Detailed information    

insolico Bioinformatically predicted

Overview


Name   clpP   Type   Regulator
Locus tag   ACIVIR_RS05475 Genome accession   NZ_CP173225
Coordinates   1051730..1052320 (+) Length   196 a.a.
NCBI ID   WP_000613477.1    Uniprot ID   A0A064BX72
Organism   Streptococcus pneumoniae strain 262     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1050371..1061275 1051730..1052320 within 0


Gene organization within MGE regions


Location: 1050371..1061275
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACIVIR_RS05465 - 1050371..1050838 (+) 468 WP_050221129.1 cytidine/deoxycytidylate deaminase family protein -
  ACIVIR_RS05470 upp 1050927..1051556 (+) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  ACIVIR_RS05475 clpP 1051730..1052320 (+) 591 WP_000613477.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  ACIVIR_RS05480 - 1052399..1052647 (+) 249 WP_000462126.1 YlbG family protein -
  ACIVIR_RS05485 - 1052748..1053908 (+) 1161 WP_000726149.1 ABC transporter substrate-binding protein -
  ACIVIR_RS05490 - 1054176..1055045 (+) 870 WP_000941431.1 branched-chain amino acid ABC transporter permease -
  ACIVIR_RS05495 - 1055049..1056005 (+) 957 WP_000662293.1 branched-chain amino acid ABC transporter permease -
  ACIVIR_RS05500 - 1056005..1056769 (+) 765 WP_001186003.1 ABC transporter ATP-binding protein -
  ACIVIR_RS05505 - 1056769..1057479 (+) 711 WP_000062214.1 ABC transporter ATP-binding protein -
  ACIVIR_RS05510 - 1057787..1058443 (+) 657 WP_000268677.1 CBS domain-containing protein -
  ACIVIR_RS05515 prfB 1058551..1059646 (+) 1096 WP_015511312.1 peptide chain release factor 2 -
  ACIVIR_RS05520 ftsE 1059664..1060356 (+) 693 WP_114880822.1 cell division ATP-binding protein FtsE -
  ACIVIR_RS05525 ftsX 1060349..1061275 (+) 927 WP_000625536.1 permease-like cell division protein FtsX -

Sequence


Protein


Download         Length: 196 a.a.        Molecular weight: 21358.36 Da        Isoelectric Point: 4.4910

>NTDB_id=1070808 ACIVIR_RS05475 WP_000613477.1 1051730..1052320(+) (clpP) [Streptococcus pneumoniae strain 262]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=1070808 ACIVIR_RS05475 WP_000613477.1 1051730..1052320(+) (clpP) [Streptococcus pneumoniae strain 262]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACGAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGGGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains


Predicted by InterproScan.

(11-192)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A064BX72

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

100

100

1

  clpP Streptococcus pneumoniae D39

100

100

1

  clpP Streptococcus pneumoniae R6

100

100

1

  clpP Streptococcus pneumoniae TIGR4

100

100

1

  clpP Streptococcus thermophilus LMG 18311

92.821

99.49

0.923

  clpP Streptococcus thermophilus LMD-9

92.821

99.49

0.923

  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903

  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903

  clpP Streptococcus mutans UA159

85.714

100

0.857

  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847

  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842

  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577

  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571


Multiple sequence alignment