29034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 546133..546818 Replicon plasmid pSymA
Accession NC_020527
Organism Sinorhizobium meliloti 2011

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SM2011_RS02695 Protein ID WP_010967510.1
Coordinates 546133..546552 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SM2011_RS02700 Protein ID WP_041169972.1
Coordinates 546549..546818 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM2011_RS02675 541597..542850 + 1254 WP_010967506.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
SM2011_RS02680 542905..543264 + 360 WP_010967507.1 hypothetical protein -
SM2011_RS31905 543307..543464 - 158 Protein_533 helix-turn-helix domain-containing protein -
SM2011_RS02685 543496..544290 - 795 Protein_534 IS256-like element ISRm3 family transposase -
SM2011_RS02690 544611..545612 - 1002 WP_010967509.1 IS30 family transposase -
SM2011_RS02695 546133..546552 - 420 WP_010967510.1 type II toxin-antitoxin system VapC family toxin Toxin
SM2011_RS02700 546549..546818 - 270 WP_041169972.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SM2011_RS31910 546927..547130 + 204 Protein_538 hypothetical protein -
SM2011_RS02705 547193..548068 - 876 WP_015445434.1 LysR family transcriptional regulator -
SM2011_RS35745 549078..549248 + 171 WP_162471696.1 hypothetical protein -
SM2011_RS02715 549563..549955 + 393 WP_010967515.1 hypothetical protein -
SM2011_RS02720 550012..550392 - 381 WP_010967516.1 transcriptional regulator -
SM2011_RS02725 550410..550721 - 312 WP_003526630.1 type II toxin-antitoxin system HigB family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - htpB 1..1352561 1352561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14785.05 Da        Isoelectric Point: 4.8837

>T29034 WP_010967510.1 NC_020527:c546552-546133 [Sinorhizobium meliloti 2011]
VSRLYMLDTNIVSELARNPQGAVTKRIAEVGPEAVCVSIITAAELRYGCAKKGSPKLLAQIEAILGSMQVLALDVPADAE
YGNIRAELETAGKPIGPNDLFIAAHACVLGAVLVTVNSSEFTRVRDLKVENWLDFTSSG

Download         Length: 420 bp

>T29034 NC_020527:c546552-546133 [Sinorhizobium meliloti 2011]
GTGAGCAGGCTGTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGGTAGGACCGGAGGCAGTCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CACCGAAGCTACTGGCGCAAATCGAGGCCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGTGCCTGCTGATGCCGAA
TATGGCAACATCCGGGCTGAACTGGAGACCGCTGGTAAGCCCATCGGTCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TGTGCTTGGAGCGGTGCTGGTAACGGTCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTTCGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10129.55 Da        Isoelectric Point: 4.4596

>AT29034 WP_041169972.1 NC_020527:c546818-546549 [Sinorhizobium meliloti 2011]
MPQLRHDEPPPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPGKDVDL

Download         Length: 270 bp

>AT29034 NC_020527:c546818-546549 [Sinorhizobium meliloti 2011]
ATGCCCCAACTCCGACACGACGAACCACCACCGCCAAGGGAAGCCAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGATGGAGATCGGCTGATAATCGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTACTGGCAGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCTGACGTTGATGAAACC
CTGCTGCCGGGGAAGGATGTCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References