Detailed information NTG1080061

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: ACKWPP_RS05180
• Genome accession: NZ_CP176418
• Coordinates: 980827..981498 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain KKAHC02
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 975827..986498

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACKWPP_RS05150 (ACKWPP_05150)	pstC	976010..976927 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
ACKWPP_RS05155 (ACKWPP_05155)	pstA	976917..977804 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
ACKWPP_RS05160 (ACKWPP_05160)	pstB	977829..978632 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
ACKWPP_RS05165 (ACKWPP_05165)	pstB	978644..979402 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
ACKWPP_RS05170 (ACKWPP_05170)	phoU	979431..980087 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
ACKWPP_RS05175 (ACKWPP_05175)	-	980253..980633 (+)	381	WP_024401461.1	hypothetical protein	-
ACKWPP_RS05180 (ACKWPP_05180)	ciaR	980827..981498 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
ACKWPP_RS05185 (ACKWPP_05185)	ciaH	981491..982870 (+)	1380	WP_024401460.1	sensor histidine kinase	Regulator
ACKWPP_RS05190 (ACKWPP_05190)	-	982971..984200 (+)	1230	WP_024401459.1	transglutaminase domain-containing protein	-
ACKWPP_RS05195 (ACKWPP_05195)	rpsT	984464..984712 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
ACKWPP_RS05200 (ACKWPP_05200)	coaA	984771..985691 (-)	921	WP_002935283.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=1080061 ACKWPP_RS05180 WP_014637852.1 980827..981498(+) (ciaR) [Streptococcus suis strain KKAHC02]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=1080061 ACKWPP_RS05180 WP_014637852.1 980827..981498(+) (ciaR) [Streptococcus suis strain KKAHC02]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTTTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTGCCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368