Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1565540..1566337 | Replicon | chromosome |
| Accession | NZ_CP019574 | ||
| Organism | Staphylococcus aureus strain USA400-0051 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A6K0KKW3 |
| Locus tag | SAU400_RS07890 | Protein ID | WP_000525002.1 |
| Coordinates | 1565876..1566337 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | SAU400_RS07885 | Protein ID | WP_001260485.1 |
| Coordinates | 1565540..1565863 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAU400_RS07835 | 1561276..1561833 | - | 558 | WP_000645048.1 | DUF2815 family protein | - |
| SAU400_RS07840 | 1561859..1563025 | - | 1167 | WP_000762552.1 | DUF2800 domain-containing protein | - |
| SAU400_RS07845 | 1563022..1563384 | - | 363 | WP_000985979.1 | hypothetical protein | - |
| SAU400_RS07850 | 1563399..1563722 | - | 324 | WP_000174994.1 | hypothetical protein | - |
| SAU400_RS07855 | 1563801..1563962 | - | 162 | WP_001285963.1 | DUF1270 family protein | - |
| SAU400_RS07860 | 1563975..1564238 | - | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| SAU400_RS07865 | 1564263..1564478 | - | 216 | WP_001036302.1 | hypothetical protein | - |
| SAU400_RS07870 | 1564533..1564898 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| SAU400_RS07875 | 1564867..1565112 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| SAU400_RS07880 | 1565128..1565376 | - | 249 | WP_000272860.1 | helix-turn-helix domain-containing protein | - |
| SAU400_RS07885 | 1565540..1565863 | + | 324 | WP_001260485.1 | helix-turn-helix domain-containing protein | Antitoxin |
| SAU400_RS07890 | 1565876..1566337 | + | 462 | WP_000525002.1 | hypothetical protein | Toxin |
| SAU400_RS07895 | 1566355..1566789 | + | 435 | WP_000755718.1 | hypothetical protein | - |
| SAU400_RS07900 | 1566818..1567213 | + | 396 | WP_000449653.1 | hypothetical protein | - |
| SAU400_RS14845 | 1567411..1567638 | - | 228 | WP_000471064.1 | hypothetical protein | - |
| SAU400_RS07910 | 1568143..1569346 | + | 1204 | Protein_1473 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | lukF-PV / lukS-PV / lukS-PV | 1523368..1582098 | 58730 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 17943.33 Da Isoelectric Point: 5.0698
>T72687 WP_000525002.1 NZ_CP019574:1565876-1566337 [Staphylococcus aureus]
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T72687 NZ_CP019574:1565876-1566337 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT72687 WP_001260485.1 NZ_CP019574:1565540-1565863 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT72687 NZ_CP019574:1565540-1565863 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|