Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   EL070_RS01110 Genome accession   NZ_LR134284
Coordinates   192047..193408 (+) Length   453 a.a.
NCBI ID   WP_111705438.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8232     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 187047..198408
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL070_RS10130 (NCTC8232_00215) comD/blpH 187801..188190 (+) 390 WP_231873482.1 GHKL domain-containing protein Regulator
  EL070_RS09995 (NCTC8232_00216) - 188261..188404 (-) 144 WP_023612234.1 hypothetical protein -
  EL070_RS10315 - 189178..189309 (+) 132 WP_023612236.1 hypothetical protein -
  EL070_RS01105 (NCTC8232_00218) comA 189888..192038 (+) 2151 WP_023612228.1 peptide cleavage/export ABC transporter ComA Regulator
  EL070_RS01110 (NCTC8232_00219) comB 192047..193408 (+) 1362 WP_111705438.1 bacteriocin secretion accessory protein Regulator
  EL070_RS01115 (NCTC8232_00220) - 193550..193723 (+) 174 WP_023612227.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  EL070_RS01120 (NCTC8232_00221) - 193742..193909 (+) 168 WP_023612226.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  EL070_RS01130 (NCTC8232_00223) - 194546..195895 (+) 1350 WP_011184137.1 glucose-6-phosphate isomerase -
  EL070_RS01135 - 196244..197752 (-) 1509 WP_023610487.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 50748.50 Da        Isoelectric Point: 7.3015

>NTDB_id=999997 EL070_RS01110 WP_111705438.1 192047..193408(+) (comB) [Streptococcus pyogenes strain NCTC8232]
MYEELLESSEFYQKRYHNFSSRIILPILGLLIFLVIFLTFMKKEVTIKSQATVEPVKVLAQIQSISNNTIKINNLQENKL
VNKYDLLVEYEISNEIIQHDSTQDQLNILKQQKEQLELLKSSIQSGSSKFPEADAFGYYKRFEDYIGQRQTITSNVKQQN
GTIASQNTASKNTQNTIGGLINDTSQKIANYEAAKSAIQSGRVVDATNPAYSIYSTYVSQSLALVKEVEKTTLMNQVVAQ
LDSQIQQYKTALSNYQIQYSGAGVQQAYNSSLDSQLDSLQSQKIAEISQELTALDQKVKELNGGFLLQQNTLKETELRAS
VAGIVHVNPEVIDSSIIPKGTIIAQIFPKLEDAKEARIETYISSRDITSLKIGDTVKFKTQDSSNKEVTLQSKITSIDSS
ATKTKEGSYFKVIAKVKLSSKQLEDLKYGSSGDLVVITGEKTYLKYYIDKFLN

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=999997 EL070_RS01110 WP_111705438.1 192047..193408(+) (comB) [Streptococcus pyogenes strain NCTC8232]
ATGTACGAAGAACTATTAGAAAGCTCGGAATTTTATCAGAAACGTTATCATAATTTTTCAAGTAGAATTATTTTACCAAT
ACTTGGTTTATTGATTTTTTTGGTTATCTTTTTAACGTTTATGAAAAAGGAAGTCACGATAAAAAGCCAAGCAACAGTTG
AGCCAGTAAAAGTATTAGCTCAAATTCAATCAATTAGTAATAATACAATTAAAATAAATAATCTTCAAGAAAATAAATTA
GTCAATAAATATGATTTACTTGTTGAATATGAGATATCTAATGAGATAATTCAACATGATAGTACTCAAGATCAGTTAAA
TATTCTTAAACAACAAAAAGAACAATTGGAATTATTGAAATCTAGTATTCAGAGTGGAAGTAGCAAATTTCCTGAAGCAG
ATGCCTTTGGTTACTACAAGCGATTTGAAGATTATATCGGCCAACGTCAAACGATTACTAGTAATGTAAAACAACAAAAT
GGAACCATAGCATCTCAAAATACAGCATCAAAAAACACTCAAAATACAATTGGAGGTCTGATCAATGATACCTCTCAAAA
AATAGCAAATTATGAAGCAGCTAAAAGTGCAATTCAAAGTGGCCGAGTAGTAGATGCTACTAATCCAGCTTATTCTATTT
ATTCAACTTATGTGAGTCAAAGTTTAGCATTGGTTAAAGAAGTTGAAAAAACAACGTTAATGAATCAGGTAGTTGCTCAA
CTTGATTCTCAAATACAACAATATAAAACAGCATTATCAAATTATCAGATTCAGTATTCTGGAGCAGGAGTACAGCAAGC
TTATAATTCAAGTTTAGATAGTCAACTTGATTCATTACAATCGCAAAAAATAGCAGAGATAAGTCAGGAATTAACGGCTT
TAGATCAAAAAGTTAAGGAATTGAATGGTGGCTTCTTATTGCAACAAAATACTTTAAAAGAGACTGAACTTAGAGCTAGT
GTAGCAGGAATTGTTCATGTCAATCCTGAAGTGATTGATTCATCTATTATTCCTAAAGGGACAATTATTGCACAAATCTT
CCCGAAGTTAGAAGATGCGAAAGAAGCCAGAATTGAGACCTACATATCTTCTAGAGACATAACGAGCTTGAAAATTGGTG
ATACAGTTAAATTCAAGACCCAGGATTCTTCAAATAAAGAAGTTACCTTGCAATCTAAGATAACCAGTATTGACAGTAGT
GCAACTAAGACAAAAGAGGGGAGTTATTTTAAAGTTATTGCCAAAGTAAAATTATCAAGTAAACAGTTAGAAGATTTGAA
ATATGGTTCATCAGGAGATTTAGTTGTGATAACCGGAGAGAAAACTTACCTAAAATATTATATTGATAAATTTTTAAATT
AG

Domains

Predicted by InterProScan.

HlyD family secretion protein ()

(317-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae R6

47.903

100

0.479
  comB Streptococcus pneumoniae Rx1

47.903

100

0.479
  comB Streptococcus pneumoniae D39

47.903

100

0.479
  comB Streptococcus mitis SK321

47.682

100

0.477
  comB Streptococcus pneumoniae TIGR4

47.682

100

0.477
  comB Streptococcus gordonii str. Challis substr. CH1

47.02

100

0.47
  comB Streptococcus mitis NCTC 12261

46.799

100

0.468