20640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 546465..547150 Replicon plasmid pSymA
Accession NC_003037
Organism Sinorhizobium meliloti 1021

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SM_RS27395 Protein ID WP_010967510.1
Coordinates 546465..546884 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SM_RS27400 Protein ID WP_041169972.1
Coordinates 546881..547150 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM_RS27370 (SMa0972) 541929..543182 + 1254 WP_010967506.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
SM_RS27375 (SMa0974) 543237..543596 + 360 WP_010967507.1 hypothetical protein -
SM_RS27380 543639..543796 - 158 Protein_534 helix-turn-helix domain-containing protein -
SM_RS27385 (SMa0976) 543828..544622 - 795 Protein_535 IS256-like element ISRm3 family transposase -
SM_RS27390 (SMa0977) 544943..545944 - 1002 WP_010967509.1 IS30 family transposase -
SM_RS27395 (SMa0981) 546465..546884 - 420 WP_010967510.1 type II toxin-antitoxin system VapC family toxin Toxin
SM_RS27400 546881..547150 - 270 WP_041169972.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SM_RS27405 547259..547462 + 204 Protein_539 hypothetical protein -
SM_RS27410 (SMa0985) 547525..548400 - 876 WP_015445434.1 LysR family transcriptional regulator -
SM_RS27415 549410..549580 + 171 WP_162471696.1 hypothetical protein -
SM_RS31600 (SMa0992) 549895..550287 + 393 WP_010967515.1 hypothetical protein -
SM_RS27425 (SMa5007) 550344..550724 - 381 WP_010967516.1 transcriptional regulator -
SM_RS27430 550742..551053 - 312 WP_003526630.1 type II toxin-antitoxin system HigB family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - htpB 1..1354226 1354226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14785.05 Da        Isoelectric Point: 4.8837

>T20640 WP_010967510.1 NC_003037:c546884-546465 [Sinorhizobium meliloti 1021]
VSRLYMLDTNIVSELARNPQGAVTKRIAEVGPEAVCVSIITAAELRYGCAKKGSPKLLAQIEAILGSMQVLALDVPADAE
YGNIRAELETAGKPIGPNDLFIAAHACVLGAVLVTVNSSEFTRVRDLKVENWLDFTSSG

Download         Length: 420 bp

>T20640 NC_003037:c546884-546465 [Sinorhizobium meliloti 1021]
GTGAGCAGGCTGTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGGTAGGACCGGAGGCAGTCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CACCGAAGCTACTGGCGCAAATCGAGGCCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGTGCCTGCTGATGCCGAA
TATGGCAACATCCGGGCTGAACTGGAGACCGCTGGTAAGCCCATCGGTCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TGTGCTTGGAGCGGTGCTGGTAACGGTCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTTCGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10129.55 Da        Isoelectric Point: 4.4596

>AT20640 WP_041169972.1 NC_003037:c547150-546881 [Sinorhizobium meliloti 1021]
MPQLRHDEPPPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPGKDVDL

Download         Length: 270 bp

>AT20640 NC_003037:c547150-546881 [Sinorhizobium meliloti 1021]
ATGCCCCAACTCCGACACGACGAACCACCACCGCCAAGGGAAGCCAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGATGGAGATCGGCTGATAATCGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTACTGGCAGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCTGACGTTGATGAAACC
CTGCTGCCGGGGAAGGATGTCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References