cysteine ligase -
  ACJWMC_RS06165 coaC 1241622..1242167 (+) 546 WP_004182014.1 phosphopantothenoylcysteine decarboxylase -
  ACJWMC_RS06170 - 1242196..1242768 (+) 573 WP_037597893.1 ECF transporter S component -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25362.02 Da        Isoelectric Point: 4.2897

>NTDB_id=1085946 ACJWMC_RS06150 WP_002891134.1 1238208..1238882(-) (ciaR) [Streptococcus salivarius strain MRD1919]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1085946 ACJWMC_RS06150 WP_002891134.1 1238208..1238882(-) (ciaR) [Streptococcus salivarius strain MRD1919]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGACGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGCGAAAAAGGTGTAACGACTCCTGTTCTTATCATGACGGCA
AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGGGCAGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TTAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGATCGTCTTTGGGGATTTGATAGTGATACTACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362

Multiple sequence alignment