Detailed information NTG1085940

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: ACJWMC_RS04870
• Genome accession: NZ_CP177181
• Coordinates: 965977..966684 (+)
• Length: 235 a.a.
• NCBI ID: WP_002890837.1
• Uniprot ID: J7TI38
• Organism: Streptococcus salivarius strain MRD1919
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 960977..971684

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJWMC_RS04835	-	961225..961413 (+)	189	WP_003097027.1	DNA-directed RNA polymerase subunit beta	-
ACJWMC_RS04840	endA	961475..962356 (+)	882	WP_002890833.1	DNA/RNA non-specific endonuclease	Machinery gene
ACJWMC_RS04845	-	962432..963082 (-)	651	WP_002890834.1	amino acid ABC transporter permease	-
ACJWMC_RS04850	-	963094..963792 (-)	699	WP_002886251.1	amino acid ABC transporter permease	-
ACJWMC_RS04855	-	963810..964643 (-)	834	WP_037597730.1	transporter substrate-binding domain-containing protein	-
ACJWMC_RS04860	-	964655..965422 (-)	768	WP_002885036.1	amino acid ABC transporter ATP-binding protein	-
ACJWMC_RS04865	-	965609..965809 (-)	201	Protein_913	amino acid ABC transporter permease	-
ACJWMC_RS04870	vicR	965977..966684 (+)	708	WP_002890837.1	response regulator YycF	Regulator
ACJWMC_RS04875	vicK	966677..968017 (+)	1341	WP_002890839.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACJWMC_RS04880	vicX	968023..968835 (+)	813	WP_037598119.1	MBL fold metallo-hydrolase	Regulator
ACJWMC_RS04885	-	968895..969254 (+)	360	WP_037597735.1	YbaN family protein	-
ACJWMC_RS04890	-	969306..970520 (-)	1215	WP_002890844.1	aminoacyltransferase	-
ACJWMC_RS04895	yidA	970522..971331 (-)	810	WP_002890845.1	sugar-phosphatase	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27100.98 Da
• Isoelectric Point: 4.8387

>NTDB_id=1085940 ACJWMC_RS04870 WP_002890837.1 965977..966684(+) (vicR) [Streptococcus salivarius strain MRD1919]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAEKPDLVILDLMLPELDGLEVAKEIRKTNHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=1085940 ACJWMC_RS04870 WP_002890837.1 965977..966684(+) (vicR) [Streptococcus salivarius strain MRD1919]
ATGAAAAAAATTCTTGTTGTTGATGATGAAAGACCAATTTCGGATATCATCAAGTTTAATCTGACTAAAGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGTCGTGAAGCATTGGAGCAGTTTGAAGCTGAAAAACCAGACTTGGTCATCCTGGACTTGA
TGCTACCTGAACTAGATGGTTTAGAAGTTGCTAAGGAAATTCGAAAGACAAATCATACACCAATTATCATGCTTTCAGCT
AAGGATAGCGAGTTTGATAAGGTTATCGGGCTAGAAATTGGGGCAGATGACTATGTGACGAAACCATTTTCTAATCGTGA
ATTGTTGGCACGTATCAAAGCTCACTTGCGTCGTACAGAGACTATTGAAACAGCAGTAGAAGAAAGCTCTAACTCAGGCA
AGCAGGAGATTTCAATTGGTGAGTTGATTATTGTTCCAGATGCATTTGTTGCTAAAAAACGTGGAAATGAAGTCGAACTC
ACACACCGTGAATTTGAGTTGCTTTTCCATTTGGCAACTCATATGGGACAAGTGATGACACGTGAACATTTGCTTGAAAC
TGTTTGGGGTTATGACTATTTTGGTGATGTTCGTACGGTTGACGTAACCATTCGTCGTCTCCGTGAAAAAATTGAAGACA
CACCTAGTCGTCCTGAATATATTTTGACGCGTCGTGGTGTTGGTTATTATATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: J7TI38

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.455	98.298	0.447
covR	Streptococcus salivarius strain HSISS4	44.872	99.574	0.447
scnR	Streptococcus mutans UA159	38.136	100	0.383