Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VIII Classification (family/domain) SdsR-RyeA/-
Location 1323258..1323492 Replicon chromosome
Accession NZ_CP037923
Organism Shigella flexneri 5a str. M90T

Toxin (RNA)


Gene name SdsR
Locus tag -
Coordinates 1323388..1323491 (+)

Antitoxin (RNA)


Gene name RyeA
Locus tag -
Coordinates 1323258..1323492 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN05_RS06760 (EKN05_006775) 1319813..1320475 - 663 WP_000944267.1 exodeoxyribonuclease X -
EKN05_RS06765 (EKN05_006780) 1320499..1321155 - 657 Protein_1295 carbon-nitrogen hydrolase family protein YobB -
EKN05_RS06770 (EKN05_006785) 1321257..1321487 - 231 WP_000916757.1 DNA polymerase III subunit theta -
EKN05_RS06775 (EKN05_006790) 1321626..1322000 + 375 WP_000168747.1 CopC domain-containing protein YobA -
EKN05_RS06780 (EKN05_006795) 1322004..1322876 + 873 WP_000879271.1 copper homeostasis membrane protein CopD -
EKN05_RS06785 (EKN05_006800) 1322889..1323230 + 342 WP_000976476.1 YebY family protein -
- 1323258..1323492 - 235 - - Antitoxin
- 1323388..1323491 + 104 - - Toxin
EKN05_RS06790 (EKN05_006805) 1323623..1324699 - 1077 WP_001189100.1 phage integrase Arm DNA-binding domain-containing protein -
EKN05_RS06795 (EKN05_006810) 1324665..1324946 - 282 WP_094096572.1 excisionase -
EKN05_RS06805 (EKN05_006820) 1326320..1326508 - 189 WP_000276807.1 DUF1187 family protein -
EKN05_RS06810 (EKN05_006825) 1326559..1327656 - 1098 WP_001173296.1 AAA family ATPase -
EKN05_RS06815 (EKN05_006830) 1327686..1327958 - 273 WP_001277358.1 host-nuclease inhibitor Gam family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1317756..1337986 20230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Sequences

Toxin        


Download         Length: 104 bp

>T120364 NZ_CP037923:1323388-1323491 [Shigella flexneri 5a str. M90T]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 235 bp

>AT120364 NZ_CP037923:c1323492-1323258 [Shigella flexneri 5a str. M90T]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

Download structure file

Antitoxin

Download structure file

References