Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ABKA15_RS03900 Genome accession   NZ_CP157941
Coordinates   788721..789395 (+) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus sp. KHUD_010     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 783721..794395
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABKA15_RS03880 (ABKA15_03875) - 786021..786980 (+) 960 WP_003027901.1 ROK family glucokinase -
  ABKA15_RS03885 (ABKA15_03880) rplS 787131..787478 (+) 348 WP_049512881.1 50S ribosomal protein L19 -
  ABKA15_RS03895 (ABKA15_03890) - 787994..788449 (+) 456 WP_003029592.1 hypothetical protein -
  ABKA15_RS03900 (ABKA15_03895) ciaR 788721..789395 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  ABKA15_RS03905 (ABKA15_03900) ciaH 789385..790731 (+) 1347 WP_049512879.1 HAMP domain-containing sensor histidine kinase Regulator
  ABKA15_RS03910 (ABKA15_03905) - 791120..792568 (-) 1449 WP_049512877.1 alpha-amylase -
  ABKA15_RS03915 (ABKA15_03910) - 792745..794358 (+) 1614 WP_049512875.1 M20/M25/M40 family metallo-hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=1009113 ABKA15_RS03900 WP_003024352.1 788721..789395(+) (ciaR) [Streptococcus sp. KHUD_010]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1009113 ABKA15_RS03900 WP_003024352.1 788721..789395(+) (ciaR) [Streptococcus sp. KHUD_010]
ATGATTAAGATTCTATTAGTGGAAGACGATCTCGGTCTATCTAATTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
TATGCAAGTTTTTGATGGTGAGGAAGGATTGTATGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGACTTGATGC
TGCCAGAAAAAGACGGCTTCCAAGTGTTGAAAGAATTGCGTGAAAAAGGTGTCACAACTCCTGTGCTAATCATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGTGCTGATGATTATTTGACCAAACCATTTTATTTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTGTTGAAGCGTTCTGGCAAGTTTAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACTAACACAACACTTGTAGATGGAAACGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTCATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTCGTAGAAGTCTATGTTTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment