Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACJWMC_RS06145 Genome accession   NZ_CP177181
Coordinates   1236803..1238218 (-) Length   471 a.a.
NCBI ID   WP_002891133.1    Uniprot ID   J7TYU9
Organism   Streptococcus salivarius strain MRD1919     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1231803..1243218
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMC_RS06115 - 1232433..1232831 (-) 399 WP_002891126.1 cytidine deaminase -
  ACJWMC_RS06120 deoC 1232818..1233480 (-) 663 WP_002891127.1 deoxyribose-phosphate aldolase -
  ACJWMC_RS06125 - 1233514..1234791 (-) 1278 WP_002891129.1 pyrimidine-nucleoside phosphorylase -
  ACJWMC_RS06130 - 1234788..1235378 (-) 591 WP_002891130.1 class I SAM-dependent methyltransferase -
  ACJWMC_RS06135 coaA 1235492..1236412 (+) 921 WP_037597889.1 type I pantothenate kinase -
  ACJWMC_RS06140 rpsT 1236482..1236718 (+) 237 WP_037597891.1 30S ribosomal protein S20 -
  ACJWMC_RS06145 ciaH 1236803..1238218 (-) 1416 WP_002891133.1 sensor histidine kinase Regulator
  ACJWMC_RS06150 ciaR 1238208..1238882 (-) 675 WP_002891134.1 response regulator transcription factor Regulator
  ACJWMC_RS06155 - 1239081..1240751 (-) 1671 WP_002891135.1 formate--tetrahydrofolate ligase -
  ACJWMC_RS06160 - 1240946..1241629 (+) 684 WP_002891136.1 phosphopantothenate--cysteine ligase -
  ACJWMC_RS06165 coaC 1241622..1242167 (+) 546 WP_004182014.1 phosphopantothenoylcysteine decarboxylase -
  ACJWMC_RS06170 - 1242196..1242768 (+) 573 WP_037597893.1 ECF transporter S component -

Sequence

Protein


Download         Length: 471 a.a.        Molecular weight: 53518.31 Da        Isoelectric Point: 8.7702

>NTDB_id=1085945 ACJWMC_RS06145 WP_002891133.1 1236803..1238218(-) (ciaH) [Streptococcus salivarius strain MRD1919]
MLTKFFNYLFRRMKSEGFKSFIHFFATFSGIFLVMTVMILQILSYGVYSNVDSSLKMAATKTNSYLEMEMLKRELFLTSE
VDQNNTTTIYQAYDTKGSTDETPDSSGSKKESKKKSKMEDAPHDLSVAANTSVLVLDKNGKVLNVVDKFSSLSNLPIDKN
NIDVISKGSAQNYFDQTEKYRLITEKVDNSLYPDAKYLVIAINTTQLEEATERYVKLIVIMMSFFWLLSVAASMYLAKWS
RRPIQESLEKQKAFVENASHELRTPLAVIQNRLEVLFRKPESTILDNSENIASSLDEVRNMRLLTTNLLNLARRDDGIKP
EIETLEPAFFDTVFTNYAMIAEENEKGFTGQNQVSRPIHTDKTLLKQLMTILFDNAIKYTEDDGHVIFTVRTNDRHLYIS
VADNGPGISDSDKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIVLALKGTIVVKDNHPKGTIFEVKITGV

Nucleotide


Download         Length: 1416 bp        

>NTDB_id=1085945 ACJWMC_RS06145 WP_002891133.1 1236803..1238218(-) (ciaH) [Streptococcus salivarius strain MRD1919]
ATGCTGACTAAATTTTTTAATTATCTCTTTAGGAGAATGAAGTCAGAAGGATTTAAGTCTTTTATTCATTTCTTTGCCAC
TTTTTCTGGTATTTTCCTTGTCATGACTGTCATGATTTTGCAGATTCTGAGTTACGGTGTTTATTCCAATGTGGACTCTA
GTCTGAAAATGGCAGCAACTAAGACCAATTCTTATTTAGAAATGGAAATGCTAAAACGGGAACTTTTTCTGACTTCTGAG
GTAGATCAAAATAATACGACAACCATCTACCAAGCCTATGATACTAAAGGGTCGACAGATGAAACACCTGACTCGAGTGG
CTCTAAAAAAGAATCTAAGAAGAAATCAAAGATGGAAGATGCCCCACACGATTTATCTGTTGCGGCGAATACCAGTGTCT
TAGTGCTTGATAAGAATGGAAAAGTCCTCAATGTCGTTGACAAATTTTCTAGCTTATCCAATTTACCAATAGATAAAAAT
AACATTGATGTTATCAGCAAGGGAAGCGCTCAGAATTATTTCGATCAAACCGAAAAGTATCGCCTGATTACTGAAAAAGT
AGATAATAGTCTCTATCCTGATGCTAAGTACCTTGTTATTGCGATTAATACAACTCAATTGGAAGAAGCCACTGAACGTT
ATGTCAAGCTCATTGTCATCATGATGAGTTTCTTCTGGCTCCTATCTGTTGCGGCTAGTATGTATTTGGCCAAGTGGTCA
AGACGTCCTATCCAGGAAAGTCTGGAGAAGCAGAAGGCATTTGTTGAAAATGCCAGTCACGAGTTACGGACACCGCTTGC
TGTGATTCAAAACCGATTAGAAGTTCTCTTCCGCAAGCCTGAGAGCACCATTTTAGATAATTCAGAGAATATTGCTTCAA
GTCTTGATGAAGTACGTAATATGCGTCTGTTGACGACCAATCTCTTGAACTTGGCTCGTCGTGACGATGGTATTAAGCCG
GAAATCGAAACCTTAGAACCTGCTTTCTTTGATACAGTATTTACCAATTATGCTATGATTGCTGAAGAAAATGAGAAAGG
TTTCACGGGTCAAAACCAAGTTAGTCGTCCAATCCATACTGATAAAACGCTATTGAAGCAGCTAATGACCATATTATTTG
ATAATGCTATTAAATATACGGAAGATGATGGACATGTTATCTTTACGGTTCGCACTAATGACCGACATCTTTATATTTCG
GTAGCTGATAATGGTCCTGGGATATCAGATAGTGATAAGAAAAAAATCTTTGATCGCTTTTATCGCGTAGATAAGGCTAG
AACCAGACAAAAAGGTGGGTTTGGACTGGGCTTATCACTAGCGCAACAAATTGTTTTAGCTCTTAAAGGAACAATTGTTG
TCAAGGACAATCATCCGAAGGGGACTATTTTTGAAGTTAAAATCACTGGAGTTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(361-468)

His Kinase A (phospho-acceptor) domain (HisKA)

(252-317)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TYU9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

56.304

97.665

0.55
  ciaH Streptococcus pneumoniae Rx1

50

98.514

0.493
  ciaH Streptococcus pneumoniae D39

50

98.514

0.493
  ciaH Streptococcus pneumoniae R6

50

98.514

0.493
  ciaH Streptococcus pneumoniae TIGR4

50

98.514

0.493

Multiple sequence alignment