20731

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1571120..1571917 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name - Uniprot ID A0A6K0KKW3
Locus tag MW_RS07695 Protein ID WP_000525002.1
Coordinates 1571456..1571917 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MW_RS07690 Protein ID WP_001260485.1
Coordinates 1571120..1571443 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS07640 (MW1426) 1566856..1567413 - 558 WP_000645048.1 DUF2815 family protein -
MW_RS07645 (MW1427) 1567439..1568605 - 1167 WP_000762552.1 DUF2800 domain-containing protein -
MW_RS07650 (MW1428) 1568602..1568964 - 363 WP_000985979.1 hypothetical protein -
MW_RS07655 (MW1429) 1568979..1569302 - 324 WP_000174994.1 hypothetical protein -
MW_RS07660 (MW1430) 1569381..1569542 - 162 WP_001285963.1 DUF1270 family protein -
MW_RS07665 (MW1431) 1569555..1569818 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
MW_RS07670 (MW1432) 1569843..1570058 - 216 WP_001036302.1 hypothetical protein -
MW_RS07675 (MW1433) 1570113..1570478 + 366 WP_001128433.1 hypothetical protein -
MW_RS07680 (MW1434) 1570447..1570692 - 246 WP_001025401.1 DUF2829 domain-containing protein -
MW_RS07685 (MW1435) 1570708..1570956 - 249 WP_000272860.1 helix-turn-helix domain-containing protein -
MW_RS07690 (MW1436) 1571120..1571443 + 324 WP_001260485.1 helix-turn-helix domain-containing protein Antitoxin
MW_RS07695 (MW1437) 1571456..1571917 + 462 WP_000525002.1 hypothetical protein Toxin
MW_RS07700 (MW1438) 1571935..1572369 + 435 WP_000755718.1 hypothetical protein -
MW_RS07705 (MW1439) 1572398..1572793 + 396 WP_000449653.1 hypothetical protein -
MW_RS07710 (MW1441) 1572992..1573615 - 624 WP_001166482.1 hypothetical protein -
MW_RS07715 (MW1442) 1573725..1574930 + 1206 WP_000264191.1 site-specific integrase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukF-PV / lukS-PV 1526005..1592556 66551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-65)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 17943.33 Da        Isoelectric Point: 5.0698

>T20731 WP_000525002.1 NC_003923:1571456-1571917 [Staphylococcus aureus subsp. aureus MW2]
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T20731 NC_003923:1571456-1571917 [Staphylococcus aureus subsp. aureus MW2]
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12439.16 Da        Isoelectric Point: 9.3811

>AT20731 WP_001260485.1 NC_003923:1571120-1571443 [Staphylococcus aureus subsp. aureus MW2]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT20731 NC_003923:1571120-1571443 [Staphylococcus aureus subsp. aureus MW2]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6K0KKW3


Antitoxin

Source ID Structure

References