Detailed information NTG0999027

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: ABD412_RS04675
• Genome accession: NZ_CP155737
• Coordinates: 911451..912287 (+)
• Length: 278 a.a.
• NCBI ID: WP_023611998.1
• Uniprot ID: A0A5S4TFX7
• Organism: Streptococcus pyogenes strain 9606/11
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 906451..917287

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD412_RS04645 (ABD412_04620)	-	907005..907373 (+)	369	WP_010922310.1	hypothetical protein	-
ABD412_RS04650 (ABD412_04625)	-	907423..908334 (-)	912	WP_023612012.1	diacylglycerol kinase family protein	-
ABD412_RS04655 (ABD412_04630)	-	908451..909101 (-)	651	WP_002984629.1	hemolysin III family protein	-
ABD412_RS04660 (ABD412_04635)	-	909098..909538 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
ABD412_RS04665 (ABD412_04640)	ylqF	909757..910605 (+)	849	WP_023611994.1	ribosome biogenesis GTPase YlqF	-
ABD412_RS04670 (ABD412_04645)	-	910595..911386 (+)	792	WP_023612045.1	ribonuclease HII	-
ABD412_RS04675 (ABD412_04650)	dprA	911451..912287 (+)	837	WP_023611998.1	DNA-processing protein DprA	Machinery gene
ABD412_RS04680 (ABD412_04655)	topA	912395..914524 (+)	2130	WP_050336211.1	type I DNA topoisomerase	-
ABD412_RS04685 (ABD412_04660)	-	914599..915483 (-)	885	Protein_875	LysR family transcriptional regulator	-
ABD412_RS04690 (ABD412_04665)	-	915496..916062 (+)	567	Protein_876	PTS sugar transporter subunit IIC	-
ABD412_RS04695 (ABD412_04670)	-	916077..917069 (+)	993	WP_023612447.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30958.92 Da
• Isoelectric Point: 8.8230

>NTDB_id=999027 ABD412_RS04675 WP_023611998.1 911451..912287(+) (dprA) [Streptococcus pyogenes strain 9606/11]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGAACVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=999027 ABD412_RS04675 WP_023611998.1 911451..912287(+) (dprA) [Streptococcus pyogenes strain 9606/11]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAGCATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A5S4TFX7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis SK321	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.432	100	0.604
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367