Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   ACB333_RS05850 Genome accession   NZ_CP167010
Coordinates   1164190..1164372 (-) Length   60 a.a.
NCBI ID   WP_011054671.1    Uniprot ID   Q4VUT1
Organism   Streptococcus pyogenes strain Isolate 20     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1164190..1198678 1164190..1164372 within 0


Gene organization within MGE regions


Location: 1164190..1198678
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB333_RS05850 (ACB333_05855) prx 1164190..1164372 (-) 183 WP_011054671.1 hypothetical protein Regulator
  ACB333_RS05855 (ACB333_05860) - 1164439..1165233 (-) 795 WP_002983479.1 DNA/RNA non-specific endonuclease -
  ACB333_RS05860 (ACB333_05865) - 1165478..1166692 (-) 1215 WP_002983477.1 peptidoglycan amidohydrolase family protein -
  ACB333_RS05865 (ACB333_05870) - 1166804..1167259 (-) 456 WP_002983475.1 phage holin family protein -
  ACB333_RS05870 (ACB333_05875) - 1167270..1167884 (-) 615 WP_011054672.1 DUF1366 domain-containing protein -
  ACB333_RS05875 (ACB333_05880) - 1167887..1168318 (-) 432 WP_011054673.1 DUF1617 family protein -
  ACB333_RS05880 (ACB333_05885) - 1168327..1170108 (-) 1782 WP_011054674.1 gp58-like family protein -
  ACB333_RS05885 (ACB333_05890) - 1170123..1171232 (-) 1110 WP_011054675.1 hyaluronoglucosaminidase -
  ACB333_RS05890 (ACB333_05895) - 1171232..1173205 (-) 1974 WP_032461270.1 phage tail spike protein -
  ACB333_RS05895 (ACB333_05900) - 1173187..1173882 (-) 696 WP_371392479.1 hypothetical protein -
  ACB333_RS05900 (ACB333_05905) - 1173879..1176242 (-) 2364 WP_371392481.1 hypothetical protein -
  ACB333_RS05905 (ACB333_05910) - 1176242..1176613 (-) 372 WP_011054678.1 DUF5361 domain-containing protein -
  ACB333_RS05910 (ACB333_05915) - 1176628..1176891 (-) 264 WP_010922455.1 hypothetical protein -
  ACB333_RS05915 (ACB333_05920) - 1176902..1177492 (-) 591 WP_011054679.1 hypothetical protein -
  ACB333_RS05920 (ACB333_05925) - 1177508..1177843 (-) 336 WP_000573598.1 hypothetical protein -
  ACB333_RS05925 (ACB333_05930) - 1177844..1178080 (-) 237 WP_000032787.1 hypothetical protein -
  ACB333_RS05930 (ACB333_05935) - 1178073..1178411 (-) 339 WP_011054681.1 hypothetical protein -
  ACB333_RS05935 (ACB333_05940) - 1178371..1178793 (-) 423 WP_011054682.1 phage Gp19/Gp15/Gp42 family protein -
  ACB333_RS05940 (ACB333_05945) - 1178803..1179003 (-) 201 WP_010922460.1 hypothetical protein -
  ACB333_RS05945 (ACB333_05950) - 1179003..1179914 (-) 912 WP_011054683.1 phage major capsid protein -
  ACB333_RS05950 (ACB333_05955) - 1179939..1180400 (-) 462 WP_011054684.1 DUF4355 domain-containing protein -
  ACB333_RS05955 (ACB333_05960) - 1180481..1181896 (-) 1416 WP_011054685.1 terminase -
  ACB333_RS05960 (ACB333_05965) - 1181978..1182193 (-) 216 WP_011106704.1 hypothetical protein -
  ACB333_RS05965 (ACB333_05970) - 1182195..1182461 (-) 267 WP_002986828.1 hypothetical protein -
  ACB333_RS05970 (ACB333_05975) - 1182454..1182606 (-) 153 WP_011054687.1 hypothetical protein -
  ACB333_RS05975 (ACB333_05980) - 1182683..1182907 (-) 225 WP_002994100.1 hypothetical protein -
  ACB333_RS05980 (ACB333_05985) - 1182913..1184406 (-) 1494 WP_010922467.1 hypothetical protein -
  ACB333_RS05985 (ACB333_05990) - 1184399..1185667 (-) 1269 WP_010922468.1 phage portal protein -
  ACB333_RS05990 (ACB333_05995) - 1185664..1186020 (-) 357 WP_002994106.1 hypothetical protein -
  ACB333_RS05995 (ACB333_06000) - 1186168..1186512 (-) 345 WP_011054690.1 HNH endonuclease signature motif containing protein -
  ACB333_RS06000 (ACB333_06005) - 1186620..1187039 (-) 420 WP_011054691.1 DUF1492 domain-containing protein -
  ACB333_RS06005 (ACB333_06010) - 1187115..1187366 (-) 252 WP_011054692.1 hypothetical protein -
  ACB333_RS06010 (ACB333_06015) - 1187363..1187518 (-) 156 WP_011054693.1 hypothetical protein -
  ACB333_RS06015 (ACB333_06020) - 1187515..1187832 (-) 318 WP_011054694.1 DUF1372 family protein -
  ACB333_RS06020 (ACB333_06025) - 1187868..1188380 (-) 513 WP_011054695.1 hypothetical protein -
  ACB333_RS06025 (ACB333_06030) - 1188377..1188709 (-) 333 WP_011054696.1 hypothetical protein -
  ACB333_RS06030 (ACB333_06035) - 1188720..1190066 (-) 1347 WP_011054697.1 PcfJ domain-containing protein -
  ACB333_RS06035 (ACB333_06040) - 1190063..1190458 (-) 396 WP_011054698.1 Cas9 inhibitor AcrIIA9 family protein -
  ACB333_RS06040 (ACB333_06045) - 1190823..1191620 (-) 798 WP_011054699.1 PD-(D/E)XK nuclease-like domain-containing protein -
  ACB333_RS06045 (ACB333_06050) - 1191613..1191813 (-) 201 WP_000594115.1 hypothetical protein -
  ACB333_RS06050 (ACB333_06055) - 1191810..1192736 (-) 927 WP_011054700.1 recombinase RecT -
  ACB333_RS06055 (ACB333_06060) - 1192739..1193069 (-) 331 Protein_1159 hypothetical protein -
  ACB333_RS06060 (ACB333_06065) - 1193125..1193331 (-) 207 WP_002988357.1 hypothetical protein -
  ACB333_RS06065 (ACB333_06070) - 1193340..1193480 (-) 141 WP_002988354.1 hypothetical protein -
  ACB333_RS06070 (ACB333_06075) - 1193477..1193710 (-) 234 WP_010922205.1 hypothetical protein -
  ACB333_RS06075 (ACB333_06080) - 1193691..1194077 (-) 387 WP_011017564.1 DnaD domain-containing protein -
  ACB333_RS06080 (ACB333_06085) - 1194218..1194487 (-) 270 WP_011106700.1 replication protein -
  ACB333_RS06085 (ACB333_06090) - 1194581..1194766 (-) 186 WP_010922477.1 hypothetical protein -
  ACB333_RS06090 (ACB333_06095) - 1194768..1195079 (-) 312 WP_010922478.1 excisionase -
  ACB333_RS06095 (ACB333_06100) - 1195349..1195561 (-) 213 WP_010922479.1 helix-turn-helix domain-containing protein -
  ACB333_RS06100 (ACB333_06105) - 1195763..1196518 (+) 756 WP_010922480.1 XRE family transcriptional regulator -
  ACB333_RS06105 (ACB333_06110) - 1196530..1197048 (+) 519 WP_010922481.1 HIRAN domain-containing protein -
  ACB333_RS06110 (ACB333_06115) - 1197172..1198314 (+) 1143 WP_003051793.1 site-specific integrase -
  ACB333_RS06115 (ACB333_06120) - 1198403..1198678 (-) 276 WP_002983920.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6978.99 Da        Isoelectric Point: 4.3466

>NTDB_id=1037370 ACB333_RS05850 WP_011054671.1 1164190..1164372(-) (prx) [Streptococcus pyogenes strain Isolate 20]
MLTYDEFKQAIDRGYITADTVMIVRKNGQIFDYVLPNEKIKNGEIVTDEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=1037370 ACB333_RS05850 WP_011054671.1 1164190..1164372(-) (prx) [Streptococcus pyogenes strain Isolate 20]
ATGCTAACATACGACGAATTTAAGCAAGCTATTGACCGTGGATATATCACAGCAGACACAGTAATGATCGTGCGCAAGAA
CGGACAGATTTTTGATTATGTGTTGCCGAATGAGAAGATAAAGAATGGAGAAATTGTGACAGACGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4VUT1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

100

100

1
  prx Streptococcus pyogenes MGAS8232

85

100

0.85
  prx Streptococcus pyogenes MGAS315

78.333

100

0.783
  prx Streptococcus pyogenes MGAS315

73.333

100

0.733
  prx Streptococcus pyogenes MGAS315

83.721

71.667

0.6
  prx Streptococcus pyogenes MGAS315

82.927

68.333

0.567
  prx Streptococcus pyogenes MGAS315

71.429

70

0.5

Multiple sequence alignment