MGE detailed information
MGE type: Integrative_Conjugative_Elements MGE length: 97481 bp
Accession: NC_013316 Location: 2043677..2141157 Organism: Clostridium difficile R20291 Replicon: chromosome
Accession: NC_013316 Location: 2043677..2141157 Organism: Clostridium difficile R20291 Replicon: chromosome
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CDR20291_RS09480 | 2039167..2040417 | + | 1251 | Protein_1814 | DUF11 domain-containing protein | - |
| CDR20291_RS09490 (CDR20291_1741) | 2040727..2041008 | + | 282 | WP_009891898.1 | hypothetical protein | - |
| CDR20291_RS09495 (CDR20291_1742) | 2041094..2042116 | + | 1023 | WP_009891897.1 | hypothetical protein | - |
| CDR20291_RS09500 | 2042118..2042603 | + | 486 | WP_009891896.1 | PcfB family protein | - |
| CDR20291_RS09505 | 2042600..2043604 | + | 1005 | WP_104732836.1 | type IV secretory system conjugative DNA transfer family protein | - |
| CDR20291_RS09510 (CDR20291_1744) | 2043677..2045557 | + | 1881 | WP_012816185.1 | hypothetical protein ; Integrase | Integrase |
| CDR20291_RS09515 (CDR20291_1745) | 2045584..2045937 | + | 354 | WP_012816186.1 | TnpV protein | - |
| CDR20291_RS09520 (CDR20291_1746) | 2045954..2046253 | + | 300 | WP_004612693.1 | hypothetical protein | - |
| CDR20291_RS09525 (CDR20291_1747) | 2046281..2046649 | - | 369 | WP_012816188.1 | helix-turn-helix transcriptional regulator | - |
| CDR20291_RS09530 | 2046794..2046982 | + | 189 | WP_007884040.1 | helix-turn-helix domain-containing protein | - |
| CDR20291_RS09535 (CDR20291_1748) | 2046975..2047667 | + | 693 | WP_024738629.1 | Transcriptional regulatory protein WalR | VF |
| CDR20291_RS09540 (CDR20291_1749) | 2047673..2048590 | + | 918 | WP_012816190.1 | HAMP domain-containing histidine kinase | - |
| CDR20291_RS09545 (CDR20291_1750) | 2048725..2049651 | + | 927 | WP_104732837.1 | Bacitracin transport ATP-binding protein BcrA | VF |
| CDR20291_RS09550 (CDR20291_1751) | 2049644..2050429 | + | 786 | WP_012816192.1 | ABC transporter permease | - |
| CDR20291_RS09555 (CDR20291_1752) | 2050432..2051211 | + | 780 | WP_002594767.1 | ABC transporter permease | - |
| CDR20291_RS09560 (CDR20291_1753) | 2051219..2051680 | + | 462 | WP_012816193.1 | hypothetical protein | - |
| CDR20291_RS09565 (CDR20291_1754) | 2052125..2052538 | + | 414 | WP_012816194.1 | hypothetical protein | - |
| CDR20291_RS09570 (CDR20291_1755) | 2052640..2053092 | + | 453 | WP_012816195.1 | sigma-24 (feci) | - |
| CDR20291_RS09575 (CDR20291_1756) | 2053103..2053564 | + | 462 | WP_009296689.1 | sigma-70 family RNA polymerase sigma factor | - |
| CDR20291_RS09580 (CDR20291_1757) | 2053593..2053883 | + | 291 | WP_024739841.1 | DUF3847 domain-containing protein | - |
| CDR20291_RS09585 (CDR20291_1758) | 2054070..2055515 | + | 1446 | WP_104732839.1 | MobA/MobL family protein | - |
| CDR20291_RS09590 (CDR20291_1759) | 2055623..2055913 | - | 291 | WP_002596328.1 | type II toxin-antitoxin system YafQ family toxin | Toxin Detail |
| CDR20291_RS09595 (CDR20291_1760) | 2055910..2056188 | - | 279 | WP_005924829.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin Detail |
| CDR20291_RS09600 (CDR20291_1761) | 2056315..2056713 | + | 399 | WP_012816198.1 | cysteine-rich VLP domain-containing protein | - |
| CDR20291_RS09605 (CDR20291_1762) | 2056827..2057561 | + | 735 | WP_012816199.1 | phage replisome organizer N-terminal domain-containing protein | - |
| CDR20291_RS09610 (CDR20291_1763) | 2057558..2058421 | + | 864 | WP_104732840.1 | IS21 family transposase ISBlo1 | Transposase |
| CDR20291_RS09615 | 2058465..2058659 | + | 195 | WP_104732841.1 | transposon-encoded TnpW family protein | - |
| CDR20291_RS09620 (CDR20291_1764) | 2058737..2059102 | + | 366 | WP_104732842.1 | hypothetical protein | - |
| CDR20291_RS09625 | 2059197..2059823 | + | 627 | Protein_1842 | TraM recognition domain-containing protein | - |
| CDR20291_RS09630 (CDR20291_1765) | 2059876..2060253 | + | 378 | WP_009891894.1 | TnpV protein | - |
| CDR20291_RS09635 | 2060267..2060548 | + | 282 | WP_009891893.1 | hypothetical protein | - |
| CDR20291_RS09640 (CDR20291_1766) | 2060670..2061518 | - | 849 | WP_009891891.1 | helix-turn-helix domain-containing protein | - |
| CDR20291_RS09645 | 2061884..2062177 | + | 294 | WP_021407349.1 | hypothetical protein | - |
| CDR20291_RS09650 | 2062161..2062466 | + | 306 | WP_074014306.1 | molecular chaperone | - |
| CDR20291_RS09655 (CDR20291_1768) | 2062894..2064138 | + | 1245 | WP_021422885.1 | hypothetical protein | - |
| CDR20291_RS09660 (CDR20291_1769) | 2064154..2064840 | + | 687 | WP_074014307.1 | DNA primase | - |
| CDR20291_RS09665 (CDR20291_1770) | 2064800..2066158 | + | 1359 | WP_009891879.1 | virulence-associated E family protein | - |
| CDR20291_RS09670 | 2066426..2066593 | + | 168 | WP_009891878.1 | hypothetical protein | - |
| CDR20291_RS09675 (CDR20291_1771) | 2066666..2068318 | + | 1653 | WP_012816204.1 | hypothetical protein ; Integrase | Integrase |
| CDR20291_RS09680 | 2068366..2068821 | - | 456 | WP_009901261.1 | hypothetical protein | - |
| CDR20291_RS09685 (CDR20291_1772) | 2068845..2070518 | - | 1674 | WP_009893984.1 | hypothetical protein ; Integrase | Integrase |
| CDR20291_RS09690 | 2070596..2070769 | - | 174 | WP_002604472.1 | transposon-encoded TnpW family protein | - |
| CDR20291_RS09695 | 2071228..2071470 | - | 243 | WP_002604473.1 | helix-turn-helix domain-containing protein | - |
| CDR20291_RS09700 (CDR20291_1773) | 2071454..2071891 | - | 438 | WP_002604474.1 | sigma-70 family RNA polymerase sigma factor | - |
| CDR20291_RS09705 (CDR20291_1774) | 2072365..2073348 | - | 984 | WP_002584956.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| CDR20291_RS09710 | 2073365..2073550 | - | 186 | WP_003431289.1 | hypothetical protein | - |
| CDR20291_RS09715 | 2074161..2074322 | + | 162 | Protein_1860 | helix-turn-helix transcriptional regulator | - |
| CDR20291_RS09720 (CDR20291_1775) | 2074593..2075303 | - | 711 | WP_009891854.1 | LytTR family DNA-binding domain-containing protein | - |
| CDR20291_RS09725 | 2075308..2075481 | - | 174 | WP_002576203.1 | helix-turn-helix domain-containing protein | - |
| CDR20291_RS09730 | 2075623..2075856 | + | 234 | Protein_1863 | conjugal transfer protein TraG | - |
| CDR20291_RS09735 (CDR20291_1776) | 2076020..2076331 | + | 312 | WP_009891846.1 | single-stranded DNA-binding protein | - |
| CDR20291_RS09740 | 2076335..2076493 | + | 159 | WP_042520385.1 | conjugal transfer protein | - |
| CDR20291_RS09745 | 2076649..2076921 | + | 273 | WP_009274451.1 | helix-turn-helix domain-containing protein | - |
| CDR20291_RS09750 (CDR20291_1777) | 2076881..2077258 | + | 378 | WP_009274452.1 | TnpV protein | - |
| CDR20291_RS09755 (CDR20291_1778) | 2077375..2077809 | + | 435 | WP_009274453.1 | MarR family transcriptional regulator | - |
| CDR20291_RS09760 (CDR20291_1779) | 2077802..2079103 | + | 1302 | WP_012816206.1 | multidrug transporter MatE | - |
| CDR20291_RS09765 (CDR20291_1780) | 2079197..2080003 | - | 807 | WP_012816207.1 | helix-turn-helix domain-containing protein | - |
| CDR20291_RS09770 | 2080487..2080675 | + | 189 | WP_055058411.1 | hypothetical protein | - |
| CDR20291_RS09775 (CDR20291_1781) | 2080672..2081013 | + | 342 | WP_003020305.1 | DeoR family transcriptional regulator | - |
| CDR20291_RS09780 (CDR20291_1782) | 2081006..2081302 | + | 297 | WP_012816208.1 | DUF3847 domain-containing protein | - |
| CDR20291_RS09785 | 2081602..2081745 | + | 144 | WP_009274458.1 | hypothetical protein | - |
| CDR20291_RS09790 (CDR20291_1784) | 2081933..2083513 | + | 1581 | WP_042520383.1 | MobA/MobL family protein | - |
| CDR20291_RS09795 (CDR20291_1785) | 2083579..2084223 | + | 645 | WP_042520382.1 | hypothetical protein | - |
| CDR20291_RS09800 (CDR20291_1786) | 2084192..2085529 | + | 1338 | WP_042520381.1 | virulence-associated E family protein | - |
| CDR20291_RS09805 | 2085771..2085968 | + | 198 | WP_004612761.1 | hypothetical protein | - |
| CDR20291_RS09810 (CDR20291_1788) | 2085969..2087639 | + | 1671 | WP_012816213.1 | hypothetical protein ; Integrase | Integrase |
| CDR20291_RS09815 | 2087730..2087813 | + | 84 | Protein_1880 | hypothetical protein | - |
| CDR20291_RS09820 (CDR20291_1789) | 2087833..2088696 | + | 864 | WP_009893980.1 | hypothetical protein | - |
| CDR20291_RS09825 | 2088714..2088974 | + | 261 | WP_009888259.1 | hypothetical protein | - |
| CDR20291_RS09830 | 2088978..2089367 | + | 390 | WP_009888260.1 | PrgI family protein | - |
| CDR20291_RS09835 (CDR20291_1790) | 2089279..2091708 | + | 2430 | WP_009888261.1 | ATP-binding protein | - |
| CDR20291_RS09840 (CDR20291_1791) | 2091712..2093844 | + | 2133 | WP_009888262.1 | CHAP domain-containing protein | - |
| CDR20291_RS09845 | 2093856..2094095 | + | 240 | WP_009888263.1 | hypothetical protein | - |
| CDR20291_RS09850 (CDR20291_1792) | 2094070..2095611 | + | 1542 | WP_009893977.1 | DUF4366 domain-containing protein | - |
| CDR20291_RS09855 (CDR20291_1793) | 2095706..2097412 | + | 1707 | WP_009893975.1 | DNA topoisomerase 3 | - |
| CDR20291_RS09860 (CDR20291_1794) | 2097497..2098300 | + | 804 | WP_004804477.1 | KilA-N domain-containing protein | - |
| CDR20291_RS09865 (CDR20291_1795) | 2098383..2107112 | + | 8730 | WP_009893973.1 | DEAD/DEAH box helicase family protein | - |
| CDR20291_RS09870 (CDR20291_1796) | 2107155..2107814 | + | 660 | WP_010826392.1 | hypothetical protein | - |
| CDR20291_RS09875 | 2107954..2108184 | + | 231 | WP_009889816.1 | helix-turn-helix transcriptional regulator | - |
| CDR20291_RS09880 (CDR20291_1797) | 2108387..2110009 | + | 1623 | WP_009889819.1 | AAA family ATPase | - |
| CDR20291_RS09885 (CDR20291_1798) | 2110006..2111073 | + | 1068 | WP_009889821.1 | UvrD-helicase domain-containing protein | - |
| CDR20291_RS09890 | 2111101..2111562 | + | 462 | WP_009889823.1 | hypothetical protein | - |
| CDR20291_RS09895 (CDR20291_1799) | 2111552..2112358 | + | 807 | WP_009889825.1 | PQQ-like beta-propeller repeat protein | - |
| CDR20291_RS09900 (CDR20291_1800) | 2112394..2113725 | - | 1332 | WP_009889829.1 | relaxase/mobilization nuclease domain-containing protein | - |
| CDR20291_RS09905 | 2113731..2114081 | - | 351 | WP_009889831.1 | plasmid mobilization relaxosome protein MobC | - |
| CDR20291_RS09910 (CDR20291_1801) | 2114415..2115572 | + | 1158 | WP_009893966.1 | TlpA family protein disulfide reductase | - |
| CDR20291_RS19075 | 2115651..2115746 | + | 96 | WP_196783929.1 | thioredoxin | - |
| CDR20291_RS09915 (CDR20291_1802) | 2115739..2116629 | + | 891 | WP_009889834.1 | 4Fe-4S binding protein | - |
| CDR20291_RS09920 (CDR20291_1803) | 2116648..2117925 | + | 1278 | WP_009889836.1 | ABC transporter permease | - |
| CDR20291_RS09925 (CDR20291_1804) | 2117935..2118591 | + | 657 | WP_003426165.1 | putative ABC transporter ATP-binding protein | VF |
| CDR20291_RS09930 (CDR20291_1805) | 2118591..2119967 | + | 1377 | WP_009893965.1 | ABC transporter permease | - |
| CDR20291_RS09935 (CDR20291_1806) | 2120065..2120718 | + | 654 | WP_009889840.1 | Transcriptional regulatory protein QseB | VF |
| CDR20291_RS09940 (CDR20291_1807) | 2120715..2122034 | + | 1320 | WP_009889841.1 | HAMP domain-containing histidine kinase | - |
| CDR20291_RS09945 (CDR20291_1808) | 2122558..2122968 | + | 411 | WP_003426191.1 | sigma-70 family RNA polymerase sigma factor | - |
| CDR20291_RS09950 | 2123457..2123609 | + | 153 | WP_003426199.1 | hypothetical protein | - |
| CDR20291_RS09955 (CDR20291_1809) | 2123710..2125359 | + | 1650 | Protein_1909 | Tn3 family transposase TnpR_ISAcsp1 | Transposase |
| CDR20291_RS09960 (CDR20291_1739) | 2125384..2128632 | + | 3249 | Protein_1910 | Tn3 family transposase TnpR_ISAcsp1 | Transposase |
| CDR20291_RS09965 (CDR20291_1810) | 2129089..2129436 | + | 348 | WP_003435528.1 | cupin domain-containing protein | - |
| CDR20291_RS09970 (CDR20291_1811) | 2129586..2130635 | - | 1050 | WP_003423932.1 | ABC transporter substrate-binding protein | - |
| CDR20291_RS09975 (CDR20291_1812) | 2131021..2131755 | + | 735 | WP_009889846.1 | class I SAM-dependent methyltransferase | - |
| CDR20291_RS09980 (CDR20291_1813) | 2131897..2132388 | - | 492 | WP_003428667.1 | prolyl-tRNA synthetase associated domain-containing protein | - |
| CDR20291_RS09985 (CDR20291_1814) | 2132737..2133120 | + | 384 | WP_009889847.1 | hypothetical protein | - |
| CDR20291_RS09990 (CDR20291_1815) | 2133626..2134009 | + | 384 | WP_003428669.1 | YtxH domain-containing protein | - |
| CDR20291_RS09995 (CDR20291_1816) | 2134011..2134361 | + | 351 | WP_003428670.1 | hypothetical protein | - |
| CDR20291_RS10000 (CDR20291_1817) | 2134455..2134913 | - | 459 | WP_003435468.1 | hypothetical protein | - |
| CDR20291_RS10005 (CDR20291_1818) | 2134958..2135746 | - | 789 | WP_003435466.1 | N-acetylmuramoyl-L-alanine amidase | - |
| CDR20291_RS10010 (CDR20291_1819) | 2135885..2136322 | - | 438 | WP_009889849.1 | dCMP deaminase | - |
| CDR20291_RS10015 (CDR20291_1821) | 2137144..2137653 | + | 510 | WP_009889853.1 | hypothetical protein | VF |
| CDR20291_RS10020 (CDR20291_1824) | 2138564..2139364 | - | 801 | WP_003435446.1 | ABC transporter permease | - |
| CDR20291_RS10025 (CDR20291_1826) | 2139559..2141157 | - | 1599 | WP_009893325.1 | Tn3 family transposase TnpR_TnShfr1 | Transposase |
| CDR20291_RS10030 (CDR20291_1827) | 2141485..2141661 | + | 177 | WP_009889863.1 | hypothetical protein | - |
| CDR20291_RS10035 (CDR20291_1828) | 2141835..2142965 | + | 1131 | WP_009893327.1 | iron-containing alcohol dehydrogenase | - |
| CDR20291_RS10040 (CDR20291_1829) | 2143206..2143556 | + | 351 | WP_009893329.1 | BMC domain-containing protein | - |
| CDR20291_RS10045 (CDR20291_1830) | 2143564..2144013 | + | 450 | WP_009889866.1 | EutP/PduV family microcompartment system protein | - |
| CDR20291_RS10050 (CDR20291_1831) | 2144115..2144690 | + | 576 | WP_003423977.1 | response regulator | - |
| CDR20291_RS10055 (CDR20291_1832) | 2144683..2146092 | + | 1410 | WP_009889869.1 | histidine kinase N-terminal domain-containing protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|---|---|---|---|---|---|
| Clostridioides difficile strain CD-17-01474 | Integrative and Conjugative Element | TA95210 | NZ_CP026591 | 2053693..2151173 | 0 | |
| Clostridioides difficile R20291 | Integrative and Conjugative Element | TA105647 | NZ_CP029423 | 2057242..2154722 | 0 | |
| Clostridioides difficile strain R_phiCD75-3 | Integrative and Conjugative Element | TA260525 | NZ_CP107108 | 2085392..2182872 | 0 | |
| Clostridioides difficile strain R_cdtRmut6.1 | Integrative and Conjugative Element | TA260529 | NZ_CP107109 | 2057259..2154739 | 0 | |
| Clostridioides difficile strain R_cdtRstop8 | Integrative and Conjugative Element | TA260533 | NZ_CP107110 | 2057275..2154755 | 0 | |
| Clostridioides difficile strain R_cdtRstop4.2 | Integrative and Conjugative Element | TA260537 | NZ_CP107111 | 2057110..2154590 | 0 | |
| Clostridioides difficile strain R_cdtRKO8.1 | Integrative and Conjugative Element | TA260541 | NZ_CP107112 | 2057269..2154749 | 0 | |
| Clostridioides difficile strain R_cdtRKO10.3 | Integrative and Conjugative Element | TA260545 | NZ_CP107113 | 2057288..2154768 | 0 | |
| Clostridioides difficile R20291 | Integrative and Conjugative Element | TA267075 | NZ_CP115183 | 2057275..2154755 | 0 |