Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   AB4X21_RS04585 Genome accession   NZ_CP163380
Coordinates   883180..883860 (+) Length   226 a.a.
NCBI ID   WP_037607818.1    Uniprot ID   A0A2I1TVC1
Organism   Streptococcus sp. CP1998     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 878180..888860
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB4X21_RS04565 (AB4X21_04565) phoU 878383..879036 (+) 654 WP_227038097.1 phosphate signaling complex protein PhoU -
  AB4X21_RS04570 (AB4X21_04570) - 879166..881708 (+) 2543 Protein_848 M1 family metallopeptidase -
  AB4X21_RS04575 (AB4X21_04575) - 881765..882298 (-) 534 WP_129824198.1 biotin transporter BioY -
  AB4X21_RS04580 (AB4X21_04580) - 882505..883044 (+) 540 WP_369088268.1 hypothetical protein -
  AB4X21_RS04585 (AB4X21_04585) ciaR 883180..883860 (+) 681 WP_037607818.1 response regulator transcription factor Regulator
  AB4X21_RS04590 (AB4X21_04590) ciaH 883844..885205 (+) 1362 WP_369088269.1 sensor histidine kinase Regulator
  AB4X21_RS04595 (AB4X21_04595) - 885235..885615 (+) 381 WP_003003384.1 VOC family protein -
  AB4X21_RS04600 (AB4X21_04600) - 885725..887107 (+) 1383 WP_369088270.1 polysaccharide deacetylase family protein -
  AB4X21_RS04605 (AB4X21_04605) - 887150..888235 (-) 1086 WP_369088271.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25709.43 Da        Isoelectric Point: 4.3559

>NTDB_id=1029432 AB4X21_RS04585 WP_037607818.1 883180..883860(+) (ciaR) [Streptococcus sp. CP1998]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVESLQTLRSVGYILKDANQN

Nucleotide


Download         Length: 681 bp        

>NTDB_id=1029432 AB4X21_RS04585 WP_037607818.1 883180..883860(+) (ciaR) [Streptococcus sp. CP1998]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTATCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGACGT
CATGCAGGTCTTTGACGGAGAAGAAGGTCTTTACGAAGCTGAAAGCGGGATCTATGATTTGATTTTGCTGGACCTGATGC
TTCCTGAAAAAGACGGTTTCCATGTCTTGAAAGAATTGCGTGAAAAAGGCGTGACAACCCCTGTTCTGATCATGACAGCC
AAAGAAAGTCTGGATGACAAGGGACACGGCTTTGAGCTGGGAGCAGACGATTACCTCACCAAGCCTTTCTACCTAGAAGA
GCTCAAGATGCGGATTCAAGCCCTCTTGAAACGCTCAGGAAAGGTCAATGAAAACACCCTTAATTATGGCAATTTGAAGG
TCAACTTATCTACCAATTCAACTTATGTGGATGGGAAAGAAGTGGAACTTCTCGGGAAGGAATTTGATCTCTTGGTCTAC
TTTCTTCAAAACCAAAATGTCATCCTTCCAAAAACACAGATTTTCGATCGTCTCTGGGGTTTTGACAGTGATACAACCAT
CTCTGTTGTTGAGGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGTACCGATTTCGTTGAGAGCTTGCAAACATTGC
GCAGTGTGGGGTATATCTTAAAAGATGCTAACCAGAATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2I1TVC1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae D39

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae R6

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae TIGR4

90.179

99.115

0.894
  ciaR Streptococcus mutans UA159

88.393

99.115

0.876
  vicR Streptococcus mutans UA159

36.481

100

0.376
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.889

99.558

0.367
  covR Streptococcus salivarius strain HSISS4

36.123

100

0.363

Multiple sequence alignment