77440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 170120..170805 Replicon plasmid psymA
Accession NZ_CP021798
Organism Sinorhizobium meliloti strain USDA1106

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO30_RS18840 Protein ID WP_010967510.1
Coordinates 170386..170805 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDO30_RS18835 Protein ID WP_041169972.1
Coordinates 170120..170389 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO30_RS18795 166217..166528 + 312 WP_003526630.1 type II toxin-antitoxin system HigB family toxin -
CDO30_RS18800 166546..166926 + 381 WP_010967516.1 transcriptional regulator -
CDO30_RS18805 166983..167375 - 393 WP_010967515.1 hypothetical protein -
CDO30_RS34405 167690..167860 - 171 WP_162471696.1 hypothetical protein -
CDO30_RS18825 168870..169745 + 876 WP_015445434.1 LysR family transcriptional regulator -
CDO30_RS18830 169808..170011 - 204 Protein_170 hypothetical protein -
CDO30_RS18835 170120..170389 + 270 WP_041169972.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDO30_RS18840 170386..170805 + 420 WP_010967510.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO30_RS18845 171326..172327 + 1002 WP_010967509.1 IS30 family transposase -
CDO30_RS18850 172648..173442 + 795 Protein_174 IS256-like element ISRm3 family transposase -
CDO30_RS33925 173474..173631 + 158 Protein_175 helix-turn-helix domain-containing protein -
CDO30_RS18855 173674..174033 - 360 WP_010967507.1 hypothetical protein -
CDO30_RS18860 174088..175341 - 1254 WP_010967506.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - htpB 1..1363628 1363628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14785.05 Da        Isoelectric Point: 4.8837

>T77440 WP_010967510.1 NZ_CP021798:170386-170805 [Sinorhizobium meliloti]
VSRLYMLDTNIVSELARNPQGAVTKRIAEVGPEAVCVSIITAAELRYGCAKKGSPKLLAQIEAILGSMQVLALDVPADAE
YGNIRAELETAGKPIGPNDLFIAAHACVLGAVLVTVNSSEFTRVRDLKVENWLDFTSSG

Download         Length: 420 bp

>T77440 NZ_CP021798:170386-170805 [Sinorhizobium meliloti]
GTGAGCAGGCTGTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGGTAGGACCGGAGGCAGTCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CACCGAAGCTACTGGCGCAAATCGAGGCCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGTGCCTGCTGATGCCGAA
TATGGCAACATCCGGGCTGAACTGGAGACCGCTGGTAAGCCCATCGGTCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TGTGCTTGGAGCGGTGCTGGTAACGGTCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTTCGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10129.55 Da        Isoelectric Point: 4.4596

>AT77440 WP_041169972.1 NZ_CP021798:170120-170389 [Sinorhizobium meliloti]
MPQLRHDEPPPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPGKDVDL

Download         Length: 270 bp

>AT77440 NZ_CP021798:170120-170389 [Sinorhizobium meliloti]
ATGCCCCAACTCCGACACGACGAACCACCACCGCCAAGGGAAGCCAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGATGGAGATCGGCTGATAATCGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTACTGGCAGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCTGACGTTGATGAAACC
CTGCTGCCGGGGAAGGATGTCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References