Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) /-
Location 1533153..1533455 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name holin Uniprot ID A0A2S6DEP6
Locus tag MW_RS07425 Protein ID WP_000339141.1
Coordinates 1533153..1533455 (-) Length 101 a.a.

Antitoxin (RNA)


Gene name -
Locus tag -
Coordinates - ()

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS07405 (MW1377) 1528947..1529132 - 186 WP_000470336.1 hypothetical protein -
MW_RS07410 (MW1378) 1529381..1530364 - 984 WP_024937002.1 Panton-Valentine bi-component leukocidin subunit F -
MW_RS07415 (MW1379) 1530360..1531298 - 939 WP_000239545.1 Panton-Valentine bi-component leukocidin subunit S -
MW_RS07420 (MW1380) 1531688..1533142 - 1455 WP_000909207.1 N-acetylmuramoyl-L-alanine amidase -
MW_RS07425 (MW1381) 1533153..1533455 - 303 WP_000339141.1 phage holin Toxin
MW_RS07430 (MW1382) 1533591..1533890 - 300 WP_000466784.1 DUF2951 domain-containing protein -
MW_RS07435 (MW1383) 1533936..1534100 - 165 WP_000916020.1 XkdX family protein -
MW_RS07440 (MW1384) 1534093..1534482 - 390 WP_001166599.1 DUF2977 domain-containing protein -
MW_RS07445 (MW1385) 1534482..1535948 - 1467 WP_000067140.1 BppU family phage baseplate upper protein -
MW_RS07450 (MW1386) 1535948..1537858 - 1911 WP_000429551.1 minor structural protein -
MW_RS07455 (MW1387) 1537874..1538164 - 291 WP_000179858.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukF-PV / lukS-PV 1526005..1592556 66551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Holin

(1-71)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11174.92 Da        Isoelectric Point: 9.6413

>T10156 WP_000339141.1 NC_003923:c1533455-1533153 [Staphylococcus aureus subsp. aureus MW2]
MDAKVITRYIVLILALVNQFLANKGISPIPVDDETISSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Download         Length: 303 bp

>T10156 NC_003923:c1533455-1533153 [Staphylococcus aureus subsp. aureus MW2]
ATGGATGCAAAAGTAATAACAAGATACATCGTATTGATCTTAGCATTAGTAAATCAATTCTTAGCGAACAAAGGTATTAG
CCCGATTCCAGTAGACGATGAGACTATATCATCAATAATACTTACTGTTGTTGCTTTATATACTACGTATAAAGACAATC
CAACATCTCAAGAAGGTAAATGGGCAAATCAAAAGCTAAAGAAATATAAAGCTGAAAACAAGTATAGAAAAGCAACAGGG
CAAGCGCCAATTAAAGAAGTAATGACACCTACGAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin


Download         Length: 1 bp

>AT10156 NC_019359:3970-4272 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAGGCTCGTATTCAACAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACCATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6DEP6

Antitoxin

Download structure file

References

(1) Gul Habib et al. (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins 10(11):473. [PubMed:30441856] experimental


experimental experimental literature