Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ACK2I7_RS08535 Genome accession   NZ_CP176632
Coordinates   1727002..1728192 (+) Length   396 a.a.
NCBI ID   WP_021002247.1    Uniprot ID   A0AAP6EPL7
Organism   Streptococcus anginosus strain SFAD 40     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1722002..1733192
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACK2I7_RS08510 comE 1723812..1724561 (-) 750 WP_021002244.1 competence system response regulator transcription factor ComE Regulator
  ACK2I7_RS08515 comD/comD2 1724561..1725883 (-) 1323 WP_021002245.1 GHKL domain-containing protein Regulator
  ACK2I7_RS08520 - 1725898..1726047 (-) 150 WP_021002246.1 bacteriocin -
  ACK2I7_RS08530 rlmH 1726329..1726808 (-) 480 WP_041784074.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACK2I7_RS08535 htrA 1727002..1728192 (+) 1191 WP_021002247.1 S1C family serine protease Regulator
  ACK2I7_RS08540 spo0J 1728247..1729014 (+) 768 WP_021002248.1 ParB/RepB/Spo0J family partition protein Regulator
  ACK2I7_RS08545 dnaA 1729243..1730586 (+) 1344 WP_021001132.1 chromosomal replication initiator protein DnaA -
  ACK2I7_RS08550 dnaN 1730743..1731879 (+) 1137 WP_003026819.1 DNA polymerase III subunit beta -
  ACK2I7_RS08555 - 1731879..1732076 (+) 198 WP_003026821.1 DUF951 domain-containing protein -
  ACK2I7_RS08560 - 1732100..1732600 (-) 501 WP_003026823.1 YehR family lipoprotein -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41680.65 Da        Isoelectric Point: 9.5698

>NTDB_id=1081740 ACK2I7_RS08535 WP_021002247.1 1727002..1728192(+) (htrA) [Streptococcus anginosus strain SFAD 40]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLETNGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=1081740 ACK2I7_RS08535 WP_021002247.1 1727002..1728192(+) (htrA) [Streptococcus anginosus strain SFAD 40]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCCATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAATAGTGTGTTTGGAAATGACGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGATGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATCAACCCAGGGAACTCTGGAGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAATTAGAAACAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGATAATATAAAAATCACTTTCTATC
GTAATGGAAAAGAGACCACTACCACTATAAAACTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.312

100

0.763
  htrA Streptococcus mitis NCTC 12261

72.796

100

0.73
  htrA Streptococcus pneumoniae Rx1

72.544

100

0.727
  htrA Streptococcus pneumoniae D39

72.544

100

0.727
  htrA Streptococcus pneumoniae R6

72.544

100

0.727
  htrA Streptococcus pneumoniae TIGR4

72.544

100

0.727
  htrA Streptococcus mutans UA159

55.471

99.242

0.551

Multiple sequence alignment