Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   ACB332_RS04940 Genome accession   NZ_CP167016
Coordinates   979812..980000 (-) Length   62 a.a.
NCBI ID   WP_011054546.1    Uniprot ID   A0A5S4TJS4
Organism   Streptococcus pyogenes strain Isolate 10     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 972224..992339 979812..980000 within 0


Gene organization within MGE regions


Location: 972224..992339
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB332_RS04905 (ACB332_04905) pfkA 972224..973237 (-) 1014 WP_002984444.1 6-phosphofructokinase -
  ACB332_RS04910 (ACB332_04910) - 973317..976427 (-) 3111 WP_031488246.1 DNA polymerase III subunit alpha -
  ACB332_RS04915 (ACB332_04915) - 976612..976983 (+) 372 WP_002989617.1 GntR family transcriptional regulator -
  ACB332_RS04920 (ACB332_04920) - 976983..977681 (+) 699 WP_002984437.1 ABC transporter ATP-binding protein -
  ACB332_RS04925 (ACB332_04925) - 977691..978476 (+) 786 WP_002984433.1 hypothetical protein -
  ACB332_RS04930 (ACB332_04930) - 978607..979221 (-) 615 WP_129322707.1 TVP38/TMEM64 family protein -
  ACB332_RS04940 (ACB332_04940) prx 979812..980000 (-) 189 WP_011054546.1 hypothetical protein Regulator
  ACB332_RS04945 (ACB332_04945) spel 980115..980903 (-) 789 WP_021340779.1 streptococcal pyrogenic exotoxin SpeL -
  ACB332_RS04950 (ACB332_04950) spem 981185..981865 (-) 681 WP_129322708.1 streptococcal pyrogenic exotoxin SpeM -
  ACB332_RS04955 (ACB332_04955) - 981834..982358 (-) 525 WP_129322709.1 Panacea domain-containing protein -
  ACB332_RS04960 (ACB332_04960) - 982497..983705 (-) 1209 WP_012560948.1 glucosaminidase domain-containing protein -
  ACB332_RS04965 (ACB332_04965) - 983821..985188 (-) 1368 WP_371400051.1 terminase large subunit domain-containing protein -
  ACB332_RS04970 (ACB332_04970) - 985203..985670 (-) 468 WP_002985371.1 phage terminase small subunit P27 family -
  ACB332_RS04975 (ACB332_04975) - 985839..986180 (-) 342 WP_029714359.1 HNH endonuclease -
  ACB332_RS04980 (ACB332_04980) - 986416..986601 (+) 186 WP_001132273.1 type II toxin-antitoxin system HicA family toxin -
  ACB332_RS04985 (ACB332_04985) - 986653..987030 (+) 378 WP_002987543.1 type II toxin-antitoxin system HicB family antitoxin -
  ACB332_RS04990 (ACB332_04990) - 987325..987558 (+) 234 WP_002995461.1 hypothetical protein -
  ACB332_RS04995 (ACB332_04995) - 987648..988562 (-) 915 WP_011284864.1 hypothetical protein -
  ACB332_RS05000 (ACB332_05000) - 989334..989774 (-) 441 WP_011017866.1 ArpU family phage packaging/lysis transcriptional regulator -
  ACB332_RS05005 (ACB332_05005) - 990047..990682 (-) 636 WP_021340848.1 N-6 DNA methylase -
  ACB332_RS05010 (ACB332_05010) - 990784..991356 (+) 573 Protein_939 site-specific integrase -
  ACB332_RS05015 (ACB332_05015) - 991719..992339 (+) 621 WP_002989605.1 DUF3862 domain-containing protein -

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7226.17 Da        Isoelectric Point: 3.9947

>NTDB_id=1037645 ACB332_RS04940 WP_011054546.1 979812..980000(-) (prx) [Streptococcus pyogenes strain Isolate 10]
MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPHEEARNGEVVTEEKVEEVMVELDYIK

Nucleotide


Download         Length: 189 bp        

>NTDB_id=1037645 ACB332_RS04940 WP_011054546.1 979812..980000(-) (prx) [Streptococcus pyogenes strain Isolate 10]
ATGCTAACATACGACGAATTTAAGCAAGCTATTGATGACGGATATATCGTAGGAGACACAGTTATGATCGTGCGTAAAAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAGGAAGCGAGAAATGGAGAAGTTGTGACAGAGGAGAAGGTGGAAGAAG
TGATGGTGGAATTAGACTATATCAAATGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TJS4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

100

100

1
  prx Streptococcus pyogenes MGAS315

84.746

95.161

0.806
  prx Streptococcus pyogenes MGAS8232

84.483

93.548

0.79
  prx Streptococcus pyogenes MGAS315

82.759

93.548

0.774
  prx Streptococcus pyogenes MGAS315

77.966

95.161

0.742
  prx Streptococcus pyogenes MGAS315

87.805

66.129

0.581
  prx Streptococcus pyogenes MGAS315

76.19

67.742

0.516

Multiple sequence alignment