Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1570113..1570956 | Replicon | chromosome |
| Accession | NC_003923 | ||
| Organism | Staphylococcus aureus subsp. aureus MW2 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | MW_RS07680 | Protein ID | WP_001025401.1 |
| Coordinates | 1570447..1570692 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | MW_RS07675 | ||
| Coordinates | 1570113..1570478 (+) |
Regulator (Protein)
| Gene name | MW1435 | Uniprot ID | - |
| Locus tag | MW_RS07685 | Protein ID | WP_000272860.1 |
| Coordinates | 1570708..1570956 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MW_RS07640 (MW1426) | 1566856..1567413 | - | 558 | WP_000645048.1 | DUF2815 family protein | - |
| MW_RS07645 (MW1427) | 1567439..1568605 | - | 1167 | WP_000762552.1 | DUF2800 domain-containing protein | - |
| MW_RS07650 (MW1428) | 1568602..1568964 | - | 363 | WP_000985979.1 | hypothetical protein | - |
| MW_RS07655 (MW1429) | 1568979..1569302 | - | 324 | WP_000174994.1 | hypothetical protein | - |
| MW_RS07660 (MW1430) | 1569381..1569542 | - | 162 | WP_001285963.1 | DUF1270 family protein | - |
| MW_RS07665 (MW1431) | 1569555..1569818 | - | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| MW_RS07670 (MW1432) | 1569843..1570058 | - | 216 | WP_001036302.1 | hypothetical protein | - |
| MW_RS07675 (MW1433) | 1570113..1570478 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| MW_RS07680 (MW1434) | 1570447..1570692 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| MW_RS07685 (MW1435) | 1570708..1570956 | - | 249 | WP_000272860.1 | helix-turn-helix domain-containing protein | Regulator |
| MW_RS07690 (MW1436) | 1571120..1571443 | + | 324 | WP_001260485.1 | helix-turn-helix domain-containing protein | - |
| MW_RS07695 (MW1437) | 1571456..1571917 | + | 462 | WP_000525002.1 | hypothetical protein | - |
| MW_RS07700 (MW1438) | 1571935..1572369 | + | 435 | WP_000755718.1 | hypothetical protein | - |
| MW_RS07705 (MW1439) | 1572398..1572793 | + | 396 | WP_000449653.1 | hypothetical protein | - |
| MW_RS07710 (MW1441) | 1572992..1573615 | - | 624 | WP_001166482.1 | hypothetical protein | - |
| MW_RS07715 (MW1442) | 1573725..1574930 | + | 1206 | WP_000264191.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | lukF-PV / lukS-PV | 1526005..1592556 | 66551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T10107 WP_001025401.1 NC_003923:c1570692-1570447 [Staphylococcus aureus subsp. aureus MW2]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T10107 NC_003923:c1570692-1570447 [Staphylococcus aureus subsp. aureus MW2]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG
Antitoxin
Download Length: 366 bp
>AT10107 NC_003923:1570113-1570478 [Staphylococcus aureus subsp. aureus MW2]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Regulator
Download Length: 83 a.a. Molecular weight: 9373.95 Da Isoelectric Point: 10.0384
>RE10107 WP_000272860.1 NC_003923:c1570956-1570708 [Staphylococcus aureus subsp. aureus MW2]
MYEFNVKRMKAERIAKGISISDMAKKLGMTPGTYSKKENGHIRINVDDLAKVIEVLELPQDKCGIFFTYRVSKMSTKQEQ
TS
MYEFNVKRMKAERIAKGISISDMAKKLGMTPGTYSKKENGHIRINVDDLAKVIEVLELPQDKCGIFFTYRVSKMSTKQEQ
TS
Download Length: 249 bp
>RE10107 NC_003923:c1570956-1570708 [Staphylococcus aureus subsp. aureus MW2]
ATGTATGAGTTCAATGTCAAAAGAATGAAAGCTGAGCGCATTGCTAAAGGCATTTCGATTTCTGATATGGCAAAAAAATT
AGGAATGACACCAGGAACTTATTCAAAAAAAGAAAACGGACATATTAGAATTAATGTTGACGATTTAGCAAAAGTAATTG
AAGTGTTAGAATTACCACAAGATAAGTGCGGTATTTTTTTTACTTACAGAGTTTCCAAAATGTCAACAAAACAAGAACAA
ACATCTTAA
ATGTATGAGTTCAATGTCAAAAGAATGAAAGCTGAGCGCATTGCTAAAGGCATTTCGATTTCTGATATGGCAAAAAAATT
AGGAATGACACCAGGAACTTATTCAAAAAAAGAAAACGGACATATTAGAATTAATGTTGACGATTTAGCAAAAGTAATTG
AAGTGTTAGAATTACCACAAGATAAGTGCGGTATTTTTTTTACTTACAGAGTTTCCAAAATGTCAACAAAACAAGAACAA
ACATCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Gul Habib et al. (2020) A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus. International Journal of Medical Microbiology : IJMM 310(2):151400. [PubMed:32001143]