Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   ACB355_RS06730 Genome accession   NZ_CP167011
Coordinates   1336096..1336278 (-) Length   60 a.a.
NCBI ID   WP_011018104.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 18     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1336096..1376360 1336096..1336278 within 0


Gene organization within MGE regions


Location: 1336096..1376360
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB355_RS06730 (ACB355_06730) prx 1336096..1336278 (-) 183 WP_011018104.1 hypothetical protein Regulator
  ACB355_RS06735 (ACB355_06735) mf2 1336551..1337309 (+) 759 WP_011184727.1 DNase Mf2 -
  ACB355_RS06740 (ACB355_06740) speC 1337420..1338127 (+) 708 WP_002985327.1 streptococcal pyrogenic exotoxin SpeC -
  ACB355_RS06745 (ACB355_06745) - 1338739..1339948 (-) 1210 Protein_1285 glucosaminidase domain-containing protein -
  ACB355_RS06750 (ACB355_06750) - 1340060..1340515 (-) 456 WP_002988455.1 phage holin family protein -
  ACB355_RS06755 (ACB355_06755) - 1340531..1341157 (-) 627 WP_115224617.1 hypothetical protein -
  ACB355_RS06760 (ACB355_06760) - 1341160..1341588 (-) 429 WP_115224618.1 DUF1617 family protein -
  ACB355_RS06765 (ACB355_06765) - 1341600..1343486 (-) 1887 WP_115224619.1 gp58-like family protein -
  ACB355_RS06770 (ACB355_06770) hylP 1343499..1344521 (-) 1023 WP_020837648.1 hyaluronidase HylP -
  ACB355_RS06775 (ACB355_06775) - 1344518..1346662 (-) 2145 WP_115224620.1 phage tail spike protein -
  ACB355_RS06780 (ACB355_06780) - 1346659..1347375 (-) 717 WP_115224621.1 distal tail protein Dit -
  ACB355_RS06785 (ACB355_06785) - 1347372..1350632 (-) 3261 WP_371394834.1 tape measure protein -
  ACB355_RS06790 (ACB355_06790) - 1350622..1351203 (-) 582 WP_010922087.1 bacteriophage Gp15 family protein -
  ACB355_RS06795 (ACB355_06795) - 1351207..1351641 (-) 435 WP_010922086.1 hypothetical protein -
  ACB355_RS06800 (ACB355_06800) - 1351680..1352165 (-) 486 WP_011054741.1 phage tail tube protein -
  ACB355_RS06805 (ACB355_06805) - 1352165..1352563 (-) 399 WP_010922084.1 minor capsid protein -
  ACB355_RS06810 (ACB355_06810) - 1352560..1352916 (-) 357 WP_010922083.1 minor capsid protein -
  ACB355_RS06815 (ACB355_06815) - 1352916..1353248 (-) 333 WP_010922082.1 minor capsid protein -
  ACB355_RS06820 (ACB355_06820) - 1353238..1353654 (-) 417 WP_010922081.1 hypothetical protein -
  ACB355_RS06825 (ACB355_06825) - 1353708..1354526 (-) 819 WP_010922080.1 N4-gp56 family major capsid protein -
  ACB355_RS06830 (ACB355_06830) - 1354530..1355144 (-) 615 WP_115224623.1 hypothetical protein -
  ACB355_RS06835 (ACB355_06835) - 1355270..1355536 (-) 267 WP_010922078.1 hypothetical protein -
  ACB355_RS06840 (ACB355_06840) - 1355623..1355850 (-) 228 WP_010922077.1 hypothetical protein -
  ACB355_RS06845 (ACB355_06845) - 1355850..1357343 (-) 1494 WP_010922076.1 phage minor capsid protein -
  ACB355_RS06850 (ACB355_06850) - 1357348..1358850 (-) 1503 WP_010922075.1 phage portal protein -
  ACB355_RS06855 (ACB355_06855) - 1358864..1360155 (-) 1292 Protein_1307 PBSX family phage terminase large subunit -
  ACB355_RS06860 (ACB355_06860) - 1360158..1360634 (-) 477 WP_010922073.1 hypothetical protein -
  ACB355_RS06865 (ACB355_06865) - 1360977..1362143 (-) 1167 WP_115224624.1 DNA modification methylase -
  ACB355_RS06870 (ACB355_06870) - 1362477..1362914 (-) 438 WP_003052405.1 DUF1492 domain-containing protein -
  ACB355_RS06875 (ACB355_06875) - 1363116..1363337 (+) 222 WP_032467171.1 hypothetical protein -
  ACB355_RS06880 (ACB355_06880) - 1363370..1363663 (-) 294 WP_011888761.1 hypothetical protein -
  ACB355_RS06885 (ACB355_06885) - 1363754..1364518 (-) 765 WP_021299463.1 site-specific DNA-methyltransferase -
  ACB355_RS06890 (ACB355_06890) - 1364508..1364777 (-) 270 WP_115224625.1 hypothetical protein -
  ACB355_RS06895 (ACB355_06895) - 1364782..1364967 (-) 186 WP_011017985.1 hypothetical protein -
  ACB355_RS06900 (ACB355_06900) - 1364954..1365466 (-) 513 WP_115224626.1 hypothetical protein -
  ACB355_RS06905 (ACB355_06905) - 1365463..1365804 (-) 342 WP_161737273.1 hypothetical protein -
  ACB355_RS06910 (ACB355_06910) - 1365885..1366052 (-) 168 WP_011285624.1 hypothetical protein -
  ACB355_RS06915 (ACB355_06915) - 1366062..1366859 (-) 798 WP_115224628.1 PD-(D/E)XK nuclease-like domain-containing protein -
  ACB355_RS06920 (ACB355_06920) - 1366856..1367821 (-) 966 WP_115224629.1 recombinase RecT -
  ACB355_RS06925 (ACB355_06925) - 1367824..1368153 (-) 330 WP_002988359.1 hypothetical protein -
  ACB355_RS06930 (ACB355_06930) - 1368175..1368429 (-) 255 WP_063629029.1 hypothetical protein -
  ACB355_RS06935 (ACB355_06935) - 1368416..1368763 (-) 348 WP_012560971.1 hypothetical protein -
  ACB355_RS06940 (ACB355_06940) - 1368904..1369686 (-) 783 WP_111705650.1 ATP-binding protein -
  ACB355_RS06945 (ACB355_06945) - 1369673..1370434 (-) 762 WP_014635613.1 DnaD domain protein -
  ACB355_RS06950 (ACB355_06950) - 1370528..1370665 (-) 138 WP_011017881.1 hypothetical protein -
  ACB355_RS06955 (ACB355_06955) - 1370696..1370947 (-) 252 WP_011888682.1 AlpA family transcriptional regulator -
  ACB355_RS06960 (ACB355_06960) - 1371018..1371203 (-) 186 WP_011054585.1 helix-turn-helix transcriptional regulator -
  ACB355_RS06965 (ACB355_06965) - 1371370..1371609 (+) 240 WP_115224630.1 hypothetical protein -
  ACB355_RS06970 (ACB355_06970) - 1371707..1372426 (-) 720 WP_011888681.1 phage antirepressor KilAC domain-containing protein -
  ACB355_RS06975 (ACB355_06975) - 1372454..1372666 (-) 213 WP_014635614.1 DNA-binding protein -
  ACB355_RS06980 (ACB355_06980) - 1372864..1373205 (+) 342 WP_011888679.1 helix-turn-helix transcriptional regulator -
  ACB355_RS06985 (ACB355_06985) - 1373189..1373575 (+) 387 WP_023605207.1 ImmA/IrrE family metallo-endopeptidase -
  ACB355_RS06990 (ACB355_06990) - 1373590..1375011 (+) 1422 WP_014635616.1 DUF4041 domain-containing protein -
  ACB355_RS06995 (ACB355_06995) - 1375194..1376360 (+) 1167 WP_011018152.1 site-specific integrase -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6935.81 Da        Isoelectric Point: 3.9417

>NTDB_id=1037433 ACB355_RS06730 WP_011018104.1 1336096..1336278(-) (prx) [Streptococcus pyogenes strain Isolate 18]
MLTYDEFKQAIDNGYITADTVMIVRKNGQIFDYVLPHEEARNGEVVTEEVVEEVMVELDK

Nucleotide


Download         Length: 183 bp        

>NTDB_id=1037433 ACB355_RS06730 WP_011018104.1 1336096..1336278(-) (prx) [Streptococcus pyogenes strain Isolate 18]
ATGCTAACATACGACGAATTTAAGCAAGCGATTGACAATGGATATATCACAGCAGACACAGTTATGATCGTGCGTAAAAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAAGAAGCGAGAAATGGAGAAGTTGTGACCGAGGAGGTAGTGGAAGAAG
TGATGGTGGAATTAGACAAATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

83.333

100

0.833
  prx Streptococcus pyogenes MGAS315

83.333

100

0.833
  prx Streptococcus pyogenes MGAS315

81.667

100

0.817
  prx Streptococcus pyogenes MGAS315

81.667

100

0.817
  prx Streptococcus pyogenes MGAS8232

80

100

0.8
  prx Streptococcus pyogenes MGAS315

76.667

100

0.767
  prx Streptococcus pyogenes MGAS315

93.023

71.667

0.667

Multiple sequence alignment