Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 551176..551973 | Replicon | chromosome |
| Accession | NZ_CP026073 | ||
| Organism | Staphylococcus aureus strain FDAARGOS_42 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A6K0KKW3 |
| Locus tag | RL00_RS03135 | Protein ID | WP_000525002.1 |
| Coordinates | 551176..551637 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | RL00_RS03140 | Protein ID | WP_001260485.1 |
| Coordinates | 551650..551973 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RL00_RS03115 | 548163..549368 | - | 1206 | WP_000264191.1 | site-specific integrase | - |
| RL00_RS03120 | 549478..550101 | + | 624 | WP_001166482.1 | hypothetical protein | - |
| RL00_RS03125 | 550300..550695 | - | 396 | WP_000449653.1 | hypothetical protein | - |
| RL00_RS03130 | 550724..551158 | - | 435 | WP_000755718.1 | hypothetical protein | - |
| RL00_RS03135 | 551176..551637 | - | 462 | WP_000525002.1 | hypothetical protein | Toxin |
| RL00_RS03140 | 551650..551973 | - | 324 | WP_001260485.1 | helix-turn-helix domain-containing protein | Antitoxin |
| RL00_RS03145 | 552137..552385 | + | 249 | WP_000272860.1 | helix-turn-helix domain-containing protein | - |
| RL00_RS03150 | 552401..552646 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| RL00_RS03155 | 552615..552980 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| RL00_RS03160 | 553035..553250 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| RL00_RS03165 | 553275..553538 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| RL00_RS03170 | 553551..553712 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| RL00_RS03175 | 553791..554114 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| RL00_RS03180 | 554129..554491 | + | 363 | WP_000985979.1 | hypothetical protein | - |
| RL00_RS03185 | 554488..555654 | + | 1167 | WP_000762552.1 | DUF2800 domain-containing protein | - |
| RL00_RS03190 | 555680..556237 | + | 558 | WP_000645048.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | lukS-PV / lukF-PV | 545174..593712 | 48538 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 17943.33 Da Isoelectric Point: 5.0698
>T93145 WP_000525002.1 NZ_CP026073:c551637-551176 [Staphylococcus aureus]
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T93145 NZ_CP026073:c551637-551176 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT93145 WP_001260485.1 NZ_CP026073:c551973-551650 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT93145 NZ_CP026073:c551973-551650 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|