Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ABKA15_RS03905 Genome accession   NZ_CP157941
Coordinates   789385..790731 (+) Length   448 a.a.
NCBI ID   WP_049512879.1    Uniprot ID   A0A7L8W9L6
Organism   Streptococcus sp. KHUD_010     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 784385..795731
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABKA15_RS03880 (ABKA15_03875) - 786021..786980 (+) 960 WP_003027901.1 ROK family glucokinase -
  ABKA15_RS03885 (ABKA15_03880) rplS 787131..787478 (+) 348 WP_049512881.1 50S ribosomal protein L19 -
  ABKA15_RS03895 (ABKA15_03890) - 787994..788449 (+) 456 WP_003029592.1 hypothetical protein -
  ABKA15_RS03900 (ABKA15_03895) ciaR 788721..789395 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  ABKA15_RS03905 (ABKA15_03900) ciaH 789385..790731 (+) 1347 WP_049512879.1 HAMP domain-containing sensor histidine kinase Regulator
  ABKA15_RS03910 (ABKA15_03905) - 791120..792568 (-) 1449 WP_049512877.1 alpha-amylase -
  ABKA15_RS03915 (ABKA15_03910) - 792745..794358 (+) 1614 WP_049512875.1 M20/M25/M40 family metallo-hydrolase -
  ABKA15_RS03920 (ABKA15_03915) - 794407..794916 (-) 510 WP_049512874.1 DNA topology modulation protein -
  ABKA15_RS03925 (ABKA15_03920) rpsT 794980..795231 (-) 252 WP_020999623.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 51017.77 Da        Isoelectric Point: 10.1292

>NTDB_id=1009114 ABKA15_RS03905 WP_049512879.1 789385..790731(+) (ciaH) [Streptococcus sp. KHUD_010]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGLEQKSDNEE
PKADTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGREETYRTILFKVKLPN
LETNVKYAAVFINTSQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTILANDRTLFLKVADNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1009114 ABKA15_RS03905 WP_049512879.1 789385..790731(+) (ciaH) [Streptococcus sp. KHUD_010]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
CTTCTCAGCCATGACTTTGATCATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGTAGAGTAGGGCTGGAACAGAAGTCAGACAACGAAGAG
CCTAAAGCCGATACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCTAATACGGAAGTTATCTTATTTGATAA
GAATTACAAGCCGATTATTACTAGCAATAATTTTCTGGGACTTAACAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTTCAAGTAAAAAGCAATTATGGGCGTGAAGAAACCTATCGGACGATTTTATTTAAGGTGAAATTGCCTAAT
TTGGAAACGAACGTTAAATACGCAGCGGTCTTTATCAATACCAGCCAATTGGAACAAACCAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTAATGATTAGTTTCTGGGGAATTTCTTTGATTGCAAGTGTCTATCTGGCTCGTGTCAGTGTTAAACCTT
TGTTGGAGAGTATTCAAAAGCAAAAGAGCTTTGTTGAAAATGCTAGTCACGAGTTGCGGACGCCTCTAGCAGTTTTGCAA
AATCGCTTGGAAACCTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGACGA
AGTCCGGAACATGAAAATGTTGACGACAAATCTACTCAATCTAGCACGACGCGATGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAGATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTGATGACAATTCTGTTTGATAATGCCTT
GAAATATACAGATGAAGACGGTGTAATTGAGTTGACGATTTTAGCGAATGACCGAACCCTTTTTTTGAAAGTTGCAGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGAACTCGGCAG
ACAGGCGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCCCTTAAAGGGACTATTACGGTGAAAGATAA
TAAGCCGAAAGGAACCATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7L8W9L6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.205

100

0.712
  ciaH Streptococcus pneumoniae D39

71.205

100

0.712
  ciaH Streptococcus pneumoniae R6

71.205

100

0.712
  ciaH Streptococcus pneumoniae TIGR4

71.205

100

0.712
  ciaH Streptococcus mutans UA159

56.818

98.214

0.558

Multiple sequence alignment