Detailed information NTG0106272

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: AABA14_RS04500
• Genome accession: NZ_AP028607
• Coordinates: 871580..872230 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387331.1
• Uniprot ID: A0A0E7VQD3
• Organism: Streptococcus pneumoniae strain Sep2
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 866580..877230

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA14_RS04470 (TKY123642_08670)	-	867064..867279 (+)	216	WP_001232082.1	YozE family protein	-
AABA14_RS04475 (TKY123642_08680)	-	867365..868333 (+)	969	WP_000658183.1	PhoH family protein	-
AABA14_RS04480 (TKY123642_08690)	-	868526..869026 (+)	501	WP_000566982.1	GNAT family N-acetyltransferase	-
AABA14_RS04485	-	869029..869354 (+)	326	Protein_884	TfoX/Sxy family protein	-
AABA14_RS04490	ald	869655..870766 (-)	1112	Protein_885	alanine dehydrogenase	-
AABA14_RS04495 (TKY123642_08740)	-	870943..871512 (+)	570	WP_000443774.1	GNAT family N-acetyltransferase	-
AABA14_RS04500 (TKY123642_08750)	comEA/celA/cilE	871580..872230 (+)	651	WP_000387331.1	ComEA family DNA-binding protein	Machinery gene
AABA14_RS04505 (TKY123642_08760)	comEC/celB	872214..874454 (+)	2241	WP_000942403.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
AABA14_RS04510 (TKY123642_08770)	-	874633..874821 (+)	189	WP_001809102.1	hypothetical protein	-
AABA14_RS04515 (TKY123642_08780)	-	874853..875440 (+)	588	WP_000933542.1	ABC transporter ATP-binding protein	-
AABA14_RS04520 (TKY123642_08790)	-	875444..876625 (+)	1182	WP_000655958.1	ABC transporter permease	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23203.57 Da
• Isoelectric Point: 5.5171

>NTDB_id=106272 AABA14_RS04500 WP_000387331.1 871580..872230(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain Sep2]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=106272 AABA14_RS04500 WP_000387331.1 871580..872230(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain Sep2]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A0E7VQD3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.907
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361