Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/RHH-RelE
Location 1167455..1167933 Replicon chromosome
Accession NC_002695
Organism Escherichia coli O157:H7 str. Sakai

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag ECs_1067 Protein ID NP_309094.1
Coordinates 1167456..1167743 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag ECs_1068 Protein ID NP_309095.1
Coordinates 1167743..1167934 (-) Length 64 a.a.

Regulator (Protein)


Gene name paaR Uniprot ID -
Locus tag ECs_1069 Protein ID NP_309096.2
Coordinates 1167962..1168363 (-) Length 134 a.a.

Genomic Context

ECs_1061ECs_1070ECs_1071ECs_1073ECs_1074ECs_1075ECs_1057ECs_1058ECs_1059ECs_1063ECs_1064ECs_1065ECs_1067ECs_1068ECs_1069ECs_5703
Location: 1166120..1166305 (186 bp)
Type: Others
Protein ID: NP_309088.1
Location: 1168472..1168744 (273 bp)
Type: Others
Protein ID: NP_309097.1
Location: 1168728..1169153 (426 bp)
Type: Others
Protein ID: NP_309098.1
Location: 1169894..1170985 (1092 bp)
Type: Others
Protein ID: NP_309100.1
Location: 1170992..1171738 (747 bp)
Type: Others
Protein ID: NP_309101.1
Location: 1171760..1172530 (771 bp)
Type: Others
Protein ID: NP_309102.1
Location: 1162605..1165076 (2472 bp)
Type: Others
Protein ID: NP_309084.1
Location: 1165170..1165361 (192 bp)
Type: Others
Protein ID: NP_309085.1
Location: 1165358..1165546 (189 bp)
Type: Others
Protein ID: NP_309086.1
Location: 1166492..1166881 (390 bp)
Type: Others
Protein ID: NP_309090.1
Location: 1166893..1167021 (129 bp)
Type: Others
Protein ID: NP_303797.1
Location: 1167023..1167178 (156 bp)
Type: Others
Protein ID: NP_309092.1
Location: 1167456..1167743 (288 bp)
Type: Toxin
Protein ID: NP_309094.1
Location: 1167743..1167934 (192 bp)
Type: Antitoxin
Protein ID: NP_309095.1
Location: 1167962..1168363 (402 bp)
Type: Regulator
Protein ID: NP_309096.2
Location: 1169360..1169815 (456 bp)
Type: Others
Protein ID: YP_009502597.1
ToxinAntitoxinRegulatorOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECs_10571162605..1165076-2472NP_309084.1exonuclease-
ECs_10581165170..1165361-192NP_309085.1hypothetical protein-
ECs_10591165358..1165546-189NP_309086.1cell division inhibition protein-
ECs_10611166120..1166305+186NP_309088.1hypothetical protein-
ECs_10631166492..1166881-390NP_309090.1hypothetical protein-
ECs_10641166893..1167021-129NP_303797.1hypothetical protein-
ECs_10651167023..1167178-156NP_309092.1hypothetical protein-
ECs_10671167456..1167743-288NP_309094.1plasmid stabilization system proteinToxin
ECs_10681167743..1167934-192NP_309095.1hypothetical proteinAntitoxin
ECs_10691167962..1168363-402NP_309096.2phage repressor proteinRegulator
ECs_10701168472..1168744+273NP_309097.1hypothetical protein-
ECs_10711168728..1169153+426NP_309098.1hypothetical protein-
ECs_57031169360..1169815-456YP_009502597.1hypothetical protein-
ECs_10731169894..1170985+1092NP_309100.1phage replication protein-
ECs_10741170992..1171738+747NP_309101.1phage DNA replication protein-
ECs_10751171760..1172530+771NP_309102.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T1006 NP_309094.1 NC_002695:c1167743-1167456 [Escherichia coli O157:H7 str. Sakai]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T1006 NC_002695:c1167743-1167456 [Escherichia coli O157:H7 str. Sakai]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT1006 NP_309095.1 NC_002695:c1167934-1167743 [Escherichia coli O157:H7 str. Sakai]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT1006 NC_002695:c1167934-1167743 [Escherichia coli O157:H7 str. Sakai]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Regulator


Download         Length: 134 a.a.        Molecular weight: 15301.65 Da        Isoelectric Point: 8.0365

>RE1006 NP_309096.2 NC_002695:c1168363-1167962 [Escherichia coli O157:H7 str. Sakai]
MMSALEVSMYRISKLLQETGWSQAELARRIGVTQQTVQQWVSGKATPKASSLDKLVEVSGHPLHWFLLPPEECEQIFTPD
TMKIGPRQRELLQAFSAFPEEDQEKMLQEIKDKKKSMEETIARWLAAQKSRRA

Download         Length: 402 bp

>RE1006 NC_002695:c1168363-1167962 [Escherichia coli O157:H7 str. Sakai]
ATGATGAGCGCCCTAGAAGTATCTATGTACAGAATCAGCAAGCTTCTTCAGGAAACTGGATGGAGCCAGGCTGAGCTTGC
CCGTAGAATTGGTGTGACACAACAAACTGTTCAACAATGGGTCAGCGGTAAGGCTACACCTAAAGCCTCAAGTTTGGATA
AACTGGTTGAGGTTTCAGGGCATCCATTGCATTGGTTTTTATTGCCTCCTGAAGAGTGTGAGCAAATTTTCACCCCTGAC
ACGATGAAAATTGGTCCTCGCCAACGCGAACTGCTCCAAGCTTTTAGTGCGTTTCCTGAGGAAGACCAAGAAAAAATGCT
TCAAGAAATCAAAGACAAGAAAAAATCAATGGAAGAAACCATTGCTAGGTGGCTGGCGGCACAAAAAAGCCGCCGGGCGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T1008Escherichia coli O157:H7 str. Sakai

67.391

100

0.674

T10141Pseudomonas savastanoi

56.522

96.842

0.547

T10143Pseudomonas savastanoi

46.154

98.913

0.457

T10139Pseudomonas savastanoi

40.217

100

0.407

T10119Escherichia coli

34.409

100

0.348

T229Caulobacter crescentus CB15

36.364

92.632

0.337

T6097Sinorhizobium meliloti 1021

33.696

96.842

0.326

T178Vibrio cholerae O1 biovar El Tor str. N16961

31.183

97.895

0.305
Showing 1 to 8 of 8 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT1008Escherichia coli O157:H7 str. Sakai

69.643

88.889

0.619

AT10141Pseudomonas savastanoi

60.784

83.607

0.508

AT10143Pseudomonas savastanoi

60.784

80.952

0.492

AT10139Pseudomonas savastanoi

52.727

87.302

0.46
Showing 1 to 4 of 4 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Régis Hallez et al. (2010) New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Molecular Microbiology 76(3):719-32. [PubMed:20345661] experimental


experimental experimental literature