Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   AAA982_RS06265 Genome accession   NZ_AP028601
Coordinates   1232340..1233077 (-) Length   245 a.a.
NCBI ID   WP_277770314.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PF1     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1227340..1238077
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA982_RS06245 (TKY113292_12250) msrB 1228798..1229736 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  AAA982_RS06250 (TKY113292_12260) - 1229765..1229956 (-) 192 WP_001808580.1 hypothetical protein -
  AAA982_RS06255 (TKY113292_12270) thrB 1230032..1230901 (-) 870 WP_000692438.1 homoserine kinase -
  AAA982_RS06260 (TKY113292_12280) - 1230903..1232189 (-) 1287 WP_000216383.1 homoserine dehydrogenase -
  AAA982_RS06265 (TKY113292_12290) mecA 1232340..1233077 (-) 738 WP_277770314.1 adaptor protein MecA Regulator
  AAA982_RS06270 (TKY113292_12300) - 1233277..1234311 (-) 1035 WP_000461502.1 hypothetical protein -
  AAA982_RS06275 (TKY113292_12310) - 1234340..1235773 (-) 1434 WP_055348156.1 O-antigen polysaccharide polymerase Wzy family protein -
  AAA982_RS06280 (TKY113292_12320) - 1235789..1236775 (-) 987 WP_055348157.1 glycosyltransferase family 2 protein -
  AAA982_RS06285 (TKY113292_12330) - 1236777..1237880 (-) 1104 WP_000225894.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28367.16 Da        Isoelectric Point: 4.0162

>NTDB_id=105812 AAA982_RS06265 WP_277770314.1 1232340..1233077(-) (mecA) [Streptococcus pneumoniae strain PF1]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEDQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=105812 AAA982_RS06265 WP_277770314.1 1232340..1233077(-) (mecA) [Streptococcus pneumoniae strain PF1]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGATCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

47.755

100

0.478

Multiple sequence alignment