Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
Location | 2069215..2069780 | Replicon | chromosome |
Accession | NZ_CP107112 | ||
Organism | Clostridioides difficile strain R_cdtRKO8.1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | C7H6P5 |
Locus tag | OGM25_RS09760 | Protein ID | WP_002596328.1 |
Coordinates | 2069215..2069505 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | C7H6P4 |
Locus tag | OGM25_RS09765 | Protein ID | WP_005924829.1 |
Coordinates | 2069502..2069780 (-) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OGM25_RS09730 (OGM25_09730) | 2064811..2065272 | + | 462 | WP_012816193.1 | hypothetical protein | - |
OGM25_RS09735 (OGM25_09735) | 2065717..2066130 | + | 414 | WP_012816194.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
OGM25_RS09740 (OGM25_09740) | 2066232..2066684 | + | 453 | WP_012816195.1 | sigma-24 (feci) | - |
OGM25_RS09745 (OGM25_09745) | 2066695..2067156 | + | 462 | WP_009296689.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
OGM25_RS09750 (OGM25_09750) | 2067185..2067475 | + | 291 | WP_024739841.1 | DUF3847 domain-containing protein | - |
OGM25_RS09755 (OGM25_09755) | 2067662..2069107 | + | 1446 | WP_104732839.1 | MobQ family relaxase | - |
OGM25_RS09760 (OGM25_09760) | 2069215..2069505 | - | 291 | WP_002596328.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
OGM25_RS09765 (OGM25_09765) | 2069502..2069780 | - | 279 | WP_005924829.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
OGM25_RS09770 (OGM25_09770) | 2069907..2070305 | + | 399 | WP_012816198.1 | cysteine-rich VLP domain-containing protein | - |
OGM25_RS09775 (OGM25_09775) | 2070419..2071153 | + | 735 | WP_012816199.1 | phage replisome organizer N-terminal domain-containing protein | - |
OGM25_RS09780 (OGM25_09780) | 2071150..2072013 | + | 864 | WP_104732840.1 | ATP-binding protein | - |
OGM25_RS09785 (OGM25_09785) | 2072057..2072251 | + | 195 | WP_104732841.1 | transposon-encoded TnpW family protein | - |
OGM25_RS09790 (OGM25_09790) | 2072329..2072694 | + | 366 | WP_104732842.1 | hypothetical protein | - |
OGM25_RS09795 (OGM25_09795) | 2072789..2073370 | + | 582 | Protein_1846 | TraM recognition domain-containing protein | - |
OGM25_RS09800 (OGM25_09800) | 2073468..2073845 | + | 378 | WP_009891894.1 | TnpV protein | - |
OGM25_RS09805 (OGM25_09805) | 2073859..2074140 | + | 282 | WP_009891893.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integrative and Conjugative Element | - | - | 2057269..2154749 | 97480 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11112.87 Da Isoelectric Point: 8.0630
>T260541 WP_002596328.1 NZ_CP107112:c2069505-2069215 [Clostridioides difficile]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
Download Length: 291 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1M4XBM1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1M4XB19 |