Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH-RelE |
| Location | 890690..891231 | Replicon | chromosome |
| Accession | NC_002696 | ||
| Organism | Caulobacter crescentus CB15 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9AA09 |
| Locus tag | CC_RS04185 | Protein ID | WP_010918687.1 |
| Coordinates | 890690..890971 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9AA08 |
| Locus tag | CC_RS04190 | Protein ID | WP_010918688.1 |
| Coordinates | 890968..891231 (-) | Length | 88 a.a. |
Genomic Context
Location: 894444..894605 (162 bp)
Type: Others
Protein ID: WP_024265629.1
Type: Others
Protein ID: WP_024265629.1
Location: 894805..895272 (468 bp)
Type: Others
Protein ID: WP_010918690.1
Type: Others
Protein ID: WP_010918690.1
Location: 885772..887388 (1617 bp)
Type: Others
Protein ID: WP_012640065.1
Type: Others
Protein ID: WP_012640065.1
Location: 887478..889202 (1725 bp)
Type: Others
Protein ID: WP_010918685.1
Type: Others
Protein ID: WP_010918685.1
Location: 889286..890614 (1329 bp)
Type: Others
Protein ID: WP_010918686.1
Type: Others
Protein ID: WP_010918686.1
Location: 890690..890971 (282 bp)
Type: Toxin
Protein ID: WP_010918687.1
Type: Toxin
Protein ID: WP_010918687.1
Location: 890968..891231 (264 bp)
Type: Antitoxin
Protein ID: WP_010918688.1
Type: Antitoxin
Protein ID: WP_010918688.1
Location: 891270..894359 (3090 bp)
Type: Others
Protein ID: WP_010918689.1
Type: Others
Protein ID: WP_010918689.1
Location: 895299..895463 (165 bp)
Type: Others
Protein ID: WP_024265630.1
Type: Others
Protein ID: WP_024265630.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CC_RS04170 (CC_0799) | 885772..887388 | - | 1617 | WP_012640065.1 | carboxylesterase/lipase family protein | - |
| CC_RS04175 (CC_0800) | 887478..889202 | - | 1725 | WP_010918685.1 | hypothetical protein | - |
| CC_RS04180 (CC_0801) | 889286..890614 | - | 1329 | WP_010918686.1 | mannanase | - |
| CC_RS04185 (CC_0802) | 890690..890971 | - | 282 | WP_010918687.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CC_RS04190 (CC_0803) | 890968..891231 | - | 264 | WP_010918688.1 | type II toxin-antitoxin system antitoxin RelB1 | Antitoxin |
| CC_RS04195 (CC_0804) | 891270..894359 | - | 3090 | WP_010918689.1 | bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA | - |
| CC_RS04200 | 894444..894605 | + | 162 | WP_024265629.1 | hypothetical protein | - |
| CC_RS04205 (CC_0805) | 894805..895272 | + | 468 | WP_010918690.1 | Lrp/AsnC ligand binding domain-containing protein | - |
| CC_RS04210 | 895299..895463 | - | 165 | WP_024265630.1 | leucine-responsive regulatory protein | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10486.14 Da Isoelectric Point: 11.7926
>T226 WP_010918687.1 NC_002696:c890971-890690 [Caulobacter vibrioides CB15]
MTFTVLVSVRAKRDFNRLIVWLVERDPRAAARLGPLLEAALDSLTEAPSRGRSVGPTTREISIPFGQSAYVIRYRLLGSS
VHVTRIWHGLEQR
MTFTVLVSVRAKRDFNRLIVWLVERDPRAAARLGPLLEAALDSLTEAPSRGRSVGPTTREISIPFGQSAYVIRYRLLGSS
VHVTRIWHGLEQR
Download Length: 282 bp
>T226 NC_002696:c890971-890690 [Caulobacter vibrioides CB15]
TTGACCTTCACGGTTTTGGTATCCGTTCGGGCCAAGAGAGACTTCAACCGTCTCATCGTCTGGCTTGTGGAGCGCGACCC
CCGAGCAGCGGCTAGACTGGGCCCACTTCTGGAGGCCGCCCTCGACAGTTTGACCGAGGCGCCATCGCGAGGTCGCTCGG
TTGGTCCCACCACCCGCGAGATCAGCATTCCTTTTGGTCAGAGCGCCTATGTGATCCGCTACCGGCTCCTCGGCTCCAGC
GTACATGTCACCCGGATCTGGCACGGCCTTGAGCAAAGGTAG
TTGACCTTCACGGTTTTGGTATCCGTTCGGGCCAAGAGAGACTTCAACCGTCTCATCGTCTGGCTTGTGGAGCGCGACCC
CCGAGCAGCGGCTAGACTGGGCCCACTTCTGGAGGCCGCCCTCGACAGTTTGACCGAGGCGCCATCGCGAGGTCGCTCGG
TTGGTCCCACCACCCGCGAGATCAGCATTCCTTTTGGTCAGAGCGCCTATGTGATCCGCTACCGGCTCCTCGGCTCCAGC
GTACATGTCACCCGGATCTGGCACGGCCTTGAGCAAAGGTAG
Antitoxin
Download Length: 88 a.a. Molecular weight: 9198.31 Da Isoelectric Point: 4.2560
>AT226 WP_010918688.1 NC_002696:c891231-890968 [Caulobacter vibrioides CB15]
MADGFDIHIDQEQAARLKVVADRLGMSVSEYAVALIDAGLTGAAPKAIDPDPAIDEAIADAIERGDEPAISRDEFRAHIR
RVTAGLG
MADGFDIHIDQEQAARLKVVADRLGMSVSEYAVALIDAGLTGAAPKAIDPDPAIDEAIADAIERGDEPAISRDEFRAHIR
RVTAGLG
Download Length: 264 bp
>AT226 NC_002696:c891231-890968 [Caulobacter vibrioides CB15]
ATGGCCGATGGCTTCGACATTCATATCGATCAAGAGCAGGCCGCCCGGCTGAAGGTCGTTGCCGACCGCCTGGGTATGTC
CGTGTCCGAGTACGCCGTTGCGCTGATCGACGCAGGGCTGACAGGCGCGGCGCCTAAAGCGATCGATCCGGACCCCGCCA
TCGACGAGGCCATCGCCGACGCCATCGAGCGGGGCGACGAGCCGGCGATTTCACGCGATGAGTTCCGCGCTCATATACGT
CGCGTGACTGCGGGCCTGGGTTGA
ATGGCCGATGGCTTCGACATTCATATCGATCAAGAGCAGGCCGCCCGGCTGAAGGTCGTTGCCGACCGCCTGGGTATGTC
CGTGTCCGAGTACGCCGTTGCGCTGATCGACGCAGGGCTGACAGGCGCGGCGCCTAAAGCGATCGATCCGGACCCCGCCA
TCGACGAGGCCATCGCCGACGCCATCGAGCGGGGCGACGAGCCGGCGATTTCACGCGATGAGTTCCGCGCTCATATACGT
CGCGTGACTGCGGGCCTGGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Loading, please wait
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10142 | Pseudomonas savastanoi | 36.264 | 97.849 | 0.355 |
| T229 | Caulobacter crescentus CB15 | 37.5 | 86.022 | 0.323 |
| T10137 | Pseudomonas savastanoi | 31.818 | 94.624 | 0.301 |
Showing 1 to 3 of 3 rows
Multiple sequence alignment
Loading, please wait
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| No matching records found | ||||
References
(1) Aretha Fiebig et al. (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Molecular Microbiology 77(1):236-51. [PubMed:20487277]