Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACK2I7_RS04280 Genome accession   NZ_CP176632
Coordinates   879070..879744 (-) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain SFAD 40     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 874070..884744
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACK2I7_RS04265 - 875809..877257 (+) 1449 WP_021001736.1 alpha-amylase -
  ACK2I7_RS04270 - 877454..877588 (-) 135 WP_256381214.1 hypothetical protein -
  ACK2I7_RS04275 ciaH 877734..879080 (-) 1347 WP_021001737.1 sensor histidine kinase Regulator
  ACK2I7_RS04280 ciaR 879070..879744 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  ACK2I7_RS04285 - 880017..880469 (-) 453 WP_021001738.1 hypothetical protein -
  ACK2I7_RS04290 - 880794..881537 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  ACK2I7_RS04300 rplS 881779..882126 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  ACK2I7_RS04305 - 882278..883237 (-) 960 WP_021001748.1 ROK family glucokinase -
  ACK2I7_RS04310 - 883457..883621 (+) 165 WP_235044308.1 LysR family transcriptional regulator -
  ACK2I7_RS04315 - 883602..884201 (+) 600 WP_235044309.1 LysR family transcriptional regulator substrate-binding protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=1081719 ACK2I7_RS04280 WP_003024352.1 879070..879744(-) (ciaR) [Streptococcus anginosus strain SFAD 40]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1081719 ACK2I7_RS04280 WP_003024352.1 879070..879744(-) (ciaR) [Streptococcus anginosus strain SFAD 40]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCGGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATCTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment