Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACB350_RS05250 Genome accession   NZ_CP166999
Coordinates   1005144..1005818 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 34     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1000144..1010818
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB350_RS05225 (ACB350_05225) - 1000590..1000979 (-) 390 WP_002984531.1 cytidine deaminase -
  ACB350_RS05230 (ACB350_05230) - 1001633..1002226 (-) 594 WP_002989699.1 class I SAM-dependent methyltransferase -
  ACB350_RS05235 (ACB350_05235) coaA 1002494..1003414 (+) 921 WP_010922353.1 type I pantothenate kinase -
  ACB350_RS05240 (ACB350_05240) rpsT 1003468..1003716 (+) 249 WP_371396214.1 30S ribosomal protein S20 -
  ACB350_RS05245 (ACB350_05245) ciaH 1003841..1005151 (-) 1311 WP_011054528.1 cell wall metabolism sensor histidine kinase WalK Regulator
  ACB350_RS05250 (ACB350_05250) ciaR 1005144..1005818 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  ACB350_RS05255 (ACB350_05255) - 1006165..1008702 (-) 2538 WP_030127235.1 M1 family metallopeptidase -
  ACB350_RS05260 (ACB350_05260) phoU 1008907..1009560 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  ACB350_RS05265 (ACB350_05265) pstB 1009628..1010386 (-) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=1036762 ACB350_RS05250 WP_002984519.1 1005144..1005818(-) (ciaR) [Streptococcus pyogenes strain Isolate 34]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1036762 ACB350_RS05250 WP_002984519.1 1005144..1005818(-) (ciaR) [Streptococcus pyogenes strain Isolate 34]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment