Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   ACD268_RS06440 Genome accession   NZ_CP168299
Coordinates   1261497..1262147 (-) Length   216 a.a.
NCBI ID   WP_057546897.1    Uniprot ID   A0A4J1WRN7
Organism   Streptococcus pneumoniae strain FC1     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1256497..1267147
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACD268_RS06420 (ACD268_06420) - 1257098..1258282 (-) 1185 WP_000655949.1 ABC transporter permease -
  ACD268_RS06425 (ACD268_06425) - 1258286..1258873 (-) 588 WP_000939886.1 ATP-binding cassette domain-containing protein -
  ACD268_RS06430 (ACD268_06430) - 1258906..1259094 (-) 189 WP_001810030.1 hypothetical protein -
  ACD268_RS06435 (ACD268_06435) comEC/celB 1259273..1261513 (-) 2241 WP_000942408.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  ACD268_RS06440 (ACD268_06440) comEA/celA/cilE 1261497..1262147 (-) 651 WP_057546897.1 ComEA family DNA-binding protein Machinery gene
  ACD268_RS06445 (ACD268_06445) - 1262215..1262784 (-) 570 WP_057546895.1 GNAT family N-acetyltransferase -
  ACD268_RS06450 (ACD268_06450) ald 1262961..1264072 (+) 1112 Protein_1277 alanine dehydrogenase -
  ACD268_RS06455 (ACD268_06455) - 1264373..1264698 (-) 326 Protein_1278 TfoX/Sxy family protein -
  ACD268_RS06460 (ACD268_06460) - 1264701..1265201 (-) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  ACD268_RS06465 (ACD268_06465) - 1265394..1266362 (-) 969 WP_000658183.1 PhoH family protein -
  ACD268_RS06470 (ACD268_06470) - 1266448..1266663 (-) 216 WP_001232081.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23238.66 Da        Isoelectric Point: 5.9204

>NTDB_id=1043717 ACD268_RS06440 WP_057546897.1 1261497..1262147(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain FC1]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVHKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=1043717 ACD268_RS06440 WP_057546897.1 1261497..1262147(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain FC1]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCATAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1WRN7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae D39

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae R6

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

96.759

100

0.968
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.833

100

0.958
  comEA/celA/cilE Streptococcus mitis SK321

89.815

100

0.898
  comEA Lactococcus lactis subsp. cremoris KW2

43.172

100

0.454
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366
  comEA Latilactobacillus sakei subsp. sakei 23K

33.476

100

0.361

Multiple sequence alignment