Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) TMCS/-
Location 1570113..1570956 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name MW1434 Uniprot ID A0A4P7P609
Locus tag MW_RS07680 Protein ID WP_001025401.1
Coordinates 1570447..1570692 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag MW_RS07675
Coordinates 1570113..1570478 (+)

Regulator (Protein)


Gene name MW1435 Uniprot ID -
Locus tag MW_RS07685 Protein ID WP_000272860.1
Coordinates 1570708..1570956 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS07640 (MW1426) 1566856..1567413 - 558 WP_000645048.1 DUF2815 family protein -
MW_RS07645 (MW1427) 1567439..1568605 - 1167 WP_000762552.1 DUF2800 domain-containing protein -
MW_RS07650 (MW1428) 1568602..1568964 - 363 WP_000985979.1 hypothetical protein -
MW_RS07655 (MW1429) 1568979..1569302 - 324 WP_000174994.1 hypothetical protein -
MW_RS07660 (MW1430) 1569381..1569542 - 162 WP_001285963.1 DUF1270 family protein -
MW_RS07665 (MW1431) 1569555..1569818 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
MW_RS07670 (MW1432) 1569843..1570058 - 216 WP_001036302.1 hypothetical protein -
MW_RS07675 (MW1433) 1570113..1570478 + 366 WP_001128433.1 hypothetical protein Antitoxin
MW_RS07680 (MW1434) 1570447..1570692 - 246 WP_001025401.1 DUF2829 domain-containing protein Toxin
MW_RS07685 (MW1435) 1570708..1570956 - 249 WP_000272860.1 helix-turn-helix domain-containing protein Regulator
MW_RS07690 (MW1436) 1571120..1571443 + 324 WP_001260485.1 helix-turn-helix domain-containing protein -
MW_RS07695 (MW1437) 1571456..1571917 + 462 WP_000525002.1 hypothetical protein -
MW_RS07700 (MW1438) 1571935..1572369 + 435 WP_000755718.1 hypothetical protein -
MW_RS07705 (MW1439) 1572398..1572793 + 396 WP_000449653.1 hypothetical protein -
MW_RS07710 (MW1441) 1572992..1573615 - 624 WP_001166482.1 hypothetical protein -
MW_RS07715 (MW1442) 1573725..1574930 + 1206 WP_000264191.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukF-PV / lukS-PV 1526005..1592556 66551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF2829

(2-69)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9468.72 Da        Isoelectric Point: 5.7783

>T10107 WP_001025401.1 NC_003923:c1570692-1570447 [Staphylococcus aureus subsp. aureus MW2]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Download         Length: 246 bp

>T10107 NC_003923:c1570692-1570447 [Staphylococcus aureus subsp. aureus MW2]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 366 bp

>AT10107 NC_003923:1570113-1570478 [Staphylococcus aureus subsp. aureus MW2]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Regulator


Download         Length: 83 a.a.        Molecular weight: 9373.95 Da        Isoelectric Point: 10.0384

>RE10107 WP_000272860.1 NC_003923:c1570956-1570708 [Staphylococcus aureus subsp. aureus MW2]
MYEFNVKRMKAERIAKGISISDMAKKLGMTPGTYSKKENGHIRINVDDLAKVIEVLELPQDKCGIFFTYRVSKMSTKQEQ
TS

Download         Length: 249 bp

>RE10107 NC_003923:c1570956-1570708 [Staphylococcus aureus subsp. aureus MW2]
ATGTATGAGTTCAATGTCAAAAGAATGAAAGCTGAGCGCATTGCTAAAGGCATTTCGATTTCTGATATGGCAAAAAAATT
AGGAATGACACCAGGAACTTATTCAAAAAAAGAAAACGGACATATTAGAATTAATGTTGACGATTTAGCAAAAGTAATTG
AAGTGTTAGAATTACCACAAGATAAGTGCGGTATTTTTTTTACTTACAGAGTTTCCAAAATGTCAACAAAACAAGAACAA
ACATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7P609

Antitoxin

Download structure file

References

(1) Gul Habib et al. (2020) A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus. International Journal of Medical Microbiology : IJMM 310(2):151400. [PubMed:32001143] experimental


experimental experimental literature