Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/RHH-RelE
Location 2718990..2719444 Replicon chromosome
Accession NC_002696
Organism Caulobacter crescentus CB15

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3CA69
Locus tag CC_RS13115 Protein ID WP_012640512.1
Coordinates 2718990..2719292 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H3CAY6
Locus tag CC_RS13120 Protein ID WP_024265819.1
Coordinates 2719244..2719420 (-) Length 59 a.a.

Genomic Context

CC_RS13080CC_RS13085CC_RS13135CC_RS13090CC_RS13095CC_RS13100CC_RS13105CC_RS13110CC_RS13115CC_RS13120CC_RS13125CC_RS13130CC_RS13140CC_RS13145
Location: 2714574..2714915 (342 bp)
Type: Others
Protein ID: WP_010920362.1
Location: 2714932..2715351 (420 bp)
Type: Others
Protein ID: WP_010920363.1
Location: 2721678..2722556 (879 bp)
Type: Others
Protein ID: WP_010920374.1
Location: 2715751..2716128 (378 bp)
Type: Others
Protein ID: WP_010920365.1
Location: 2716196..2717146 (951 bp)
Type: Others
Protein ID: WP_010920366.1
Location: 2717156..2717476 (321 bp)
Type: Others
Protein ID: WP_010920367.1
Location: 2717741..2718358 (618 bp)
Type: Others
Protein ID: WP_010920368.1
Location: 2718530..2718910 (381 bp)
Type: Others
Protein ID: WP_010920369.1
Location: 2718990..2719292 (303 bp)
Type: Toxin
Protein ID: WP_012640512.1
Location: 2719244..2719420 (177 bp)
Type: Antitoxin
Protein ID: WP_024265819.1
Location: 2719468..2720301 (834 bp)
Type: Others
Protein ID: WP_010920372.1
Location: 2720450..2721559 (1110 bp)
Type: Others
Protein ID: WP_010920373.1
Location: 2722553..2723839 (1287 bp)
Type: Others
Protein ID: WP_012640513.1
Location: 2723921..2724337 (417 bp)
Type: Others
Protein ID: WP_012640514.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CC_RS13080 (CC_2505)2714574..2714915+342WP_010920362.1Grx4 family monothiol glutaredoxin-
CC_RS13085 (CC_2506)2714932..2715351+420WP_010920363.1acyl-CoA thioesterase-
CC_RS13090 (CC_2508)2715751..2716128-378WP_010920365.1hypothetical protein-
CC_RS13095 (CC_2509)2716196..2717146-951WP_010920366.1zinc metalloprotease HtpX-
CC_RS13100 (CC_2510)2717156..2717476-321WP_010920367.1zf-TFIIB domain-containing protein-
CC_RS13105 (CC_2511)2717741..2718358-618WP_010920368.130S ribosomal protein S4-
CC_RS13110 (CC_2512)2718530..2718910-381WP_010920369.1hypothetical protein-
CC_RS13115 (CC_2513)2718990..2719292-303WP_012640512.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CC_RS13120 (CC_2514)2719244..2719420-177WP_024265819.1antitoxin protein relB-2Antitoxin
CC_RS13125 (CC_2515)2719468..2720301-834WP_010920372.1S-formylglutathione hydrolase-
CC_RS13130 (CC_2516)2720450..2721559-1110WP_010920373.1S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase-
CC_RS13135 (CC_2517)2721678..2722556+879WP_010920374.1LysR family transcriptional regulator-
CC_RS13140 (CC_2518)2722553..2723839-1287WP_012640513.1DUF1254 domain-containing protein-
CC_RS131452723921..2724337-417WP_012640514.1host attachment protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(15-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11329.25 Da        Isoelectric Point: 11.2666

>T229 WP_012640512.1 NC_002696:c2719292-2718990 [Caulobacter vibrioides CB15]
MGDARRKARARDVAQVVWTWRALADLTAIRDYIGQFSPLAAQRMALRLKTAADSLAEYPERGRLATATLRELVVVPPYVI
RYYVADGLVHIVRIRHAARL

Download         Length: 303 bp

>T229 NC_002696:c2719292-2718990 [Caulobacter vibrioides CB15]
TTGGGGGACGCCCGAAGAAAAGCCCGCGCCCGAGACGTGGCGCAAGTAGTCTGGACTTGGCGTGCGCTGGCCGATCTGAC
GGCTATCCGCGACTATATTGGCCAATTCAGCCCGCTCGCGGCCCAGCGCATGGCTTTACGGCTCAAGACCGCTGCTGACA
GCCTAGCGGAGTATCCCGAGCGCGGCCGCCTAGCAACAGCGACGCTCCGGGAGTTGGTCGTCGTTCCACCCTATGTGATC
CGCTATTATGTGGCTGACGGTCTGGTGCATATCGTCCGCATCCGGCACGCCGCCCGGTTGTGA

Antitoxin


Download         Length: 59 a.a.        Molecular weight: 6363.99 Da        Isoelectric Point: 3.7930

>AT229 WP_024265819.1 NC_002696:c2719420-2719244 [Caulobacter vibrioides CB15]
MVPEPSIFEIDAEAEEAADAEGMADIAAGRVVPHEEVSAWLDTWGTPEEKPAPETWRK

Download         Length: 177 bp

>AT229 NC_002696:c2719420-2719244 [Caulobacter vibrioides CB15]
ATGGTCCCCGAGCCGTCCATCTTCGAGATTGACGCGGAAGCCGAAGAGGCCGCCGATGCGGAAGGCATGGCCGACATCGC
AGCCGGCCGCGTTGTACCCCACGAAGAGGTCTCCGCCTGGCTCGACACTTGGGGGACGCCCGAAGAAAAGCCCGCGCCCG
AGACGTGGCGCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T1008Escherichia coli O157:H7 str. Sakai

37.5

95.652

0.359

T10119Escherichia coli

36.364

95.652

0.348

T10143Pseudomonas savastanoi

36.047

93.478

0.337

T1006Escherichia coli O157:H7 str. Sakai

36.364

92.632

0.337

T226Caulobacter crescentus CB15

37.5

86.022

0.323

T178Vibrio cholerae O1 biovar El Tor str. N16961

34.066

91

0.31

T6097Sinorhizobium meliloti 1021

34.483

89.691

0.309

T10139Pseudomonas savastanoi

34.568

89.011

0.308
Showing 1 to 8 of 8 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3CA69

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3CAY6

References

(1) Aretha Fiebig et al. (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Molecular Microbiology 77(1):236-51. [PubMed:20487277] experimental


experimental experimental literature