Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1563091..1563505 | Replicon | chromosome |
| Accession | NC_003923 | ||
| Organism | Staphylococcus aureus subsp. aureus MW2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MW_RS07605 | Protein ID | WP_001826875.1 |
| Coordinates | 1563254..1563505 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MW_RS15240 | Protein ID | WP_000028424.1 |
| Coordinates | 1563091..1563264 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MW_RS07560 | 1558092..1558190 | + | 99 | WP_001801650.1 | hypothetical protein | - |
| MW_RS07565 (MW1408) | 1558299..1560746 | - | 2448 | WP_000884870.1 | virulence-associated E family protein | - |
| MW_RS07570 (MW1410) | 1561034..1561234 | - | 201 | WP_000265252.1 | DUF1514 family protein | - |
| MW_RS07575 (MW1411) | 1561302..1561454 | - | 153 | WP_000237867.1 | transcriptional activator RinB | - |
| MW_RS07580 (MW1412) | 1561457..1561657 | - | 201 | WP_001125015.1 | hypothetical protein | - |
| MW_RS07585 (MW1413) | 1561632..1561820 | - | 189 | WP_000195817.1 | DUF1381 domain-containing protein | - |
| MW_RS07590 (MW1414) | 1561817..1562062 | - | 246 | WP_001282074.1 | hypothetical protein | - |
| MW_RS07595 (MW1415) | 1562099..1562632 | - | 534 | WP_001061841.1 | dUTPase | - |
| MW_RS15235 | 1562647..1562808 | - | 162 | WP_000889679.1 | hypothetical protein | - |
| MW_RS07600 (MW1417) | 1562809..1563090 | - | 282 | WP_000454993.1 | hypothetical protein | - |
| MW_RS15240 | 1563091..1563264 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| MW_RS07605 (MW1419) | 1563254..1563505 | - | 252 | WP_001826875.1 | DUF1024 family protein | Toxin |
| MW_RS07610 (MW1420) | 1563520..1563762 | - | 243 | WP_000132192.1 | hypothetical protein | - |
| MW_RS07615 (MW1421) | 1563777..1563977 | - | 201 | WP_000235322.1 | hypothetical protein | - |
| MW_RS07620 (MW1422) | 1563980..1564237 | - | 258 | WP_000022728.1 | DUF3310 domain-containing protein | - |
| MW_RS07625 (MW1423) | 1564237..1564638 | - | 402 | WP_000113974.1 | PVL family protein | - |
| MW_RS07630 (MW1424) | 1564638..1564823 | - | 186 | WP_001164629.1 | DUF3113 family protein | - |
| MW_RS07635 (MW1425) | 1564836..1566788 | - | 1953 | WP_001801657.1 | DNA polymerase | - |
| MW_RS07640 (MW1426) | 1566856..1567413 | - | 558 | WP_000645048.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | lukF-PV / lukS-PV | 1526005..1592556 | 66551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9489.40 Da Isoelectric Point: 3.9476
>T10153 WP_001826875.1 NC_003923:c1563505-1563254 [Staphylococcus aureus subsp. aureus MW2]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T10153 NC_003923:c1563505-1563254 [Staphylococcus aureus subsp. aureus MW2]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAATAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAATAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT10153 WP_000028424.1 NC_003923:c1563264-1563091 [Staphylococcus aureus subsp. aureus MW2]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT10153 NC_003923:c1563264-1563091 [Staphylococcus aureus subsp. aureus MW2]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Gul Habib et al. (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins 10(11):473. [PubMed:30441856]