Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   AB6M99_RS05750 Genome accession   NZ_CP163513
Coordinates   1234040..1234714 (-) Length   224 a.a.
NCBI ID   WP_121834665.1    Uniprot ID   A0A3L9DUV2
Organism   Streptococcus hillyeri strain S23-3001-2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1229040..1239714
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB6M99_RS05725 (AB6M99_05725) - 1229661..1230254 (-) 594 WP_121834669.1 class I SAM-dependent methyltransferase -
  AB6M99_RS05730 (AB6M99_05730) coaA 1230502..1231422 (+) 921 WP_121834668.1 type I pantothenate kinase -
  AB6M99_RS05735 (AB6M99_05735) rpsT 1231457..1231723 (+) 267 WP_121834727.1 30S ribosomal protein S20 -
  AB6M99_RS05740 (AB6M99_05740) - 1231774..1232295 (+) 522 WP_121834667.1 AAA family ATPase -
  AB6M99_RS05745 (AB6M99_05745) ciaH 1232740..1234047 (-) 1308 WP_121834666.1 cell wall metabolism sensor histidine kinase WalK Regulator
  AB6M99_RS05750 (AB6M99_05750) ciaR 1234040..1234714 (-) 675 WP_121834665.1 response regulator transcription factor Regulator
  AB6M99_RS05755 (AB6M99_05755) - 1235021..1237552 (-) 2532 WP_121834664.1 M1 family metallopeptidase -
  AB6M99_RS05760 (AB6M99_05760) phoU 1237774..1238427 (-) 654 WP_121834663.1 phosphate signaling complex protein PhoU -
  AB6M99_RS05765 (AB6M99_05765) pstB 1238458..1239216 (-) 759 WP_121834662.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25290.96 Da        Isoelectric Point: 4.2854

>NTDB_id=1030296 AB6M99_RS05750 WP_121834665.1 1234040..1234714(-) (ciaR) [Streptococcus hillyeri strain S23-3001-2]
MIKILLVEDDLSLSNSVFDFLDDGFADVIQVFDGAEGIYEAESGIYDLILLDLMLPEKNGFQVLKEIREKGITTPVLIMT
AKESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKLTDNNLVYGNVSVDLTTNRTTVDDAEVELLGKEFELLV
YFLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGSDFGENLQTLRSVGYILKNG

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1030296 AB6M99_RS05750 WP_121834665.1 1234040..1234714(-) (ciaR) [Streptococcus hillyeri strain S23-3001-2]
ATGATTAAAATTTTACTTGTTGAAGATGATTTGAGTTTATCAAATTCTGTGTTTGATTTTTTAGATGATGGTTTTGCTGA
TGTCATACAGGTTTTTGATGGTGCTGAGGGTATTTATGAAGCTGAATCAGGTATTTATGATTTAATCCTTTTAGACCTCA
TGTTGCCTGAAAAAAATGGGTTTCAGGTGTTGAAAGAAATACGTGAAAAGGGGATTACAACCCCAGTTCTTATCATGACA
GCTAAAGAAAGTCTTGATGATAAGGGGCATGGCTTTGAATTAGGGGCGGATGATTACCTCACAAAGCCATTCTACCTAGA
AGAGTTAAAAATGCGTATACAAGCACTATTGAAGCGTTCTGGGAAATTAACAGATAATAACCTGGTTTATGGAAATGTCT
CTGTCGATTTGACGACCAATAGAACAACTGTTGATGATGCTGAAGTGGAATTATTGGGTAAAGAATTTGAATTGCTGGTT
TATTTCTTGCAAAACCAGAATGTTATCCTGCCTAAGACACAAATTTTTGATCGTCTGTGGGGATTTGACAGTGATACCAC
AATTTCTGTTGTCGAGGTTTATGTGTCTAAAATTCGTAAAAAATTAAAAGGGTCTGATTTTGGAGAGAACCTTCAAACCT
TGCGAAGTGTGGGGTATATTTTAAAAAATGGTTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-221)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3L9DUV2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae D39

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae R6

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.996

99.554

0.866
  ciaR Streptococcus mutans UA159

85.714

100

0.857
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

34.468

100

0.362
  micA Streptococcus pneumoniae Cp1015

34.615

100

0.362

Multiple sequence alignment