Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1565540..1566337 Replicon chromosome
Accession NZ_CP019574
Organism Staphylococcus aureus strain USA400-0051

Toxin (Protein)


Gene name - Uniprot ID A0A6K0KKW3
Locus tag SAU400_RS07890 Protein ID WP_000525002.1
Coordinates 1565876..1566337 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag SAU400_RS07885 Protein ID WP_001260485.1
Coordinates 1565540..1565863 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAU400_RS07835 1561276..1561833 - 558 WP_000645048.1 DUF2815 family protein -
SAU400_RS07840 1561859..1563025 - 1167 WP_000762552.1 DUF2800 domain-containing protein -
SAU400_RS07845 1563022..1563384 - 363 WP_000985979.1 hypothetical protein -
SAU400_RS07850 1563399..1563722 - 324 WP_000174994.1 hypothetical protein -
SAU400_RS07855 1563801..1563962 - 162 WP_001285963.1 DUF1270 family protein -
SAU400_RS07860 1563975..1564238 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
SAU400_RS07865 1564263..1564478 - 216 WP_001036302.1 hypothetical protein -
SAU400_RS07870 1564533..1564898 + 366 WP_001128433.1 hypothetical protein -
SAU400_RS07875 1564867..1565112 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SAU400_RS07880 1565128..1565376 - 249 WP_000272860.1 helix-turn-helix domain-containing protein -
SAU400_RS07885 1565540..1565863 + 324 WP_001260485.1 helix-turn-helix domain-containing protein Antitoxin
SAU400_RS07890 1565876..1566337 + 462 WP_000525002.1 hypothetical protein Toxin
SAU400_RS07895 1566355..1566789 + 435 WP_000755718.1 hypothetical protein -
SAU400_RS07900 1566818..1567213 + 396 WP_000449653.1 hypothetical protein -
SAU400_RS14845 1567411..1567638 - 228 WP_000471064.1 hypothetical protein -
SAU400_RS07910 1568143..1569346 + 1204 Protein_1473 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukF-PV / lukS-PV / lukS-PV 1523368..1582098 58730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17943.33 Da        Isoelectric Point: 5.0698

>T72687 WP_000525002.1 NZ_CP019574:1565876-1566337 [Staphylococcus aureus]
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T72687 NZ_CP019574:1565876-1566337 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12439.16 Da        Isoelectric Point: 9.3811

>AT72687 WP_001260485.1 NZ_CP019574:1565540-1565863 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT72687 NZ_CP019574:1565540-1565863 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6K0KKW3

Antitoxin

Source ID Structure

References