93149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 559588..560002 Replicon chromosome
Accession NZ_CP026073
Organism Staphylococcus aureus strain FDAARGOS_42

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RL00_RS03225 Protein ID WP_001826875.1
Coordinates 559588..559839 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RL00_RS14670 Protein ID WP_000028424.1
Coordinates 559829..560002 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL00_RS03190 555680..556237 + 558 WP_000645048.1 DUF2815 family protein -
RL00_RS03195 556305..558257 + 1953 WP_001801657.1 DNA polymerase -
RL00_RS03200 558270..558455 + 186 WP_001164629.1 DUF3113 family protein -
RL00_RS03205 558455..558856 + 402 WP_000113974.1 PVL family protein -
RL00_RS03210 558856..559113 + 258 WP_000022728.1 DUF3310 domain-containing protein -
RL00_RS03215 559116..559316 + 201 WP_000235322.1 hypothetical protein -
RL00_RS03220 559331..559573 + 243 WP_000132192.1 hypothetical protein -
RL00_RS03225 559588..559839 + 252 WP_001826875.1 DUF1024 family protein Toxin
RL00_RS14670 559829..560002 + 174 WP_000028424.1 hypothetical protein Antitoxin
RL00_RS03230 560003..560284 + 282 WP_000454993.1 hypothetical protein -
RL00_RS14675 560285..560446 + 162 WP_000889679.1 hypothetical protein -
RL00_RS03235 560461..560994 + 534 WP_001061841.1 dUTPase -
RL00_RS03240 561031..561276 + 246 WP_001282074.1 hypothetical protein -
RL00_RS03245 561273..561461 + 189 WP_000195817.1 DUF1381 domain-containing protein -
RL00_RS03250 561436..561636 + 201 WP_001125015.1 hypothetical protein -
RL00_RS03255 561639..561791 + 153 WP_000237867.1 transcriptional activator RinB -
RL00_RS03260 561859..562059 + 201 WP_000265252.1 DUF1514 family protein -
RL00_RS03270 562347..564794 + 2448 WP_000884870.1 virulence-associated E family protein -
RL00_RS03275 564903..565001 - 99 WP_001801650.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukS-PV / lukF-PV 545174..593712 48538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9489.40 Da        Isoelectric Point: 3.9476

>T93149 WP_001826875.1 NZ_CP026073:559588-559839 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T93149 NZ_CP026073:559588-559839 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAATAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT93149 WP_000028424.1 NZ_CP026073:559829-560002 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT93149 NZ_CP026073:559829-560002 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References