Detailed information NTG0999203

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: ABD410_RS04675
• Genome accession: NZ_CP155740
• Coordinates: 911759..912595 (+)
• Length: 278 a.a.
• NCBI ID: WP_023611998.1
• Uniprot ID: A0A5S4TFX7
• Organism: Streptococcus pyogenes strain 1851/03
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 906759..917595

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD410_RS04645 (ABD410_04620)	-	907313..907681 (+)	369	WP_010922310.1	hypothetical protein	-
ABD410_RS04650 (ABD410_04625)	-	907731..908642 (-)	912	WP_023612012.1	diacylglycerol kinase family protein	-
ABD410_RS04655 (ABD410_04630)	-	908759..909409 (-)	651	WP_002984629.1	hemolysin III family protein	-
ABD410_RS04660 (ABD410_04635)	-	909406..909846 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
ABD410_RS04665 (ABD410_04640)	ylqF	910065..910913 (+)	849	WP_023611994.1	ribosome biogenesis GTPase YlqF	-
ABD410_RS04670 (ABD410_04645)	-	910903..911694 (+)	792	WP_023612045.1	ribonuclease HII	-
ABD410_RS04675 (ABD410_04650)	dprA	911759..912595 (+)	837	WP_023611998.1	DNA-processing protein DprA	Machinery gene
ABD410_RS04680 (ABD410_04655)	topA	912703..914832 (+)	2130	WP_050336211.1	type I DNA topoisomerase	-
ABD410_RS04685 (ABD410_04660)	-	914907..915791 (-)	885	Protein_875	LysR family transcriptional regulator	-
ABD410_RS04690 (ABD410_04665)	-	915804..916370 (+)	567	Protein_876	PTS sugar transporter subunit IIC	-
ABD410_RS04695 (ABD410_04670)	-	916385..917377 (+)	993	WP_023612447.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30958.92 Da
• Isoelectric Point: 8.8230

>NTDB_id=999203 ABD410_RS04675 WP_023611998.1 911759..912595(+) (dprA) [Streptococcus pyogenes strain 1851/03]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGAACVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=999203 ABD410_RS04675 WP_023611998.1 911759..912595(+) (dprA) [Streptococcus pyogenes strain 1851/03]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAGCATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A5S4TFX7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis SK321	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.432	100	0.604
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367