29033

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 257890..258488 Replicon plasmid pSymA
Accession NC_020527
Organism Sinorhizobium meliloti 2011

Toxin (Protein)


Gene name relE Uniprot ID Q930F0
Locus tag SM2011_RS01300 Protein ID WP_010967243.1
Coordinates 258195..258488 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q930F1
Locus tag SM2011_RS01295 Protein ID WP_010967242.1
Coordinates 257890..258198 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM2011_RS01280 253528..254544 + 1017 WP_010967239.1 ABC transporter permease -
SM2011_RS01285 254541..255383 + 843 WP_015445407.1 ABC transporter permease -
SM2011_RS01290 255380..257227 + 1848 WP_015445408.1 ABC transporter ATP-binding protein -
SM2011_RS01295 257890..258198 + 309 WP_010967242.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SM2011_RS01300 258195..258488 + 294 WP_010967243.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
SM2011_RS01305 258677..260011 + 1335 WP_010970069.1 ISNCY-like element ISRm17 family transposase -
SM2011_RS01310 260426..261625 - 1200 WP_041169958.1 NAD-dependent formate dehydrogenase -
SM2011_RS35705 262040..262790 + 751 Protein_260 RepB plasmid partition -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - htpB 1..1352561 1352561
- flank IS/Tn - - 258677..260011 1334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-53)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11278.93 Da        Isoelectric Point: 6.4734

>T29033 WP_010967243.1 NC_020527:258195-258488 [Sinorhizobium meliloti 2011]
MRLVWARYALDDRDTIFSYIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Download         Length: 294 bp

>T29033 NC_020527:258195-258488 [Sinorhizobium meliloti 2011]
ATGAGGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACACCATCTTCAGTTACATCGAAAGGGAGAATCCGAGGGC
GGCGGTCCACGTCGACGAGGAGATCGTCAGCGCGGTACGTCGTCTGCTTGATTTTCCGGAAAGCGGCCGCCCTGGCCGGA
TTGCCGGAACTCGAGAGCTTGTTATCCCTCGGACCCCCTACATTGCAGCCTACATGGTAATGGAGGATAGAATTCGAATT
CTGCGTGTCCTGCACGGCGCCCAGAAGTGGCCCAGCGAGCTCGACGACGGGTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11210.58 Da        Isoelectric Point: 5.6604

>AT29033 WP_010967242.1 NC_020527:257890-258198 [Sinorhizobium meliloti 2011]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAALRKAAAGDR

Download         Length: 309 bp

>AT29033 NC_020527:257890-258198 [Sinorhizobium meliloti 2011]
ATGGCTTCAAATGCACTTGTTCAGACTCGAATCGATGCCGAGGTCAAAGAGCGCGCCACGGCGGTTTTAGAGAACATGGG
TCTGACGGTCTCGGACGCTGTTCGAATCCTGTTAACTCGGACGGCGAATGAGGGCGCCCTGCCGCTGGAACTCTTCAGCC
ACAGCGAGGCGCACGACGCTTGGTTCCGCGCCAAAGTGTTGCGGGCACTCGAGGATACCCGACCCGACGTCGACGATGCC
GACGCCGATGCGCACTTTCGAGAGCGCCGGGCGGCAGCTTTGCGCAAGGCTGCGGCGGGTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q930F0

Antitoxin

Source ID Structure
AlphaFold DB Q930F1

References