Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1557510..1557924 Replicon chromosome
Accession NZ_CP019574
Organism Staphylococcus aureus strain USA400-0051

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SAU400_RS07800 Protein ID WP_001826875.1
Coordinates 1557673..1557924 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SAU400_RS14840 Protein ID WP_000028424.1
Coordinates 1557510..1557683 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAU400_RS07750 1552511..1552609 + 99 WP_001801650.1 hypothetical protein -
SAU400_RS07755 1552718..1555165 - 2448 WP_000884870.1 virulence-associated E family protein -
SAU400_RS07765 1555453..1555653 - 201 WP_000265252.1 DUF1514 family protein -
SAU400_RS07770 1555721..1555873 - 153 WP_000237867.1 transcriptional activator RinB -
SAU400_RS07775 1555876..1556076 - 201 WP_001125015.1 hypothetical protein -
SAU400_RS07780 1556051..1556239 - 189 WP_000195817.1 DUF1381 domain-containing protein -
SAU400_RS07785 1556236..1556481 - 246 WP_001282074.1 hypothetical protein -
SAU400_RS07790 1556518..1557051 - 534 WP_001061841.1 dUTPase -
SAU400_RS14835 1557066..1557227 - 162 WP_000889679.1 hypothetical protein -
SAU400_RS07795 1557228..1557509 - 282 WP_000454993.1 hypothetical protein -
SAU400_RS14840 1557510..1557683 - 174 WP_000028424.1 hypothetical protein Antitoxin
SAU400_RS07800 1557673..1557924 - 252 WP_001826875.1 DUF1024 family protein Toxin
SAU400_RS07805 1557939..1558181 - 243 WP_000132192.1 hypothetical protein -
SAU400_RS07810 1558196..1558396 - 201 WP_000235322.1 hypothetical protein -
SAU400_RS07815 1558399..1558656 - 258 WP_000022728.1 DUF3310 domain-containing protein -
SAU400_RS07820 1558656..1559057 - 402 WP_000113974.1 PVL family protein -
SAU400_RS07825 1559057..1559242 - 186 WP_001164629.1 DUF3113 family protein -
SAU400_RS07830 1559255..1561208 - 1954 Protein_1457 DNA polymerase -
SAU400_RS07835 1561276..1561833 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukF-PV / lukS-PV / lukS-PV 1523368..1582098 58730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9489.40 Da        Isoelectric Point: 3.9476

>T72683 WP_001826875.1 NZ_CP019574:c1557924-1557673 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T72683 NZ_CP019574:c1557924-1557673 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAATAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT72683 WP_000028424.1 NZ_CP019574:c1557683-1557510 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT72683 NZ_CP019574:c1557683-1557510 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References