20641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1128797..1129404 Replicon plasmid pSymA
Accession NC_003037
Organism Sinorhizobium meliloti 1021

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SM_RS30160 Protein ID WP_017264738.1
Coordinates 1128797..1129051 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID H0G1X1
Locus tag SM_RS30165 Protein ID WP_003530441.1
Coordinates 1129048..1129404 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM_RS30135 (SMa1978) 1124198..1124902 - 705 WP_010968042.1 haloacid dehalogenase type II -
SM_RS30140 (SMa1979) 1124993..1125865 + 873 WP_010968043.1 LysR family transcriptional regulator -
SM_RS30145 1125916..1126071 - 156 WP_017264742.1 hypothetical protein -
SM_RS31495 1126157..1126315 - 159 WP_017276730.1 hypothetical protein -
SM_RS30150 (SMa1985) 1126439..1127479 - 1041 WP_010968044.1 NAD(P)H-binding protein -
SM_RS30155 (SMa1987) 1127568..1128455 + 888 WP_014528000.1 LysR family transcriptional regulator -
SM_RS30160 1128797..1129051 + 255 WP_017264738.1 type II toxin-antitoxin system HicA family toxin Toxin
SM_RS30165 (SMa1990) 1129048..1129404 + 357 WP_003530441.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SM_RS30170 (SMa1993) 1129777..1130433 - 657 WP_010968046.1 SGNH/GDSL hydrolase family protein -
SM_RS30175 (SMa1995) 1130463..1131413 - 951 WP_010968047.1 ABC transporter permease -
SM_RS30180 (SMa1996) 1131416..1132387 - 972 WP_010968048.1 ABC transporter permease -
SM_RS30185 (SMa1998) 1132404..1133897 - 1494 WP_010968049.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - htpB 1..1354226 1354226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9294.62 Da        Isoelectric Point: 9.8124

>T20641 WP_017264738.1 NC_003037:1128797-1129051 [Sinorhizobium meliloti 1021]
MNSKQRKTLAAVFKDPASGTIEWAAIENLLVAAGADVIEGNGSRVKFEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

>T20641 NC_003037:1128797-1129051 [Sinorhizobium meliloti 1021]
ATGAACAGCAAGCAGAGAAAGACCCTCGCGGCCGTATTCAAGGACCCGGCCTCGGGAACGATTGAATGGGCCGCTATAGA
GAATCTGCTTGTGGCTGCCGGAGCGGACGTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAAGACGGCATCATTG
CGAGCTTTCATCGACCTCATCCGGACAAGGAAGCAAAGCGTTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13236.85 Da        Isoelectric Point: 4.9920

>AT20641 WP_003530441.1 NC_003037:1129048-1129404 [Sinorhizobium meliloti 1021]
MNTMTYNGYHARIEFDAEDEVFFGKIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHFAEARLSA

Download         Length: 357 bp

>AT20641 NC_003037:1129048-1129404 [Sinorhizobium meliloti 1021]
ATGAACACCATGACCTACAACGGGTATCACGCTCGCATCGAATTCGACGCTGAGGACGAAGTGTTTTTCGGCAAGATTGC
AGGTATCTCCGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCGGTCGATGACT
ACCTTGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTCAACCAGTGGGCAGAAGAGGTGCTGGAAGAAGC
CGCCGACCATTTTGCCGAGGCGCGCCTGTCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0G1X1

References