Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   E0F31_RS10325 Genome accession   NZ_LR216064
Coordinates   1904699..1905139 (-) Length   146 a.a.
NCBI ID   WP_001206584.1    Uniprot ID   A0A0H2ZQ34
Organism   Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1899699..1910139
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F31_RS10295 (SAMEA3714520_01942) - 1900009..1900884 (+) 876 WP_000669498.1 substrate-binding domain-containing protein -
  E0F31_RS10300 (SAMEA3714520_01943) pstC 1901002..1901865 (+) 864 WP_000165887.1 phosphate ABC transporter permease subunit PstC -
  E0F31_RS10305 (SAMEA3714520_01944) pstA 1901858..1902673 (+) 816 WP_000049768.1 phosphate ABC transporter permease PstA -
  E0F31_RS10310 (SAMEA3714520_01945) pstB 1902675..1903427 (+) 753 WP_000536449.1 phosphate ABC transporter ATP-binding protein PstB -
  E0F31_RS10315 (SAMEA3714520_01946) phoU 1903442..1904092 (+) 651 WP_001245781.1 phosphate signaling complex protein PhoU -
  E0F31_RS10320 (SAMEA3714520_01947) - 1904133..1904576 (+) 444 Protein_1936 transposase -
  E0F31_RS10325 (SAMEA3714520_01948) comR 1904699..1905139 (-) 441 WP_001206584.1 helix-turn-helix domain-containing protein Regulator
  E0F31_RS10330 (SAMEA3714520_01949) - 1905351..1906367 (+) 1017 WP_000415108.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  E0F31_RS10335 (SAMEA3714520_01950) galU 1906389..1907288 (+) 900 WP_000202229.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
  E0F31_RS10340 (SAMEA3714520_01951) - 1907355..1908032 (-) 678 WP_000658498.1 rhomboid family intramembrane serine protease -
  E0F31_RS10345 (SAMEA3714520_01952) - 1908016..1908555 (-) 540 WP_000834319.1 5-formyltetrahydrofolate cyclo-ligase -
  E0F31_RS10350 (SAMEA3714520_01953) - 1908567..1909697 (-) 1131 WP_000886112.1 N-acetyldiaminopimelate deacetylase -

Sequence

Protein


Download         Length: 146 a.a.        Molecular weight: 17716.41 Da        Isoelectric Point: 4.8659

>NTDB_id=1004029 E0F31_RS10325 WP_001206584.1 1904699..1905139(-) (comR) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MREFGEKIKRLRLAKKISRSEFCGDESELSIRQLIRIENGESRPTLTKLKYIAERLEVEDYKLMPSYIELDKEYLELKYF
LMRTPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFIIPNYSYLALANYTVQKLPEKLVEILSFW

Nucleotide


Download         Length: 441 bp        

>NTDB_id=1004029 E0F31_RS10325 WP_001206584.1 1904699..1905139(-) (comR) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
TTGCGAGAGTTTGGCGAAAAAATTAAAAGATTACGTTTGGCTAAAAAAATCAGTCGTTCAGAATTTTGTGGTGATGAGTC
TGAATTAAGTATCCGTCAATTAATTAGAATTGAAAATGGAGAATCCAGACCAACACTAACAAAGTTAAAATATATTGCTG
AACGTTTGGAGGTTGAAGATTACAAGTTGATGCCAAGTTATATAGAGTTGGATAAGGAATACCTAGAATTGAAGTATTTC
TTGATGAGGACTCCTACATACGAAGATGAAACTATCGCCCAAAAGAAAGAGAGTGTTTTTGATAAGATTTTTGAAGAGTA
TTATGATAGGCTACCTGAGGAAGAAAGATTTATCATCCCAAATTATTCATATCTAGCACTAGCGAACTACACAGTTCAAA
AATTACCAGAAAAGCTAGTTGAAATACTGTCCTTCTGGTGA

Domains

Predicted by InterProScan.

ComR tetratricopeptide (ComR_TPR)

(72-119)

Helix-turn-helix (HTH_3)

(8-59)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2ZQ34

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

55

82.192

0.452
  comR Streptococcus pyogenes MGAS315

53.333

82.192

0.438
  comR Streptococcus mutans UA159

52.5

82.192

0.432
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

53.636

75.342

0.404
  comR Streptococcus suis P1/7

47.458

80.822

0.384
  comR Streptococcus suis 05ZYH33

47.458

80.822

0.384
  comR Streptococcus suis D9

46.61

80.822

0.377
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

47.368

78.082

0.37