Detailed information of TA system TA072684

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1564533..1565112
• Replicon: chromosome
• Accession: NZ_CP019574
• Organism: Staphylococcus aureus strain USA400-0051

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAU400_RS07875
• Protein ID: WP_001025401.1
• Coordinates: 1564867..1565112 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1564533..1564898 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAU400_RS07835	1561276..1561833	-	558	WP_000645048.1	DUF2815 family protein	-
SAU400_RS07840	1561859..1563025	-	1167	WP_000762552.1	DUF2800 domain-containing protein	-
SAU400_RS07845	1563022..1563384	-	363	WP_000985979.1	hypothetical protein	-
SAU400_RS07850	1563399..1563722	-	324	WP_000174994.1	hypothetical protein	-
SAU400_RS07855	1563801..1563962	-	162	WP_001285963.1	DUF1270 family protein	-
SAU400_RS07860	1563975..1564238	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
SAU400_RS07865	1564263..1564478	-	216	WP_001036302.1	hypothetical protein	-
SAU400_RS07870	1564533..1564898	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAU400_RS07875	1564867..1565112	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAU400_RS07880	1565128..1565376	-	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
SAU400_RS07885	1565540..1565863	+	324	WP_001260485.1	helix-turn-helix domain-containing protein	-
SAU400_RS07890	1565876..1566337	+	462	WP_000525002.1	hypothetical protein	-
SAU400_RS07895	1566355..1566789	+	435	WP_000755718.1	hypothetical protein	-
SAU400_RS07900	1566818..1567213	+	396	WP_000449653.1	hypothetical protein	-
SAU400_RS14845	1567411..1567638	-	228	WP_000471064.1	hypothetical protein	-
SAU400_RS07910	1568143..1569346	+	1204	Protein_1473	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003923 Staphylococcus aureus subsp. aureus MW2 Prophage TA000611, TA010107, TA010153, TA010156, TA020731 1526005..1592556 0.003	inside	Prophage	-	lukF-PV / lukS-PV / lukS-PV	1523368..1582098	58730

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T72684 WP_001025401.1 NZ_CP019574:c1565112-1564867 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T72684 NZ_CP019574:c1565112-1564867 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT72684 NZ_CP019574:1564533-1564898 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin