Detailed information of component protein


Summary

Component ID T6CP011413
Component protein type PAAR
T6SS ID (Type) T6SS00023 experimental (Type i3)
Strain Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Replicon chromosome
Sequence Protein sequence (1365 a.a.); Nucleotide sequence (4095 bp)
Reference
[1] Blondel CJ, Jiménez JC, Contreras I, et al. Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 2009 Aug 4;10:354. doi: 10.1186/1471-2164-10-354. PMID: 19653904
[2] Boyer F, Fichant G, Berthod J, et al. Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? BMC Genomics. 2009 Mar 12;10:104. doi: 10.1186/1471-2164-10-104. PMID: 19284603
[3] Benz J, Reinstein J, Meinhart A. Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium. PLoS One. 2013 Jun 27;8(6):e67362. doi: 10.1371/journal.pone.0067362. Print 2013. PMID: 23826277
[4] Sana TG, Flaugnatti N, Lugo KA, et al. Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5044-51. doi: 10.1073/pnas.1608858113. Epub 2016 Aug 8. PMID: 27503894
experimental Experimental investigation has been performed on this T6SS
External database links

Locus tag (Gene) STM0291
Coordinate (Strand) 332552..336646 (+)
NCBI ID NP_459289.1
RefSeq NC_003197
Uniprot ID Q8ZRL0_SALTY
KEGG ID stm:STM0291
PDB ID -
Pfam domain hit(s)

Domain Pfam ID E-value Aligned region
DUF6531 PF20148.1 1.7e-21 224..296
PAAR_motif PF05488.15 3.9e-14 72..138
RHS_repeat PF05593.16 1.4e-10 582..619
RHS PF03527.16 2.1e-09 1146..1177
RHS_repeat PF05593.16 3.1e-07 624..660
RHS_repeat PF05593.16 5.2e-07 518..555
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Inside 1-16 MYEAARVDDPIYHTSA
Transmembrane helix 17-39 LAGFLIGAIIGIAIIALAAFAFF
Outside 40-1364 SCGFLAGLILGFMADQIASGVLQLGEAIGRSIHHTAGKILTGSENVSTNSRPAARAVLSTVKCDNHIAEKRIAQGSENIYINSQPAARKDDHTECDAVIEDGSPNVFLGGGTQTVLEISSEIPDWLRKVVDVLFVVASLLGGLAGAWRQAAKLGTKFGTKCAAKFIGGELVGMAVGEAISGLFSNPVDVTTGQKILLPETDFTLPGRLPVTCSRFYASHLETVGLLGRGWRLNWETSLRDDDEHITLTGVQGRELRYPKTMLTPGHQIFDPEEQLYLSRLHDGRYVLHYTDRSYYVFGDFDSDGMAYLLFMETPHRQRIVFGHEGGRLVRIASSSGHHLLLHRTQTPAGERLSRIELVQGGTRGNLVEYRYDDNGQLTGVVNRAGTQVRQFAYENGLMTAHSNATGFTCRYRWQELDGAPRVTEHDTSDGEHYRFDYDFAAGTTTVTGRQGETWQWWYDRETYITAHRTPGGGMYRFTYNEDHFPVNIELPGGRTVAYEYDIQNRVVKTTDPEGRVTQTQWNGEFDEITRTALDDDAVWKTQYNAHGQPVQETDPEGRVTQYAYDEQGQMCSRTDAAGGTVVTAFDSRGQMTRYTDCSGRSTGYDHDEDGNLTRVTDAEGKVVRISYNRLGLPETVNSPGKQQDRYTWNALGLMSSHRRITGSVESWRYTPRGLLAAHTDEEKRETRWQYTPEGRVAALTNGNGAQYRFSHDADGRLVREVRPDGLSRTFILDDSGYLTAIQTTGTQGGVRRETQQRDALGRLLRTENEHGQRTFSYNRLDQITAVTLTPTEAGQQQHRMQADTVRFEYDRSGWLTAEHAGNGSICYQRDALGNPTDITLPDGQHLTHLYYGSGHLLQTALDGLTVSEYERDSLHRQIMRTQGQLATYSGYDDDGLLSWQRSLASGSAPVLPGQRPARQGCVTSRDYYWNNHGEVGTIDDGLRGSVVYSYDRSGYLTGRSGQMYDHDRYYYDKAGNLLDNEGQGAVMSNRLPGCGRDRYGYNEWGELTTRRDQQLEWNAQGQLTRVISGNTETHYGYDALGRRTRKATYGRHTGHTARSRTDFVWEGFRLLQENVQQQGWRTYLYDAEQPYTPVASVTGRGESRQVWYYHTDVTGTPQEVTAADGTLVWAGYIRGFGENAADISNSGAYFHQPLRLPGQYFDDETGLHYNLFRYYAPECGRFVSQDPIGLRGGLNLYQYAPNPLKYIDPLGLTATVGRWMGPAEYQQMLDTGTVVQSSTGTTHVAYPADIDAFGKQAKNGAMYVEFDVPEKSLVPTNEGWAKIVGPDSIEGRLAKRKGLPVPEMPTAENITVRGEKINGEVEAKC


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9955 - -


  Protein sequence: 1365 a.a.    

>T6CP011413 NC_003197:332552-336646 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] [PAAR]
MYEAARVDDPIYHTSALAGFLIGAIIGIAIIALAAFAFFSCGFLAGLILGFMADQIASGVLQLGEAIGRSIHHTAGKILT
GSENVSTNSRPAARAVLSTVKCDNHIAEKRIAQGSENIYINSQPAARKDDHTECDAVIEDGSPNVFLGGGTQTVLEISSE
IPDWLRKVVDVLFVVASLLGGLAGAWRQAAKLGTKFGTKCAAKFIGGELVGMAVGEAISGLFSNPVDVTTGQKILLPETD
FTLPGRLPVTCSRFYASHLETVGLLGRGWRLNWETSLRDDDEHITLTGVQGRELRYPKTMLTPGHQIFDPEEQLYLSRLH
DGRYVLHYTDRSYYVFGDFDSDGMAYLLFMETPHRQRIVFGHEGGRLVRIASSSGHHLLLHRTQTPAGERLSRIELVQGG
TRGNLVEYRYDDNGQLTGVVNRAGTQVRQFAYENGLMTAHSNATGFTCRYRWQELDGAPRVTEHDTSDGEHYRFDYDFAA
GTTTVTGRQGETWQWWYDRETYITAHRTPGGGMYRFTYNEDHFPVNIELPGGRTVAYEYDIQNRVVKTTDPEGRVTQTQW
NGEFDEITRTALDDDAVWKTQYNAHGQPVQETDPEGRVTQYAYDEQGQMCSRTDAAGGTVVTAFDSRGQMTRYTDCSGRS
TGYDHDEDGNLTRVTDAEGKVVRISYNRLGLPETVNSPGKQQDRYTWNALGLMSSHRRITGSVESWRYTPRGLLAAHTDE
EKRETRWQYTPEGRVAALTNGNGAQYRFSHDADGRLVREVRPDGLSRTFILDDSGYLTAIQTTGTQGGVRRETQQRDALG
RLLRTENEHGQRTFSYNRLDQITAVTLTPTEAGQQQHRMQADTVRFEYDRSGWLTAEHAGNGSICYQRDALGNPTDITLP
DGQHLTHLYYGSGHLLQTALDGLTVSEYERDSLHRQIMRTQGQLATYSGYDDDGLLSWQRSLASGSAPVLPGQRPARQGC
VTSRDYYWNNHGEVGTIDDGLRGSVVYSYDRSGYLTGRSGQMYDHDRYYYDKAGNLLDNEGQGAVMSNRLPGCGRDRYGY
NEWGELTTRRDQQLEWNAQGQLTRVISGNTETHYGYDALGRRTRKATYGRHTGHTARSRTDFVWEGFRLLQENVQQQGWR
TYLYDAEQPYTPVASVTGRGESRQVWYYHTDVTGTPQEVTAADGTLVWAGYIRGFGENAADISNSGAYFHQPLRLPGQYF
DDETGLHYNLFRYYAPECGRFVSQDPIGLRGGLNLYQYAPNPLKYIDPLGLTATVGRWMGPAEYQQMLDTGTVVQSSTGT
THVAYPADIDAFGKQAKNGAMYVEFDVPEKSLVPTNEGWAKIVGPDSIEGRLAKRKGLPVPEMPTAENITVRGEKINGEV
EAKC*

  Nucleotide sequence: 4095 bp    

>T6CP011413 NC_003197:332552-336646 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] [PAAR]
ATGTATGAAGCAGCCCGTGTGGATGATCCTATCTACCACACCAGCGCGCTCGCCGGGTTTCTTATCGGCGCTATCATCGG
CATCGCCATTATCGCGCTTGCCGCCTTTGCCTTCTTTAGCTGCGGTTTTCTTGCCGGGCTGATTCTGGGTTTTATGGCCG
ATCAAATAGCCTCCGGGGTATTGCAACTGGGCGAGGCCATCGGGCGCTCCATCCACCACACGGCAGGAAAAATCCTCACC
GGTTCGGAGAATGTCAGCACCAACAGTCGCCCGGCGGCGCGCGCGGTACTGAGTACGGTGAAATGCGATAACCATATCGC
AGAAAAACGCATCGCCCAAGGGTCGGAAAATATCTACATCAACAGCCAGCCCGCCGCCCGTAAGGATGACCACACCGAAT
GCGACGCGGTGATTGAAGACGGTTCGCCGAATGTGTTTCTCGGCGGCGGCACACAGACGGTACTGGAAATCAGTTCTGAA
ATTCCGGACTGGCTGCGCAAGGTGGTGGATGTATTGTTTGTCGTGGCGAGTCTGCTCGGCGGGCTGGCCGGGGCGTGGCG
GCAGGCGGCAAAGCTGGGGACGAAATTTGGCACTAAATGTGCCGCTAAGTTTATCGGCGGGGAGCTTGTCGGGATGGCCG
TGGGTGAGGCTATCAGCGGGCTGTTCAGCAATCCGGTGGATGTGACCACCGGGCAGAAAATCCTGCTGCCGGAAACGGAC
TTCACCCTGCCCGGTCGCCTGCCGGTCACCTGCTCGCGTTTTTACGCCAGCCACCTGGAAACTGTGGGACTGTTGGGACG
GGGCTGGCGGCTGAACTGGGAAACCAGCCTGCGCGATGACGATGAACACATCACGCTGACCGGCGTACAGGGGCGGGAAC
TGCGTTACCCGAAAACGATGCTGACGCCCGGCCACCAGATATTTGACCCGGAAGAACAGTTATACCTCAGCCGCCTGCAT
GACGGGCGTTACGTGCTGCATTACACCGATCGCAGCTATTACGTATTTGGTGATTTTGACAGTGACGGCATGGCATACCT
GCTGTTTATGGAGACGCCGCACCGCCAGCGCATTGTCTTCGGGCACGAAGGAGGCAGACTGGTACGGATAGCCTCCAGCA
GCGGGCATCACCTGTTACTGCACCGCACACAGACCCCGGCAGGGGAGCGGCTGTCGCGAATTGAACTGGTGCAGGGCGGC
ACCCGTGGCAATCTGGTGGAGTACCGGTATGACGATAACGGTCAACTGACCGGCGTGGTGAACCGGGCGGGAACGCAGGT
GCGTCAGTTTGCTTATGAAAACGGGCTGATGACGGCGCACAGCAATGCGACGGGGTTCACCTGCCGCTACCGCTGGCAGG
AACTCGACGGCGCGCCGCGCGTGACGGAGCACGACACCAGTGACGGCGAACATTACCGCTTTGACTATGATTTTGCCGCA
GGCACCACCACCGTCACCGGCAGGCAGGGGGAGACATGGCAGTGGTGGTACGACAGGGAAACGTATATCACCGCGCACCG
GACGCCGGGCGGTGGAATGTACCGCTTCACGTACAACGAAGACCACTTCCCTGTCAACATTGAGCTGCCCGGCGGTCGCA
CGGTGGCGTATGAATATGACATCCAGAACCGGGTGGTGAAGACGACAGATCCGGAAGGCCGGGTGACGCAGACGCAGTGG
AACGGCGAGTTCGACGAAATCACGCGCACGGCGCTGGACGATGACGCTGTCTGGAAAACGCAGTACAACGCCCACGGCCA
GCCAGTGCAGGAGACGGACCCGGAAGGGCGGGTGACGCAGTACGCTTACGATGAACAGGGGCAGATGTGCAGCCGGACGG
ATGCGGCGGGCGGCACGGTGGTGACGGCGTTCGACAGCCGGGGGCAGATGACGCGGTACACCGACTGTTCAGGGCGCAGC
ACAGGATATGACCACGATGAGGACGGCAACCTGACGCGGGTGACGGACGCGGAAGGGAAGGTGGTACGCATCAGCTACAA
CCGACTTGGGTTGCCGGAGACGGTAAACTCACCGGGGAAACAGCAGGACAGGTATACCTGGAATGCGCTGGGGCTGATGA
GCAGCCACCGGCGCATCACGGGGAGCGTGGAGAGCTGGCGGTATACGCCGCGCGGTCTGCTGGCGGCGCACACGGATGAG
GAGAAGCGCGAGACGCGCTGGCAGTACACGCCGGAAGGCCGGGTGGCAGCGCTGACCAACGGCAACGGGGCGCAGTACCG
GTTCAGTCACGATGCGGACGGCAGGCTGGTGCGTGAGGTTCGCCCGGACGGACTGAGCCGTACTTTTATCCTGGACGACA
GCGGTTATCTGACGGCGATACAGACCACGGGCACGCAGGGCGGCGTGCGGCGGGAGACGCAGCAGCGGGATGCGCTGGGC
CGTCTGTTACGGACGGAGAATGAACACGGCCAGCGGACGTTCAGCTACAACCGGCTGGACCAGATAACGGCAGTGACGCT
CACGCCCACGGAGGCGGGGCAACAGCAGCACCGGATGCAGGCCGACACGGTGCGTTTTGAGTATGACCGCAGCGGCTGGC
TGACGGCGGAGCACGCGGGGAACGGTAGCATATGTTATCAGCGCGACGCGCTGGGCAACCCGACGGACATCACGCTGCCG
GACGGGCAGCACCTGACGCATCTGTATTACGGGAGCGGGCATCTGTTACAGACGGCGCTGGACGGCCTGACGGTGAGCGA
GTATGAGCGCGACAGCCTGCACCGTCAGATAATGCGCACGCAGGGGCAGCTTGCGACGTACAGCGGCTATGACGACGACG
GGCTGCTGAGCTGGCAGCGCAGTCTGGCGTCCGGCAGTGCCCCTGTTCTTCCTGGCCAGCGCCCGGCGCGGCAGGGCTGC
GTGACGTCGAGGGACTATTACTGGAACAACCACGGCGAGGTGGGCACGATTGACGACGGCCTGCGTGGCAGCGTGGTGTA
CAGCTATGACAGAAGCGGTTACCTGACCGGGCGCTCAGGTCAGATGTATGACCATGACCGTTATTATTACGATAAGGCGG
GCAACCTGCTGGATAACGAAGGGCAGGGAGCGGTGATGAGCAACCGGCTGCCGGGCTGTGGTCGTGACCGTTACGGCTAT
AACGAGTGGGGCGAGCTGACCACGCGGCGCGACCAGCAACTGGAGTGGAACGCGCAGGGGCAGCTGACGCGGGTCATCAG
CGGCAACACGGAGACGCACTACGGCTACGATGCGCTGGGGAGGCGAACCCGCAAGGCGACGTACGGGCGGCACACGGGCC
ATACGGCGCGGAGCCGGACGGACTTTGTGTGGGAGGGGTTCAGGCTGTTGCAGGAGAACGTGCAGCAGCAGGGCTGGCGG
ACCTATCTGTACGATGCGGAACAGCCGTACACGCCGGTGGCGAGCGTGACGGGGCGGGGAGAAAGCAGGCAGGTGTGGTA
TTACCACACGGATGTGACGGGCACGCCGCAGGAGGTGACGGCGGCGGACGGAACGCTGGTGTGGGCGGGGTATATCAGGG
GGTTTGGAGAGAATGCGGCGGACATCAGCAACAGCGGGGCGTACTTTCACCAGCCGCTGCGGCTGCCGGGGCAGTATTTT
GACGACGAGACAGGGCTGCATTACAATCTGTTCAGATATTATGCACCGGAGTGTGGACGGTTTGTCAGTCAGGATCCGAT
CGGGCTGAGGGGCGGGTTAAACCTTTATCAGTATGCGCCAAATCCTCTCAAATATATAGACCCACTTGGTTTAACCGCGA
CTGTTGGGCGATGGATGGGGCCTGCGGAATATCAGCAAATGCTTGATACTGGGACAGTAGTACAAAGTTCAACAGGGACA
ACTCATGTTGCCTACCCTGCTGATATAGATGCTTTTGGTAAGCAAGCAAAAAATGGTGCTATGTATGTTGAATTTGATGT
GCCTGAAAAATCATTAGTACCTACAAATGAAGGATGGGCAAAAATAGTAGGGCCAGATTCTATCGAAGGGCGATTAGCTA
AACGCAAAGGTTTGCCTGTTCCTGAAATGCCAACAGCAGAAAACATAACTGTAAGGGGCGAGAAAATTAATGGGGAAGTT
GAAGCAAAATGCTAA