Detailed information    

insolico Bioinformatically predicted

Overview


Name   clpP   Type   Regulator
Locus tag   AAA996_RS03395 Genome accession   NZ_AP028606
Coordinates   675220..675810 (+) Length   196 a.a.
NCBI ID   WP_000613477.1    Uniprot ID   A0A064BX72
Organism   Streptococcus pneumoniae strain Sep1     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 673861..684766 675220..675810 within 0


Gene organization within MGE regions


Location: 673861..684766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA996_RS03385 (TKY121773_06640) - 673861..674328 (+) 468 WP_000136976.1 cytidine/deoxycytidylate deaminase family protein -
  AAA996_RS03390 (TKY121773_06650) upp 674417..675046 (+) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  AAA996_RS03395 (TKY121773_06660) clpP 675220..675810 (+) 591 WP_000613477.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  AAA996_RS03400 (TKY121773_06670) - 675889..676137 (+) 249 WP_000462126.1 YlbG family protein -
  AAA996_RS03405 (TKY121773_06680) - 676239..677399 (+) 1161 WP_000726149.1 ABC transporter substrate-binding protein -
  AAA996_RS03410 (TKY121773_06690) - 677667..678536 (+) 870 WP_000941421.1 branched-chain amino acid ABC transporter permease -
  AAA996_RS03415 (TKY121773_06700) - 678540..679496 (+) 957 WP_000662292.1 branched-chain amino acid ABC transporter permease -
  AAA996_RS03420 (TKY121773_06710) - 679496..680260 (+) 765 WP_001186008.1 ABC transporter ATP-binding protein -
  AAA996_RS03425 (TKY121773_06720) - 680260..680970 (+) 711 WP_000062219.1 ABC transporter ATP-binding protein -
  AAA996_RS03430 (TKY121773_06730) - 681278..681934 (+) 657 WP_000268655.1 CBS domain-containing protein -
  AAA996_RS03435 (TKY121773_06740) prfB 682042..683137 (+) 1096 WP_010963246.1 peptide chain release factor 2 -
  AAA996_RS03440 (TKY121773_06750) ftsE 683155..683847 (+) 693 WP_000022268.1 cell division ATP-binding protein FtsE -
  AAA996_RS03445 (TKY121773_06760) ftsX 683840..684766 (+) 927 WP_000625536.1 permease-like cell division protein FtsX -

Sequence


Protein


Download         Length: 196 a.a.        Molecular weight: 21358.36 Da        Isoelectric Point: 4.4910

>NTDB_id=106187 AAA996_RS03395 WP_000613477.1 675220..675810(+) (clpP) [Streptococcus pneumoniae strain Sep1]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=106187 AAA996_RS03395 WP_000613477.1 675220..675810(+) (clpP) [Streptococcus pneumoniae strain Sep1]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAACTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGAACAGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains


Predicted by InterproScan.

(11-192)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A064BX72

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

100

100

1

  clpP Streptococcus pneumoniae D39

100

100

1

  clpP Streptococcus pneumoniae R6

100

100

1

  clpP Streptococcus pneumoniae TIGR4

100

100

1

  clpP Streptococcus thermophilus LMG 18311

92.821

99.49

0.923

  clpP Streptococcus thermophilus LMD-9

92.821

99.49

0.923

  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903

  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903

  clpP Streptococcus mutans UA159

85.714

100

0.857

  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847

  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842

  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577

  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571


Multiple sequence alignment