Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACK2I7_RS04275 Genome accession   NZ_CP176632
Coordinates   877734..879080 (-) Length   448 a.a.
NCBI ID   WP_021001737.1    Uniprot ID   A0AAP6BMN2
Organism   Streptococcus anginosus strain SFAD 40     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 872734..884080
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACK2I7_RS04250 rpsT 873145..873396 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  ACK2I7_RS04255 - 873461..873970 (+) 510 WP_003024360.1 DNA topology modulation protein -
  ACK2I7_RS04260 - 874019..875632 (-) 1614 WP_057489678.1 M20/M25/M40 family metallo-hydrolase -
  ACK2I7_RS04265 - 875809..877257 (+) 1449 WP_021001736.1 alpha-amylase -
  ACK2I7_RS04270 - 877454..877588 (-) 135 WP_256381214.1 hypothetical protein -
  ACK2I7_RS04275 ciaH 877734..879080 (-) 1347 WP_021001737.1 sensor histidine kinase Regulator
  ACK2I7_RS04280 ciaR 879070..879744 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  ACK2I7_RS04285 - 880017..880469 (-) 453 WP_021001738.1 hypothetical protein -
  ACK2I7_RS04290 - 880794..881537 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  ACK2I7_RS04300 rplS 881779..882126 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  ACK2I7_RS04305 - 882278..883237 (-) 960 WP_021001748.1 ROK family glucokinase -
  ACK2I7_RS04310 - 883457..883621 (+) 165 WP_235044308.1 LysR family transcriptional regulator -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 51008.75 Da        Isoelectric Point: 10.1380

>NTDB_id=1081718 ACK2I7_RS04275 WP_021001737.1 877734..879080(-) (ciaH) [Streptococcus anginosus strain SFAD 40]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE
PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1081718 ACK2I7_RS04275 WP_021001737.1 877734..879080(-) (ciaH) [Streptococcus anginosus strain SFAD 40]
ATGCTGAATAAACTTAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG
CCTAAAACCGACACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA
GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGAGTTAGTGTTAAACCTT
TGTTGGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCTGTTTTACAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAACATGAAAATGTTGACGACAAATCTGCTTAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTAATGACGATTCTGTTTGACAATGCTCT
GAAATATACAGATGAAGACGGTGTGATTGAATTGACAATTTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.205

100

0.712
  ciaH Streptococcus pneumoniae D39

71.205

100

0.712
  ciaH Streptococcus pneumoniae R6

71.205

100

0.712
  ciaH Streptococcus pneumoniae TIGR4

71.205

100

0.712
  ciaH Streptococcus mutans UA159

56.009

98.438

0.551

Multiple sequence alignment