77441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 465435..466033 Replicon plasmid psymA
Accession NZ_CP021798
Organism Sinorhizobium meliloti strain USDA1106

Toxin (Protein)


Gene name relE Uniprot ID Q930F0
Locus tag CDO30_RS20510 Protein ID WP_010967243.1
Coordinates 465435..465728 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q930F1
Locus tag CDO30_RS20515 Protein ID WP_010967242.1
Coordinates 465725..466033 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO30_RS20495 460627..461826 + 1200 WP_041169958.1 NAD-dependent formate dehydrogenase -
CDO30_RS20500 462241..463575 - 1335 WP_010970069.1 ISNCY-like element ISRm17 family transposase -
CDO30_RS20505 463912..465246 - 1335 WP_010970069.1 ISNCY-like element ISRm17 family transposase -
CDO30_RS20510 465435..465728 - 294 WP_010967243.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CDO30_RS20515 465725..466033 - 309 WP_010967242.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CDO30_RS20520 466696..468543 - 1848 WP_015445408.1 ABC transporter ATP-binding protein -
CDO30_RS20525 468540..469382 - 843 WP_015445407.1 ABC transporter permease -
CDO30_RS20530 469379..470395 - 1017 WP_010967239.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - htpB 1..1363628 1363628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-53)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11278.93 Da        Isoelectric Point: 6.4734

>T77441 WP_010967243.1 NZ_CP021798:c465728-465435 [Sinorhizobium meliloti]
MRLVWARYALDDRDTIFSYIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Download         Length: 294 bp

>T77441 NZ_CP021798:c465728-465435 [Sinorhizobium meliloti]
ATGAGGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACACCATCTTCAGTTACATCGAAAGGGAGAATCCGAGGGC
GGCGGTCCACGTCGACGAGGAGATCGTCAGCGCGGTACGTCGTCTGCTTGATTTTCCGGAAAGCGGCCGCCCTGGCCGGA
TTGCCGGAACTCGAGAGCTTGTTATCCCTCGGACCCCCTACATTGCAGCCTACATGGTAATGGAGGATAGAATTCGAATT
CTGCGTGTCCTGCACGGCGCCCAGAAGTGGCCCAGCGAGCTCGACGACGGGTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11210.58 Da        Isoelectric Point: 5.6604

>AT77441 WP_010967242.1 NZ_CP021798:c466033-465725 [Sinorhizobium meliloti]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAALRKAAAGDR

Download         Length: 309 bp

>AT77441 NZ_CP021798:c466033-465725 [Sinorhizobium meliloti]
ATGGCTTCAAATGCACTTGTTCAGACTCGAATCGATGCCGAGGTCAAAGAGCGCGCCACGGCGGTTTTAGAGAACATGGG
TCTGACGGTCTCGGACGCTGTTCGAATCCTGTTAACTCGGACGGCGAATGAGGGCGCCCTGCCGCTGGAACTCTTCAGCC
ACAGCGAGGCGCACGACGCTTGGTTCCGCGCCAAAGTGTTGCGGGCACTCGAGGATACCCGACCCGACGTCGACGATGCC
GACGCCGATGCGCACTTTCGAGAGCGCCGGGCGGCAGCTTTGCGCAAGGCTGCGGCGGGTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q930F0

Antitoxin

Source ID Structure
AlphaFold DB Q930F1

References